Journal of Chinese Integrative Medicine ›› 2011, Vol. 9 ›› Issue (11): 1179-1184.doi: 10.3736/jcim20111104
• Review • Previous Articles Next Articles
Icariin and its pharmaceutical efficacy: Research progress of molecular mechanism
Yang Chen, Jian-hua Huang, You Ning, Zi-yin Shen(
)
- Institute of Integrated Chinese and Western Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
| [1] |
Sun X, Sun X, Jin X, Zhang X, Liu C, Lei L, Jin L, Liu H . Icariin induces mouse embryonic stem cell differentiation into beating functional cardiomyocytes. Mol Cell Biochem. 2011; 349(1-2):117-123.
doi: 10.1007/s11010-010-0666-4 |
| [2] |
Liu B, Zhang H, Xu C, Yang G, Tao J, Huang J, Wu J, Duan X, Cao Y, Dong J . Neuroprotective effects of icariin on corticosterone-induced apoptosis in primary cultured rat hippocampal neurons. Brain Res. 2011 ; 1375:59-67.
doi: 10.1016/j.brainres.2010.12.053 |
| [3] |
Hsieh TP, Sheu SY, Sun JS, Chen MH, Liu MH . Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfal expression. Phytomedicine. 2010 ; 17(6):414-423.
doi: 10.1016/j.phymed.2009.08.007 |
| [4] |
Zeng KW, Fu H, Liu GX, Wang XM . Icariin attenuates lipopolysaccharide-induced microglial activation and resultant death of neurons by inhibiting TAK1/IKK/NF-k:B and JNK/p38 MAPK pathways. Int Immunopharmacol. 2010; 10(6) : 668-678.
doi: 10.1016/j.intimp.2010.03.010 |
| [5] |
Chen SR, Xu XZ, Wang YH, Chen JW, Xu SW, Gu LQ, Liu PQ . Icariin derivative inhibits inflammation through suppression of p38 mitogen-activated protein kinase and nuclear factor-κB pathways. Biol Pharm Bull. 2010; 33(8) : 1307-1313.
doi: 10.1248/bpb.33.1307 |
| [6] |
Ding L, Liang XG, Hu Y, Zhu DY, Lou YJ . Involvement of p38MAPK and reactive oxygen species in icariin- induced cardiomyocyte differentiation of murine embryonic stem cells in vitro. Stem Cells Dev. 2008; 17(4) : 751-760.
doi: 10.1089/scd.2007.0206 |
| [7] |
Wo Y, Zhu D, Yu Y, Lou Y . Involvement of NF-κB and AP-1 activation in icariin promoted cardiac differentiation of mouse embryonic stem cells. [J] Eur Pharmacol. 2008; 586(1-3):59-66.
doi: 10.1016/j.ejphar.2008.02.080 |
| [8] |
WangL, Zhang L, Chen ZB, Wu JY, Zhang X, Xu Y . Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1. [J] Eur Pharmacol. 2009; 609(1-3):40-44.
doi: 10.1016/j.ejphar.2009.03.033 |
| [9] |
Koizumi H, Yu J, Hashimoto R, Ouchi Y, Okabe T . Involvement of androgen receptor in nitric oxide production induced by icariin in human umbilical vein endothelial cells. FEBSLett. 2010; 584(11):2440-2444.
doi: 10.1016/j.febslet.2010.04.049 |
| [10] |
Li S, Dong P, Wang J, Zhang J, Gu J, Wu X, Wu W, Fei X, Zhang Z, Wang Y, Quan Z, Liu Y . Icariin, a natural flavonol glycoside, induces apoptosis in human hepatoma SMMC-7721 cells via a ROS/JNK-dependent mitochondrial pathway. Cancer Lett. 2010 ; 298 (2): 222-230.
doi: 10.1016/j.canlet.2010.07.009 |
| [11] |
Zeng KW, Ko H, Yang HO, Wang XM . Icariin attenuates β-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells. Neuropharmacology. 2010; 59(6):542-550.
doi: 10.1016/j.neuropharm.2010.07.020 |
| [12] |
Xu CQ, Liu BJ, Wu JF, Xu YC, Duan XH, Cao YX, Dong JC . Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-icB signaling pathway. [J] Eur Pharmacol. 2010 ; 642(1-2):146-153.
doi: 10.1016/j.ejphar.2010.05.012 |
| [13] |
Chung BH, Kim JD, Kim CK, Kim JH, Won MH, Lee HS, Dong MS, Ha KS, Kwon YG, Kim YM . Icariin stimulates angiogenesis by activating the MEK/ ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells. Biochem Biophys Res Commun. 2008; 376(2) : 404-408.
doi: 10.1016/j.bbrc.2008.09.001 |
| [14] |
Dell 5 Agli M, Galli GV, Dal Cero E, Belluti F, Matera R, Zironi E, Pagliuca G, Bosisio E . Potent inhibition of human phosphodiesterase-5 by icariin derivatives.[J] Nat Prod. 2008; 71(9):1513-1517.
doi: 10.1149/1.1390889 pmid: 18778098 |
| [15] |
Ning H, Xin ZC, Lin G, Banie L, Lue TF, Lin CS . Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology. 2006; 68(6):1350-1354.
doi: 10.1016/j.urology.2006.09.031 |
| [16] |
Liu WJ, Xin ZC, Xin H, Yuan YM, Tian L, Guo YL . Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats. [J] Asian Androl. 2005; 7(4):381-388.
doi: 10.1111/ajan.2005.7.issue-4 |
| [17] |
Xin ZC, Kim EK, Lin CS, Liu WJ, Tian L, Yuan YM, Fu J . Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. [J] Asian Androl. 2003; 5(1) : 15-18.
doi: 10.1080/01485010390129287 pmid: 12646997 |
| [18] |
Wang ZQ, Lou YJ . Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells. [J] Eur Pharmacol. 2004; 504(3):147-153.
doi: 10.1016/j.ejphar.2004.10.002 pmid: 155414167 |
| [19] |
Shen P, Guo BL, Gong Y, Hong DY, Hong Y, Yong EL . Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species. Phytochemistry. 2007 ; 68(10):1448-1458.
doi: 10.1016/j.phytochem.2007.03.001 pmid: 17434191 |
| [20] |
Mok SK, Chen WF, Lai WP, Leung PC, Wang XL, Yao XS, Wong MS . Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells. [J] Br Pharmacol. 2010; 159(4):939-949.
doi: 10.1111/j.1476-5381.2009.00593.x |
| [21] |
Wu J, Du J, Xu C, Le J, Xu Y, Liu B, Dong J . Icariin attenuates social defeat-induced down-regulation of glucocorticoid receptor in mice. Pharmacol Biochem Behav. 2011; 98(2):273-278.
doi: 10.1016/j.pbb.2011.01.008 pmid: 21256148 |
| [22] | Zhu DY, Lou YJ . Inducible effects of icariin, icaritin, and desmethylicaritin on directional differentiation of embryonic stem cells into cardiomyocytes in vitro. 2005; 26(4) : 477-485. |
| [23] | Chen KM, Ge BF, Ma HP, Liu XY, Bai MH, Wang Y . Icariin, a flavonoid from the herb Epimedium enhances the osteogenic differentiation of rat primary bone marrow stromal cells. Pharmazie. 2005 ; 60(12):939-942. |
| [24] |
Zhao J, Ohba S, Shinkai M, Chung UI, Nagamune T . Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner. Biochem Biophys Res Commun. 2008; 369(2):444-448.
doi: 10.1016/j.bbrc.2008.02.054 pmid: 18295595 |
| [25] |
Ding L, Liang XG, Zhu DY, Lou YJ . Icariin promotes expression of PGC-lα, PPARα, and NRF-1 during cardiomyocyte differentiation of murine embryonic stem cells in vitro. Acta Pharmacol Sin. 2007 ; 28(10):1541-1549.
doi: 10.1111/aphs.2007.28.issue-10 |
| [26] | Zhang L, Huang S, Chen Y, Wang Z, Li E, Xu Y . Icariin inhibits hydrogen peroxide-mediated cytotoxicity by up-regulating sirtuin type 1-dependent catalase and peroxiredoxin. Basic Clin Pharmacol Toxicol. 2010 Aug 19. [Epub ahead of print] |
| [27] |
Wu J, Du J, Xu C, Le J, Liu B, Xu Y, Dong J . In vivo and in vitro anti-inflammatory effects of a novel derivative of icariin. Immunopharmacol Immunotoxicol. 2011 ; 33(1):49-54.
doi: 10.3109/08923971003725144 |
| [28] |
Shindel AW, Xin ZC, Lin G, Fandel TM, Huang YC, Banie L, Breyer BN, Garcia MM, Lin CS, Lue TF . Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (^Epimedium spp. ) in vitro and in vivo. J Sex Med. 2010; 7(4 Ptl):1518-1528.
doi: 10.1111/j.1743-6109.2009.01699.x |
| [29] |
Xu HB, Huang ZQ . Vasorelaxant effects of icariin on isolated canine coronary artery.[J] Cardiovase Pharmacol. 2007; 49(4) : 207-213.
doi: 10.1097/FJC.0b013e3180325abe pmid: 17438405 |
| [30] |
Johnsson K . Reflections on chemical biology. ACS Chem Biol. 2011; 6(1) : 1-2.
doi: 10.1021/cb100405m |
| [31] |
Allis CD, Muir TW . Spreading chromatin into chemical biology. Chembiochem. 2011; 12(2):264-279.
doi: 10.1002/cbic.201000761 pmid: 21243714 |
| [32] |
Bucci M, Goodman C, Sheppard TL . A decade of chemical biology. Nat Chem Biol. 2010; 6(12):847-854.
doi: 10.1038/nchembio.489 pmid: 21079586 |
| [33] |
Schimmer AD . Chemical biology — understanding biology and advancing therapy. Clin Invest Med. 2008; 31(5):E282-E289.
doi: 10.3727/096368908786576499 |
| [1] | Na Wu , Lu Song , Xin-xin Yang, Jiang-lei Wei , Zhen-guo Liu. Effects of Chinese herbal medicine Tianqi Pingchan Granule on G protein-coupled receptor kinase 6 involved in the prevention of levodopa-induced dyskinesia in rats with Parkinson disease. Journal of Chinese Integrative Medicine, 2012, 10(9): 1018-1024. |
| [2] | Avijit Paul, Kausik Bishayee, Samrat Ghosh, Avinaba Mukherjee, Sourav Sikdar, Debrup Chakraborty, Naoual Boujedaini, Anisur Rahman Khuda-Bukhsh. Chelidonine isolated from ethanolic extract of Chelidonium majus promotes apoptosis in HeLa cells through p38-p53 and PI3K/AKT signalling pathways. Journal of Chinese Integrative Medicine, 2012, 10(9): 1025-1038. |
| [3] | Lan He , Dong Li , Ying-sheng Xu. Target points: A discussion on acupuncture treatment of primary trigeminal neuralgia. Journal of Chinese Integrative Medicine, 2012, 10(9): 961-965. |
| [4] | Dong-mei Zhang, Li-xia Lou, Ai-ming Wu, Xi-ying Lü, Zhao-juan Hu, Yan-hong Zhang, Hong-fang Liu. Effects of Astragalus membranaceus and Potentilla discolor mixture on insulin resistance and its related mRNA expressions in KKAy mice with type 2 diabetes. Journal of Chinese Integrative Medicine, 2012, 10(7): 821-826. |
| [5] | Wei-hua Xu, Ze-huai Wen, Wei-xiong Liang, Qi Wang. A review of research on the development of instruments for therapeutic efficacy evaluation of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(7): 726-737. |
| [6] | Mei-jiao Mao, Jun-ping Hu, Cong Wang, Yi-yi Zhang, Ping Liu. Effects of Chinese herbal medicine Guanxinkang on expression of PPARγ-LXRα-ABCA1 pathway in ApoE-knockout mice with atherosclerosis. Journal of Chinese Integrative Medicine, 2012, 10(7): 814-820. |
| [7] | Daniel A. Weber, Janelle M. Wheat , Geoffrey M. Currie. Cancer stem cells and the impact of Chinese herbs, isolates and other complementary medical botanicals: A review. Journal of Chinese Integrative Medicine, 2012, 10(5): 493-503. |
| [8] | Qing-lan Wang, Yan-yan Tao , Li Shen , Hong-yan Cui , Cheng-hai Liu. Chinese herbal medicine Fuzheng Huayu recipe inhibits liver fibrosis by mediating the transforming growth factor-β1/Smads signaling pathway. Journal of Chinese Integrative Medicine, 2012, 10(5): 561-568. |
| [9] | De-bo Qi, Wei-min Li. Effects of electroacupuncture on expression of c-fos protein and N-methyl-D-aspartate receptor 1 in the rostral ventromedia medulla of rats with chronic visceral hyperalgesia. Journal of Chinese Integrative Medicine, 2012, 10(4): 416-423. |
| [10] | Gerhard Litscher. High-tech acupuncture made in Austria — cerebral circulation. Journal of Chinese Integrative Medicine, 2012, 10(4): 362-368. |
| [11] | Jin-bin Han, Yong-qiang Hua, Lian-yu Chen, Lu-ming Liu . Advances in Smoothened-targeting therapies for pancreatic cancer: Implication for drug discovery from herbal medicines. Journal of Chinese Integrative Medicine, 2012, 10(3): 256-263. |
| [12] | Satish Patel, Vikas Sharma, Nagendra S. Chauhan, Vinod K. Dixit. An updated review on the parasitic herb of Cuscuta reflexa Roxb. Journal of Chinese Integrative Medicine, 2012, 10(3): 249-255. |
| [13] | Zhuo-xin Yang, Peng-dian Chen, Hai-bo Yu, Min Pi, Wen-shu Luo, Yuan-yuan Zhuo . Study strategies for acupuncture treatment of chronic nonbacterial prostatitis. Journal of Chinese Integrative Medicine, 2012, 10(3): 293-297. |
| [14] | Li-xin Ma, Yu-yi Wang, Xin-xue Li, Jian-ping Liu . Systematic review on methodology of randomized controlled trials of post-marketing Chinese patent drugs for treatment of type 2 diabetes. Journal of Chinese Integrative Medicine, 2012, 10(3): 279-292. |
| [15] | Da-rong Wu . Modern testing theory and its application in the field of health measurement. Journal of Chinese Integrative Medicine, 2012, 10(3): 271-278. |