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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (7): 700-703.doi: 10.3736/jcim200800708

• Original Clinical Research • Previous Articles     Next Articles

Dishen Qufeng Decoction for treating allergic rhinitis: a randomized controlled trial

Wei-rong Zhu1, Shou-jie Zhang1, De-hou Zheng2, Xiao-heng Shen1()   

  1. 1. Department of Traditional Chinese Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiao tong University, Shanghai 200025, China
    2. Postgraduate School, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China
  • Received:2007-12-05 Online:2008-07-20 Published:2008-07-15
  • Contact: SHEN Xiao-heng E-mail:meilixling@163.com

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Objective: To observe the clinical therapeutic effects of Dishen Qufeng Decoction (DSQFD), a compound traditional Chinese herbal medicine, in treatment of allergic rhinitis.
Methods: Sixty cases of allergic rhinitis were selected and randomized into DSQFD group (30 cases) and cetirizine group (30 cases), and the patients were orally administered DSQFD and cetirizine respectively. The integrals of patients' symptoms, such as sneezing, nose running, nasal occlusion and nasal itching, signs in the nasal conchae and peripheral blood eosinophil (EOS) count were abserved count before and after treatment.
Results: DSQFD obviously improved the symptoms and signs of allergic rhinitis. The total response rate of DSQFD treatment was 83.3%, while that of the cetirizine treatment was 86.7%; the EOS counts in both groups were significantly decreased. These results showed statistical difference between the two groups.
Conclusion: DSQFD is an effective preparation of traditional Chinese medicine for treating allergic rhinitis.

Key words: Dishen Qufeng Decoction, allergic rhinitis, randomized controlled trials, clinical research

CLC Number: 

  • R765.213

Figure 1

Standard of symptom score for allergic rhinitis"

Grading score Sneezing (continuous number) Nose running (number/d) Nasal occlusion Nasal itching
1分 3~9 ≤4 Happened by chance Happened by chance
2分 10~14 5~9 Happened by chance or mouth breath Formication, and can endure
3分 ≥15 ≥10 Mouth breath Formication, and can not endure

Table 2

Total sign and symptom score in different groups ($\bar{x}$±s)"

Group n Total sign and symptom score Difference value t
After treatment Before treatment
Cetirizine 30 10.35±1.19 5.79±1.55** 4.54±1.43 12.55
DSQFD 30 9.79±1.17 5.93±1.94** 3.86±1.35 9.01

Table 3

Symptom and sign score in different groups ($\bar{x}$±s)"

Group n Symptom and sign score
Sneezing Nose running Nasal occlusion Nasal itching Physical signs
Cetirizine
Before treatment 30 2.11±0.50 2.32±0.61 2.00±0.27 1.92±0.46 1.96±0.51
After treatment 30 1.00±0.38** 1.54±0.58** 1.14±0.44** 1.21±0.57** 0.89±0.79**
DSQFD
Before treatment 30 1.93±0.60 2.25±0.52 1.93±0.47 1.82±0.39 1.86±0.45
After treatment 30 1.04±0.74** 1.46±0.64** 1.54±0.58** 0.86±0.53** 1.04±0.64**

Table 4

Eosinophile granulocyte count in different groups ($\bar{x}$±s, ×109/L)"

Group n Eosinophile granulocyte count
Before treatment After treatment t
Cetirizine 30 0.39±0.38 0.21±0.20* 2.29
DSQFD 30 0.41±0.34 0.24±0.21* 2.40
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