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Journal of Chinese Integrative Medicine ›› 2012, Vol. 10 ›› Issue (11): 1254-1262.doi: 10.3736/jcim20121109

• Original Clinical Research • Previous Articles     Next Articles

Quantitative evaluation of the degrees of traditional Chinese medicine qualitative syndromes of osteoporosis

Dong-tao Li1(), Jian Wang1, Hong-yang Jiang2, Feng-lei Shi3, Fu-yu Li4, Ji-hong Liu5, Yong-mei Cheng5, Nan Yan5, Ai-hua Hu6, Mei-zeng Zhang7,Jie 8, Ling-bo Wei8, Rong-qin Jiang9   

  1. 1. Department of Comprehensive Traditional Chinese Medicine, Second Sanitarium Area, Qingdao First Sanatorium, Jinan Military Region, Qingdao 266071, Shandong Province, China
    2. Department of Orthopedics, Centre Hospital of Haiyang, Haiyang 265100, Shandong Province, China
    3. Second Department of Orthopedics, Qingdao Orthopaedic and Traumatology Hospital, Qingdao 266021,Shandong Province, China
    4. Department of Traditional Chinese Medicine, Qingdao First Sanatorium, Jinan Military Region, Qingdao 266071, Shandong Province, China
    5. Physical Examination Center, Qingdao First Sanatorium, Jinan Military Region, Qingdao 266071,Shandong Province, China
    6. Qingdao Social Welfare Institution, Qingdao 266071, Shandong Province, China
    7. Department of Neurology, Affiliated Hospital of Qingdao University Medical College, Qingdao 266071, Shandong Province, China
    8. Department of Chinese Traditional Cardiology, Qingdao HaiCi Medical Group, Qingdao 266033, Shandong Province, China
    9. Department of Medical Services, Qingdao Integrated Traditional Chinese and Western Medicine Hospital, Qingdao 266002, Shandong Province, China
  • Received:2012-06-22 Accepted:2012-07-15 Online:2012-11-20 Published:2018-11-15

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Objective: To establish a quantitative estimate model for diagnosing traditional Chinese medicine (TCM) syndromes of patients with osteoporosis.

Methods: Symptoms and signs of osteoporosis and methodology related to syndrome research were collected by reviewing medical literature.The symptoms and sighs were quantitatively classified into three, two or one category according to a 100-mm visual analog scale. Fuzzy comprehensive evaluation model of TCM qualitative syndromes was performed based on analytic hierarchy process. Then “Hall for Workshop of Metasynthetic Engineering” expert symposium was held on subjects of syndrome quantification method and weight of evaluation indices in different levels for developing the analysis model of common syndromes. For clinical verification, the created models were applied to patients with osteoporosis for discriminating syndromes. Syndrome of each patient was also identified by 8 experts major in integrative medicine treating osteoporosis for comparing the coincidence rate using a self-made clinical questionnaire.

Results: Through literature reviewing, symptoms and signs quantification and expert discussing, the authors formed estimate models of essence deficit, qi deficiency, yin deficiency, yang deficiency, and blood stasis. A total of 220 patients with osteoporosis were enrolled and filled the clinical questionnaire. All 8 experts completed and returned the questionnaire (1 760 cases), and 1 545 of them were filled in completely. Experts’ opinion on syndrome differentiation was exactly coincidence to estimate model in 611 cases and almost coincidence in 639 cases. The total coincidence rate reached to 94.05%.

Conclusion: The estimate model for syndrome differentiation of osteoporosis has a high-coincidence rate with the fuzzy evaluation from experts, with good rationality and feasibility, and is worthy of promotion in the clinical study.

Key words: osteoporosis, TCM science, symptom complex, clinical trials

Table 1

Optimizing matrix of qi deficiency syndrome"

Symptom X2-1 X2-2 X2-3 X2-4 X2-5
X2-1 1 1 4 4 7
X2-2 1 1 1 4 4
X2-3 1/4 1 1 1 4
X2-4 1/4 1/4 1 1 1
X2-5 1/7 1/4 1/4 1 1
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