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Journal of Chinese Integrative Medicine ›› 2011, Vol. 9 ›› Issue (11): 1179-1184.doi: 10.3736/jcim20111104
• Review • Previous Articles Next Articles
Yang Chen, Jian-hua Huang, You Ning, Zi-yin Shen(
)
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Sun X, Sun X, Jin X, Zhang X, Liu C, Lei L, Jin L, Liu H . Icariin induces mouse embryonic stem cell differentiation into beating functional cardiomyocytes. Mol Cell Biochem. 2011; 349(1-2):117-123.
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Liu B, Zhang H, Xu C, Yang G, Tao J, Huang J, Wu J, Duan X, Cao Y, Dong J . Neuroprotective effects of icariin on corticosterone-induced apoptosis in primary cultured rat hippocampal neurons. Brain Res. 2011 ; 1375:59-67.
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Hsieh TP, Sheu SY, Sun JS, Chen MH, Liu MH . Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfal expression. Phytomedicine. 2010 ; 17(6):414-423.
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Zeng KW, Fu H, Liu GX, Wang XM . Icariin attenuates lipopolysaccharide-induced microglial activation and resultant death of neurons by inhibiting TAK1/IKK/NF-k:B and JNK/p38 MAPK pathways. Int Immunopharmacol. 2010; 10(6) : 668-678.
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Chen SR, Xu XZ, Wang YH, Chen JW, Xu SW, Gu LQ, Liu PQ . Icariin derivative inhibits inflammation through suppression of p38 mitogen-activated protein kinase and nuclear factor-κB pathways. Biol Pharm Bull. 2010; 33(8) : 1307-1313.
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Ding L, Liang XG, Hu Y, Zhu DY, Lou YJ . Involvement of p38MAPK and reactive oxygen species in icariin- induced cardiomyocyte differentiation of murine embryonic stem cells in vitro. Stem Cells Dev. 2008; 17(4) : 751-760.
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Wo Y, Zhu D, Yu Y, Lou Y . Involvement of NF-κB and AP-1 activation in icariin promoted cardiac differentiation of mouse embryonic stem cells. [J] Eur Pharmacol. 2008; 586(1-3):59-66.
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WangL, Zhang L, Chen ZB, Wu JY, Zhang X, Xu Y . Icariin enhances neuronal survival after oxygen and glucose deprivation by increasing SIRT1. [J] Eur Pharmacol. 2009; 609(1-3):40-44.
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Koizumi H, Yu J, Hashimoto R, Ouchi Y, Okabe T . Involvement of androgen receptor in nitric oxide production induced by icariin in human umbilical vein endothelial cells. FEBSLett. 2010; 584(11):2440-2444.
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Li S, Dong P, Wang J, Zhang J, Gu J, Wu X, Wu W, Fei X, Zhang Z, Wang Y, Quan Z, Liu Y . Icariin, a natural flavonol glycoside, induces apoptosis in human hepatoma SMMC-7721 cells via a ROS/JNK-dependent mitochondrial pathway. Cancer Lett. 2010 ; 298 (2): 222-230.
doi: 10.1016/j.canlet.2010.07.009 |
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Zeng KW, Ko H, Yang HO, Wang XM . Icariin attenuates β-amyloid-induced neurotoxicity by inhibition of tau protein hyperphosphorylation in PC12 cells. Neuropharmacology. 2010; 59(6):542-550.
doi: 10.1016/j.neuropharm.2010.07.020 |
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Xu CQ, Liu BJ, Wu JF, Xu YC, Duan XH, Cao YX, Dong JC . Icariin attenuates LPS-induced acute inflammatory responses: involvement of PI3K/Akt and NF-icB signaling pathway. [J] Eur Pharmacol. 2010 ; 642(1-2):146-153.
doi: 10.1016/j.ejphar.2010.05.012 |
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Chung BH, Kim JD, Kim CK, Kim JH, Won MH, Lee HS, Dong MS, Ha KS, Kwon YG, Kim YM . Icariin stimulates angiogenesis by activating the MEK/ ERK- and PI3K/Akt/eNOS-dependent signal pathways in human endothelial cells. Biochem Biophys Res Commun. 2008; 376(2) : 404-408.
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Liu WJ, Xin ZC, Xin H, Yuan YM, Tian L, Guo YL . Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats. [J] Asian Androl. 2005; 7(4):381-388.
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Xin ZC, Kim EK, Lin CS, Liu WJ, Tian L, Yuan YM, Fu J . Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities. [J] Asian Androl. 2003; 5(1) : 15-18.
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Wang ZQ, Lou YJ . Proliferation-stimulating effects of icaritin and desmethylicaritin in MCF-7 cells. [J] Eur Pharmacol. 2004; 504(3):147-153.
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Mok SK, Chen WF, Lai WP, Leung PC, Wang XL, Yao XS, Wong MS . Icariin protects against bone loss induced by oestrogen deficiency and activates oestrogen receptor-dependent osteoblastic functions in UMR 106 cells. [J] Br Pharmacol. 2010; 159(4):939-949.
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Wu J, Du J, Xu C, Le J, Xu Y, Liu B, Dong J . Icariin attenuates social defeat-induced down-regulation of glucocorticoid receptor in mice. Pharmacol Biochem Behav. 2011; 98(2):273-278.
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