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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (5): 468-472.doi: 10.3736/jcim20080507

• Original Clinical Research • Previous Articles     Next Articles

Effects of Astragalous Injection on oxidative stress status in maintenance hemodialysis patients

Xiao-lu Qu1(), Qin Dai1, Ying-hui Qi1, Yong-hua Tang1, Da-hua Xu1, Zhong-hua Wu2, Xiao-xia Wang1   

  1. 1. Department of Nephrology, Shanghai Punan Hospital of Pudong New District, Shanghai 200125, China
    2. Center of Technology and Experiment, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • Received:2008-03-14 Online:2008-05-20 Published:2008-05-15
  • Contact: QU Xiao-lu

Objective: To analyze the effects of Astragalous Injection on oxidative stress and micro-inflammatory status in patients undergoing maintenance hemodialysis (MHD).
Methods: Sixty MHD patients were included and randomized into treatment group and control group, with another 10 healthy volunteers as normal control. The patients in the treatment group were treated with Astragalous Injection and the patients in the control group were treated with normal saline for 12 weeks. A spectrophotometric method was used for the measurement of plasma concentrations of oxidative parameters including advanced glycation end products (AGEs), advanced oxidation protein product (AOPP), malondialdehyde (MDA) and vitamin E (Vit E). The content of C-reactive protein (CRP) was evaluated by enzyme-linked immunosorbent assay.
Results: Compared with the normal control group, the plasma levels of AGEs, AOPP, MDA and CRP were significantly increased, while plasma level of Vit E was significantly decreased in MHD patients (P<0.01). After Astragalous Injection treatment, the plasma levels of AGEs, AOPP, MDA and CRP were decreased as compared with the control group (P<0.01), while there was no significant difference in plasma Vit E level between the treatment group and control group.
Conclusion: There exist oxidative stress and micro-inflammation in MHD patients. Astragalous Injection can ameliorate the accumulation of oxidative products and micro-inflammatory status, but it has no significant effect on plasma Vit E level.

Key words: Astragalous membranaceus , hemodialysis, oxidative stress

CLC Number: 

  • R459.52

Table 1

General data in different groups"

General data Normal control (n=10) Control (n=30) Treatment (n=30)
Sex (male/female) 6/4 18/12 12/18
Age ($\bar{x}$±s, years) 43.60±11.41 54.40±12.57 53.03±12.04
Time of therapy ($\bar{x}$±s, months) 31.17±25.59 27.23±15.80
Systolic blood pressure ($\bar{x}$±s, mmHg) 121.78±13.59 148.28±12.24 144.36±15.47
Diastolic blood pressure ($\bar{x}$±s, mmHg) 65.32±23.94 84.25±9.30 84.75±10.55
Hemoglobin ($\bar{x}$±s, g/L) 117.58±21.09 95.00±24.47 90.39±18.56
Primary disease
Chronic glomerulonephritis 0 7 10
Hypertension 0 12 6
Diabetic nephropathy 0 3 6
Urate nephropathy 0 1 1
Polycystic kidney disease 0 1 1
Lupus nephritis 0 0 1
Medical damage 0 0 1
Chronic interstitial nephritis 0 0 1
Chronic pyelonephritis 0 1 0
End-stage renal disease 0 5 3

Table 2

Changes of oxidation indexes in different group (?x ± s )"

Group n AGEs (U) AOPP (nmol/L) MDA (nmol/L) CRP (mg/L) Vit E (mg/L)
Normal control 10 1.30±0.27 67.09±25.90 3.30±1.37 2.25±1.27 13.02±3.92
Pre-treatment 30 3.31±1.44** 120.76±54.59** 5.41±1.15** 7.96±6.93* 6.93±2.97**
Post-treatment 30 3.91±0.81 136.27±95.44 5.02±1.13 6.64±6.83 6.50±1.46
Pre-treatment 28 3.42±2.26** 125.35±53.51** 5.78±1.58** 6.72±6.82* 7.02±2.42**
Post-treatment 28 2.68±0.86△△▲ 87.67±41.48△▲ 4.31±1.41▲▲ 3.88±3.04 7.27±2.10
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