地参祛风合剂治疗变应性鼻炎的随机对照临床研究

doi:10.3736/jcim200800708

Abstract

Objective: To observe the clinical therapeutic effects of Dishen Qufeng Decoction (DSQFD), a compound traditional Chinese herbal medicine, in treatment of allergic rhinitis.
Methods: Sixty cases of allergic rhinitis were selected and randomized into DSQFD group (30 cases) and cetirizine group (30 cases), and the patients were orally administered DSQFD and cetirizine respectively. The integrals of patients' symptoms, such as sneezing, nose running, nasal occlusion and nasal itching, signs in the nasal conchae and peripheral blood eosinophil (EOS) count were abserved count before and after treatment.
Results: DSQFD obviously improved the symptoms and signs of allergic rhinitis. The total response rate of DSQFD treatment was 83.3%, while that of the cetirizine treatment was 86.7%; the EOS counts in both groups were significantly decreased. These results showed statistical difference between the two groups.
Conclusion: DSQFD is an effective preparation of traditional Chinese medicine for treating allergic rhinitis.

Key words: Dishen Qufeng Decoction, allergic rhinitis, randomized controlled trials, clinical research

CLC Number:

R765.213

Wei-rong Zhu, Shou-jie Zhang, De-hou Zheng, Xiao-heng Shen. Dishen Qufeng Decoction for treating allergic rhinitis: a randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(7): 700-703.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim200800708

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References 8

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Grading score	Sneezing (continuous number)	Nose running (number/d)	Nasal occlusion	Nasal itching
1分	3~9	≤4	Happened by chance	Happened by chance
2分	10~14	5~9	Happened by chance or mouth breath	Formication, and can endure
3分	≥15	≥10	Mouth breath	Formication, and can not endure

Group	n	Total sign and symptom score		Difference value	t
Group	n	After treatment	Before treatment	Difference value	t
Cetirizine	30	10.35±1.19	5.79±1.55**	4.54±1.43	12.55
DSQFD	30	9.79±1.17	5.93±1.94**	3.86±1.35	9.01

Group	n	Symptom and sign score
Group	n	Sneezing	Nose running	Nasal occlusion	Nasal itching	Physical signs
Cetirizine
Before treatment	30	2.11±0.50	2.32±0.61	2.00±0.27	1.92±0.46	1.96±0.51
After treatment	30	1.00±0.38**	1.54±0.58**	1.14±0.44**	1.21±0.57**	0.89±0.79**
DSQFD
Before treatment	30	1.93±0.60	2.25±0.52	1.93±0.47	1.82±0.39	1.86±0.45
After treatment	30	1.04±0.74**	1.46±0.64**	1.54±0.58**	0.86±0.53**	1.04±0.64**

Group	n	Eosinophile granulocyte count
Group	n	Before treatment	After treatment	t
Cetirizine	30	0.39±0.38	0.21±0.20*	2.29
DSQFD	30	0.41±0.34	0.24±0.21*	2.40

Dishen Qufeng Decoction for treating allergic rhinitis: a randomized controlled trial

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