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Journal of Chinese Integrative Medicine ›› 2012, Vol. 10 ›› Issue (6): 619-627.doi: 10.3736/jcim20120604

Special Issue: Traditional Chinese Medicine

• Study Protocol • Previous Articles     Next Articles

Clinical epidemiology survey of the traditional Chinese medicine etiology and syndrome differentiation of coronary artery disease: Study protocol of a multicenter trial

Ying-fei Bi1,2, Jing-yuan Mao1,2(), Xian-liang Wang1,2, Ya-zhu Hou1,2, Yi-zhu 2,3,Bin Soh Shan4, Bo-li Zhang2,5   

  1. 1. Department of Cardiovascular Diseases, the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    2. National Clinical Research Center of Traditional Chinese Medicine on Coronary Artery Disease, Tianjin 300193, China
    3. Department of Diagnosis, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    4. International Educational Center, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    5. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  • Received:2012-02-23 Accepted:2012-02-26 Online:2012-06-20 Published:2018-06-15
  • Contact: Jing-yuan Mao E-mail:jymao@126.com

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Background: Coronary artery disease (CAD), a common disease with high incidence and mortality rate, has seriously threatened the health and life of the public. Traditional Chinese medicine (TCM) has an important role in the prevention and treatment of this disease. Through clinical epidemiological survey, a deeper understanding of TCM etiology and syndrome characteristics in CAD would further improve clinical efficacy in the treatment of this disease.
Methods/design: The preliminary clinical questionnaire for TCM etiology and syndrome differentiation in CAD was designed after literature reviews and analysis. Through a series of clinical pre-surveys, expert consultation and demonstration, the formal TCM clinical epidemiology questionnaire on the etiology and syndrome differentiation in CAD was finalized, after which, the study protocol, inclusive and exclusive criteria and related quality control measures were prepared. The multiregional clinical epidemiological survey with more than 5 000 participants with CAD will be carried out in 41 TCM hospitals of China for investigating the TCM etiology and syndrome differentiation of CAD.
Discussion: Multiregion large sample size clinical epidemiology survey on TCM etiology and syndrome differentiation in CAD will provide further evidence in preventing CAD and improving the standardization process of syndrome research.

Key words: coronary artery disease, traditional Chinese medicine, etiological factors (TCM), symptom complex, epidemiologic studies, questionnaires, multicenter study, clinical protocols

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Code Partners
001 First Affiliated Hospital of Anhui University of Traditional Chinese Medicine
002 Dongfang Hospital of Beijing University of Chinese Medicine
003 Third Affiliated Hospital of Beijing University of Chinese Medicine
004 The Affiliated Hospital to Changchun University of Chinese Medicine
005 Teaching Hospital of Chengdu University of TCM
006 University Hospital of Gansu Traditional Chinese Medicine
007 Guangdong Second Provincial Traditional Chinese Medicine Hospital
008 Guangdong Hospital of Traditional Chinese Medicine
009 First Teaching Hospital of Guangzhou University of Chinese Medicine
010 The First Affiliated Hospital of Guangxi University of Chinese Medicine
011 Hainan Hospital of Traditional Chinese Medicine
012 TCM Hospital of Shijiazhuang City
013 The First Affiliated Hospital of Henan University of Traditional Chinese Medicine
014 The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine
015 Affilicated Hospital of Henan Province Chinese Medicine Research Institute
016 Henan Hospital of TCM (The Second Affiliated Hospital of Henan University of TCM)
017 Heilongjiang Academy of TCM
018 First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine
019 Wuhan Integrated TCM and Western Medicine Hospital.
020 First Affiliated Hospital of Hunan University of Traditional Chinese Medicine
021 Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine
022 Affiliated Hospital of Jiangxi College of Traditional Chinese Medicine
023 Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
024 Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
025 The Third Affiliated Hospital of Nanjing University of Traditional Chinese Medicine
026 Ningxia Institute of Traditional Chinese Medicine
027 Affiliated Hospital of Shandong University of Traditional Chinese Medicine
028 Shanxi Hospital of Traditional Chinese Medicine
029 Xi’an Hospital of Traditional Chinese Medicine
030 Shaanxi Hospital of Traditional Chinese Medicine
031 Second Affiliated Hospital of Shaanxi College of Traditional Chinese Medicine
032 Longhua Hospital of Shanghai University of Traditional Chinese Medicine
033 Shuguang Hospital of Shanghai University of Traditional Chinese Medicine
034 Yueyang Hospital of Integrated Traditional Chinese and Western Medicine of Shanghai University of Traditional Chinese Medicine
035 Beijing Hospital of Traditional Chinese Medicine of Capital Medical University
036 First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
037 Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine
038 Affiliated Hospital of Tianjin Chinese Medicine Research Institute
039 TCM Hospital of Xinjiang Medical University
040 Guang’anmen Hospital of China Academy of Chinese Medical Sciences
041 Xiyuan Hospital of China Academy of Chinese Medical Sciences

Figure 1

The general process of clinical epidemiology survey of TCM etiology and syndrome differentiation of CAD TCM: traditional Chinese medicine; CAD: coronary artery disease."

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