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Journal of Chinese Integrative Medicine ›› 2006, Vol. 4 ›› Issue (1): 272-275.doi: 10.3736/jcim20070309

• Original Clinical Research • Previous Articles    

Effect of intravenous drip infusion of cyclophosphamide with high-dose Astragalus injection in treating lupus nephritis

Su Li, Jan-chun Mao, Jun-hua Gu   

  1. Department of Rheumatology , Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200030 ,China
  • Online:2006-01-20 Published:2006-01-15

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Objective

To observe the effect of high-dose Astragalus injection and cyclophosphamide (CTX) on infection, urine protein and immune function of the patients with lupus nephritis.

Methods

Forty-three patients diagnosed as systemic lupus erythematosus (SLE) complicated by kidney damage and qi-deficiency syndrome were randomly divided into trial group (n=23) and control group (n=20). Patients in both groups were treated for 3 months. Intravenous drip infusion of 0.8 g CTX was administered to all patients once a month, while intravenous drip infusion of 20 ml Astragalus injection was only administered to patients in the trial group every day for 12 days in each month.

Results

The decrease of active clinical symptom score after the treatment in the trial group was greater than that in the control group (P<0.05). The infection rates of the trial group and the control group were 4.35% and 25% respectively. The decrease of 24-hour urine protein and CD8, and the increase of red blood cell count and serum albumin in the trial group were greater than those in the control group, and there were significant differences between the two groups (P<0.05). White blood cell count in the trial group was decreased less than that in the control group after the treatment (P<0.05).

Conclusion

High-dose Astragalus injection used together with CTX is more effective than CTX alone in decreasing infection rate and urine protein and improving immune function for patients with lupus nephritis.

Key words: Lupus erythematosus,systemic, Lupus nephritis, Cyclophosphamide, Astragalus membranaceus, Intravenous drip

CLC Number: 

  • R593.242

Table 1

Comparison of active clinical symptom score between two groups （ヌ±S）"

Group n Active clinical symptom score
Control
Pre-treatment 20 3.87±1.51
Post-treatment 20 2.19±1.13*
Trial
Pre-treatment 23 3.61±1.25
Post-treatment 23 1.59±0.84**△

Table 2

Comparisons of 24 hour urine protein, total serum protein, and serum albumin between two groups （ヌ±S）"

Group n 24 hours urine protein (g/24 h) Serum albumin (g/L) Total serum protein (g/L)
Control
Pre-treatment 20 3.26±1.86 30.12±6.79 58.96±13.43
Post-treatment 20 1.96±0.98** 29.97±7.21 57.28±15.33
Trial
Pre-treatment 23 3.14±1.91 27.27±8.63 57.91±15.46
Post-treatment 23 1.07±0.60 **△ 34.75±5.70*△ 61.51±11.36

Table 3

Comparisons of blood cell count and ESR between two groups （ヌ±S）"

Group n Red blood cell ( ×1012/L) White blood cell ( ×109/L) Blood platelet ( ×109/L) ESR (mm/h)
Control
Pre-treatment 20 3.17±0.42 5.31±0.49 149.83±47.78 77.97±22.87
Post-treatment 20 3.09±0.37 3.91±0.82* 146.12±61.27 40.77±21.61**
Trial
Pre-treatment 23 3.19±0.58 5.27±0.55 152.61±58.12 81.45±25.65
Post-treatment 23 3.69±0.43*△ 4.83±1.18△ 153.45±37.21 36.63±19.78**

Table 4

Comparison of T-cell subsets between two groups （ヌ±S）"

Group n CD3 CD4 CD8
Control
Pre-treatment 20 73.79±18.38 36.42±11.35 39.17±14.31
Post-treatment 20 66.27±13.59 39.25±13.41 41.23±16.20
Trial
Pre-treatment 23 72.19±20.56 33.78±10.81 40.15±11.88
Post-treatment 23 68.95±18.67 37.69±11.23 33.73±12.11*△
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