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Journal of Chinese Integrative Medicine ›› 2012, Vol. 10 ›› Issue (11): 1206-1210.doi: 10.3736/jcim20121103

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Thinking on building the network cardiovasology of Chinese medicine

Gui Yu1, Jie Wang1,2()   

  1. 1. Department of Cardiology, Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053, China;
    2. Hubei University of Chinese Medicine,Wuhan 430065,Hubei Province,China
  • Received:2012-03-15 Accepted:2012-03-29 Online:2012-11-20 Published:2018-11-15

With advances in complex network theory, the thinking and methods regarding complex systems have changed revolutionarily. Network biology and network pharmacology were built by applying network-based approaches in biomedical research. The cardiovascular system may be regarded as a complex network, and cardiovascular diseases may be taken as the damage of structure and function of the cardiovascular network. Although Chinese medicine (CM) is effective in treating cardiovascular diseases, its mechanisms are still unclear. With the guidance of complex network theory, network biology and network pharmacology, network-based approaches could be used in the study of CM in preventing and treating cardiovascular diseases. A new discipline — network cardiovasology of CM was, therefore, developed. In this paper, complex network theory, network biology and network pharmacology were introduced and the connotation of “disease-syndrome-formula-herb” was illustrated from the network angle. Network biology could be used to analyze cardiovascular diseases and syndromes and network pharmacology could be used to analyze CM formulas and herbs. The “network-network”-based approaches could provide a new view for elucidating the mechanisms of CM treatment.

Key words: complex network, cardiovascular diseases, Chinese medicine, network cardiovasology

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