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Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (6): 621-624.doi: 10.3736/jcim20070604

Special Issue: Traditional Chinese Medicine

• Original Clinical Research • Previous Articles     Next Articles

Relationship between syndrome differentiation of traditional Chinese medicine and vascular endothelial function in patients with diabetic arterial occlusion of lower extremities

Lian-qing Sun1,2, Yan Yang3, Wei Zheng4   

  1. 1. Department of Peripheral Vascular Diseases,Affiliated Hospital,Shandong University of Traditional Chinese Medicine,Ji-nan,Shandong Province 250011,China
    2. Department of Traditional Chinese Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Scences,Beijing 100730,China
    3. Department of Pharmacy,Shandong Provincial Hospital,Jinan,Shandong Province 250021,China
    4. Department of Healthcare,Affiliated Hospital,Shandong University of Traditional Chinese Medicine,Jinan,Province 250011,China Shandong
  • Online:2007-11-20 Published:2007-11-15

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：Objective: To investigate the relationship between syndrome differentiation of traditional Chinese medicine (TCM) and characteristic changes of vascular endothelial function in patients with diabetic arterial occlusion (DAO) of lower extremities.Methods: Forty patients with DAO were selected as trial group. Twenty patients among them were attributed to blood stasis syndrome (group A1), and the others were attributed to syndrome of pathogenic dampness-heat attacking the lower limb (group A2) according to syndrome differentiation type of TCM. Patients with diabetes (group B), arteriosclerosis obliterans (group C) and healthy people (group D) were observed as the control groups, respectively. There were 20 cases in each group. Endothelium-dependent dilation (EDD) and endothelium-independent dilation (EID) were measured by high resolution ultrasound in the 100 subjects and the changes of vascular tension factors were also studied. Results: The results showed that EDD in group A was reduced significantly as compared with that in the groups B, C and D. The levels of vascular contractile factors such as endothelin-1 (ET-1) and thromboxane B2 (TXB2) in group A were higher than those in the groups B, C and D, while the levels of vascular dilatory factors such as nitric oxide (NO) and 6-keto-prostaglandin F1α (6-Keto-PGF1α) were declined significantly as compared with those in the groups B and D. Linear correlation analysis showed that EDD was correlated positively with the levels of NO and 6-Keto-PGF1α, while the levels of ET-1 and TXB2 had negative correlation with EDD. EDD and EID in group A2 were declined significantly as compared with those in group A1.Conclusion: Our findings indicate that endothelial dysfunction may play an important role in the pathogenesis of DAO and may be associated with syndrome differentiation of TCM.

Key words: diabetic angiopathies, blood vessels, endothelium, syndrome differentiation, ultrasonography

CLC Number: 

  • R587.25

Table 1

Levels of blood pressure, blood glucose, triglyceride and total cholesterol in different groups (?x±s)"

Group n Age (year) SBP (mmHg) DBP (mmHg) TC (mmol/L) TG (mmol/L) FBG (mmol/L)
A1 20 66.80±9.96 148.31±12.72** 95.12±6.49** 5.31±0.92* 1.44±0.53 8.86±3.26**△△
A2 20 67.05±8.34 154.14±9.63** 96.73±7.21** 5.58±1.23* 1.53±0.67 8.67±4.32**△△
B 20 65.10±9.47 143.53±11.41** 91.38±8.63** 5.29±0.87* 1.37±0.71 11.63±3.79**△△
C 20 65.32±8.77 151.67±10.88** 93.27±5.84** 5.41±1.02* 1.42±0.63 5.05±1.26
D 20 64.10±8.96 122.04±11.37 74.89±5.28 4.72±0.76 1.36±0.56 4.67±0.76

Table 2

Changes of vasodilation function (?x±s )"

Group Diameter (mm) EDD (%) EID (%)
A1 4.04±0.39 6.22±1.27**△ △▲▲ 12.85±1.19
A2 4.02±0.41 4.02±2.35**△△▲▲ □□ 9.07±6.36**△ △ ▲▲ □□
B 3.95±0.42 9.01±1.12* 14.56±2.34
C 3.99±0.40 8.42±1.73** 14.94±1.95
D 4.01±0.35 10.58±2.92 15.17±2.71

Table 3

Changes of vascular tension factors"

Group NO (μmol/L) TXB2 (ng/L) k-Keto-PGF1α (ng/L) ET-1 (ng/L)
A1 63.54±9.45**▲ 97.54±10.93** ▲▲ 63.21±5.76** ▲▲ 74.10±11.49**▲
A2 57.17±8.45**△△▲▲□□ 106.19±14.46* * △▲▲□□ 59.52±7.72* *▲▲ 88.27±14.79** △▲▲ □□
B 69.98±6.16*△ 88.26±9.28** △△ 70.04±6.27**△ 66.25±10.01**△△
C 62.91±10.63* * 95.66±11.79** 64.33±8.14** 77.86±14.31* *
D 74.91±6.69 76.71±9.11 77.24±6.27 53.93±8.34
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