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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (8): 856-859.doi: 10.3736/jcim20080816

• Original Experimental Research • Previous Articles     Next Articles

Effects of different Chinese herbal medicines on biochemical parameters in guinea-pig with pigment gallstones

Jing-zhe Zhang1(), Xue-lin Zhang1, Xiao-qiang Liang2, Hong-gang Gu1, Pei-ting Zhu1   

  1. 1. Department of Hepatobiliary Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
    2. Institute of Chinese Traditional Surgery, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
  • Received:2008-02-14 Online:2008-08-20 Published:2008-08-15

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Objective: To observe the effects of Qingdan Capsule (QDC) and Yanggan Lidan Granule (YGLDG), two kinds of compound traditional Chinese herbal medicines, on biochemical parameters in guinea-pigs with pigment gallstones.
Methods: An animal model of pigment gallstones was established in male guinea-pigs by hypodermic injection of lincomycin. The guinea-pigs were randomly divided into blank control group, untreated group, QDC group and YGLDG group. There were 8 guinea-pigs in each group. After ten-day treatment, animals were sacrificed and sampled to calculate the rate of stone formation, total bilirubin (TB), unconjugated bilirubin (UCB) and Ca2+ density in bile of the four groups.
Results: In comparison with the untreated group, the rates of stone formation in the QDC and YGLDG groups were significantly decreased (P<0.01). TBIL, UCB and Ca2+ content of bile in both QDC and YGLD groups was also significantly decreased (P<0.05, P<0.01).
Conclusion: QDC and YGLD have good effects on biochemical changes of animal model of pigment gallstone in reversing the lithogenesity of bile by reducing the content of TB, UCB and Ca2+, hence resulting in clinical treatment and prevention of pigment gallstone disease.

Key words: choleretics, bile pigments, cholelithiasis, guinea-pigs

CLC Number: 

  • R575.623

Table 1

Levels of total bilirubin, unconjugated bilirubin and Ca2 in four groups (x±s)"

Group n Total bilirubin (μmol/L) Unconjugated bilirubin (μmol/L) Ca2+ (mmol/L)
Blank control 8 7.43±5.36** 2.43±5.44** 0.60±0.40**
Untreated 8 34.59±4.29 22.62±3.61 1.30±0.19
Qingdan Capsule 8 29.62±6.12 15.61±6.26* 0.51±0.29**
Yanggan Lidan Granule 8 22.60±4.42* 9.94±4.24* 0.61±0.19**
[1] Biliary Groups of Surgery, Surgery Academy of China . The trend of the gallstone disease in China over the past decade[J]. Zhonghua Wai Ke Za Zhi, 1995,33(11):652-658
中华外科学会胆道外科学组. 我国胆石病十年来的变迁[J]. 中华外科杂志, 1995,33(11):652-658
[2] Guan ZZ, Tang QL . Research progress of formation factors of bile pigment calculus[J].Heze Yi Xue Zhuan Ke Xue Xiao Xue Bao, 2007,19(1):68-73
doi: 10.3969/j.issn.1008-4118.2007.01.046
关中正, 唐乾利 . 胆色素结石形成的因素研究进展[J]. 菏泽医学专科学校学报, 2007,19(1):68-73
doi: 10.3969/j.issn.1008-4118.2007.01.046
[3] Zhu PT, Zhang JZ, Cao ZP , et al. Summary of 274 cases of infection of biliary tract and cholelithiasis[J]. Shanghai Zhong Yi Yao Za Zhi, 1986,20(9):15-17
朱培庭, 张静喆, 曹中平 , 等. 治疗慢性胆道感染、胆石病274例的总结[J]. 上海中医药杂志, 1986,20(9):15-17
[4] Xu CS, Zhu PT, Cao ZP , et al. Experimental study of animal model and drug prevention and cure of bile pigment stones[J]. Zhonghua Xiao Hua Za Zhi, 1982,2(1):34-36
徐长生, 朱培庭, 曹中平 , 等. 胆色素结石动物模型及药物防治的实验研究[J]. 中华消化杂志, 1982,2(1):34-36
[5] Wang JT, Chen YQ, Niu SK . Effect of free radicle in the formation of bile pigment stones[J]. Shanxi Yi Yao Za Zhi, 1999,28(2):116-118
王俊田, 陈允清, 牛树凯 . 自由基对豚鼠胆色素结石形成的影响[J]. 山西医药杂志, 1999,28(2):116-118
[6] Chen Q. The experimental methods of traditional Chinese medicinal pharmacology[M]. Beijing: People's Medical Publishing House,1994: 206-231
陈奇 . 中药药理实验方法学[M]. 北京: 人民卫生出版社,1994: 206-231
[7] Zhang XB, Cui NQ, Li DH . Effect of clearing heat and removing dampness method on formation of pigment gallstones in rabbits[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2007,27(3):241-243
doi: 10.3321/j.issn:1003-5370.2007.03.014
张西波, 崔乃强, 李东华 . 清热利湿方防治兔胆色素结石形成的实验研究[J]. 中国中西医结合杂志, 2007,27(3):241-243
doi: 10.3321/j.issn:1003-5370.2007.03.014
[8] Pundir CS, Rani K, Garg P , et al. Correlation between chemical composition of biliary calculi and sera of stone formers[J]. Indian J Med Sci, 2002,56(8):373-375
pmid: 12645161
[9] Hou JY. Pharmacology of Chinese herbs[M]. Beijing: Traditional Chinese Medical Publisher,2002: 120-231
侯家玉 . 中药药理学[M]. 北京: 中国中医药出版社,2002: 120-231
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