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Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (3): 238-243.doi: 10.3736/jcim20100307

• Original Clinical Research • Previous Articles     Next Articles

Analysis of relationships among syndrome, therapeutic treatment, and Chinese herbal medicine in patients with coronary artery disease based on complex networks

 Zhu-ye Gaoa, Jing-chun Zhanga, Hao Xub, Da-zhuo Shia, Chang-geng Fua, Dan Qub, Xue-zhong Zhouc   

  1. a Department of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
    b National Integrative Medicine Center of Cardiovascular Diseases, China-Japan Friendship Hospital, Beijing 100029, China
    c College of Computer and Information Technology, Beijing Jiaotong University, Beijing 100044, China
  • Received:2009-11-05 Accepted:2010-02-05 Online:2010-03-20 Published:2010-03-15
  • Contact: Jing-chun Zhang,Hao Xu E-mail:zhangjingchun276@vip.sohu.com.;xuhao2005@sohu.com

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Objective

To analyze the relationships among syndrome, therapeutic method and Chinese herbal medicine in patients with coronary artery disease (CAD).
Methods

Using cross-sectional survey, we collected the clinical information of hospitalized CAD patients through individualized Information Acquisition Platform of CAD. The relationships among syndrome, therapeutic treatment and Chinese herbs were excavated by means of complex networks based on theory of correspondence between prescription and syndrome.
Results

The fundamental syndrome factors were blood stasis, qi deficiency, phlegm-turbid, yin deficiency, yang deficiency, qi stagnation, and blood deficiency. The therapeutic treatment mainly included activating blood circulation, clearing heat, invigorating qi, resolving turbid and phlegm, nourishing yin, warming yang qi, and dispersing obstruction. These methods constituted an association with major syndrome factors. The major syndrome factors constituted an association with the following Chinese herbal medicines: Huangqi (Radix Astragali Mongolici), Chenpi (Pericarpium Citri Reticulatae), Dihuang (Radix Rehmanniae), Chuanxiong (Rhizoma Chuanxiong), Baizhu (Rhizoma Atractylodis Macrocephalae), Taoren (Semen Persicae), Fuling (Poria), Gancao (Radix Glycyrrhizae), Banxia (Rhizoma Pinelliae), Zexie (Rhizoma Alismatis), Chishao (Radix Paeoniae Rubra), Danggui (Radix Angelicae Sinensis), Danshen (Radix Salviae Miltiorrhizae), Zhiqiao (Fructus Aurantii Submaturus.), Guizhi (Ramulus Cinnamomi) and Maidong (Radix Ophiopogonis Japonici). The efficacy of Chinese berbal medicines constituting association with syndrome factors mainly included alleviating pain, resolving turbid and phlegm, clearing heat, activating blood circulation, invigorating qi, cooling blood, promoting urination, resolving stagnation, removing toxic material, nourishing blood, regulating qi, quieting spirit, invigorating spleen, regulating menstruation, promoting defecation, moistening dryness, and resolving stasis.
Conclusion

The therapeutic methods for CAD are based on consistency in theory, method, formula and medicines. Therapeutic methods for clearing heat and removing toxical material should be further studied.

Key words: Coronary artery disease, Therapeutic method, Syndrome, Medicine and prescription, Complex networks

Figure 1

Scattergram of relationship between syndrome and therapeutic treatment in CAD patients based on complex network"

Figure 2

Scattergram of relationship between syndrome and Chinese herb in CAD patients based on complex network"

Figure 3

Scattergram of relationship between syndrome and effectiveness in CAD patients based on complex network"

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