[an error occurred while processing this directive]

Journal of Chinese Integrative Medicine ›› 2012, Vol. 10 ›› Issue (5): 504-507.doi: 10.3736/jcim20120504

• Methodology • Previous Articles     Next Articles

The balance principle in scientific research

Liang-ping Hu(), Xiao-lei Bao, Qi Wang#br#   

  1. Consulting Center of Biomedical Statistics, Academy of Military Medical Sciences, Beijing 100850, China
  • Received:2012-03-22 Accepted:2012-03-25 Online:2012-05-20 Published:2018-06-15
  • Contact: Hu Liang-ping E-mail:lphu812@sina.com

RichHTML

1

PDF (PC)

103

Like

The principles of balance, randomization, control and repetition, which are closely related, constitute the four principles of scientific research. The balance principle is the kernel of the four principles which runs through the other three. However, in scientific research, the balance principle is always overlooked. If the balance principle is not well performed, the research conclusion is easy to be denied, which may lead to the failure of the whole research. Therefore, it is essential to have a good command of the balance principle in scientific research. This article stresses the definition and function of the balance principle, the strategies and detailed measures to improve balance in scientific research, and the analysis of the common mistakes involving the use of the balance principle in scientific research.

Key words: statistics, medical, research design, balance principle

"

Group n VEGF positive index VEGF mRNA Apoptotic index
The 6th week The 12th week The 6th week The 12th week The 6th week The 12th week
Control 10 1.50±0.55 1.29±0.39 1.05±0.27 0.98±0.07 0.23±0.04 0.23±0.06
Dexamethasone 10 0.79±0.20 0.72±0.16 0.49±0.17 0.35±0.23 0.62±0.07 0.62±0.10
Chinese herbal medicine 10 1.09±0.26 1.05±0.28 0.85±0.62 0.79±0.47 0.33±0.02 0.33±0.03

"

Using dexameth- Using the VEGF positive index VEGF mRNA Apoptotic index
asoneor not Chinese herbal
medicine or not The 6th week The 12th week The 6th week The 12th week The 6th week The 12th week
No No 1.50±0.55 1.29±0.39 1.05±0.27 0.98±0.07 0.23±0.04 0.23±0.06
Yes – – – – – –
Yes No 0.79±0.20 0.72±0.16 0.49±0.17 0.35±0.23 0.62±0.07 0.62±0.10
Yes 1.09±0.26 1.05±0.28 0.85±0.62 0.79±0.47 0.33±0.02 0.33±0.03
[1] Hu LP. Research design and statistical analysis on stomatology[M]. Beijing: People’s Military Medical Press, 2007: 108-112.
胡良平 . 口腔医学科研设计与统计分析[M]. 北京: 人民军医出版社, 2007: 108-112.
[2] Hu LP, Li ZJ, Liu HG . Discrimination and analysis of statistical mistakes in medical papers(17): the understanding of the principles of experimental design[J]. Zhonghua Yi Xue Za Zhi, 2004,84(17):1481-1482.
doi: 10.3760/j:issn:0376-2491.2004.15.021
胡良平, 李子建, 刘惠刚 . 医学论文中统计分析错误辨析与释疑(17)——试验设计原则的正确把握[J]. 中华医学杂志, 2004,84(17):1481-1482.
doi: 10.3760/j:issn:0376-2491.2004.15.021
[3] Xu TH, Wang J . Experimental design of medical research: chapter 4, the principle of balance[J]. Zhongguo Yi Kan, 2005,40(10):57-58.
doi: 10.3969/j.issn.1008-1070.2005.10.025
徐天和, 王玖 . 医学试验设计:第四讲均衡原则[J]. 中国医刊, 2005,40(10):57-58.
doi: 10.3969/j.issn.1008-1070.2005.10.025
[4] Hu LP. Research design and statistical analysis in laboratory medicine[M]. Beijing: People’s Military Medical Press, 2004: 14-18.
胡良平 . 检验医学科研设计与统计分析[M]. 北京: 人民军医出版社, 2004: 14-18.
[5] Shen HS, Chen CW, Li YM, Chen YQ . Effects of nourishing yin clearing heat Chinese herbal medicine on vascular endothelial growth factor in the epiphyseal cartilage of growth retardation[J]. Zhongguo Gu Shang, 2009,22(1):14-16.
沈欢嗣, 陈朝蔚, 李玉梅, 陈永强 . 滋阴清热中药对生长延滞中骺板软骨细胞血管内皮生长因子表达的影响[J]. 中国骨伤, 2009,22(1):14-16.
[1] Wei-Jun Zhang, Da-Ming Su , Ka-Kit Hui. The development and current status of integrative medicine at UCLA. Journal of Chinese Integrative Medicine, 2012, 10(9): 953-960.
[2] Liang-ping Hu, Xiao-lei Bao, Chen-long Lv. Two-factor designs unable to examine the interactions (Part 2). Journal of Chinese Integrative Medicine, 2012, 10(9): 966-969.
[3] Ming T. Tan , Jian-ping Liu , Lixing Lao. Adequate application of quantitative and qualitative statistic analytic methods in acupuncture clinical trials. Journal of Chinese Integrative Medicine, 2012, 10(8): 847-852.
[4] Fan Yin, Ziyi Fan. Dr. Wu: A beautiful, moving and meditative song — In memory of Dr. Jing Nuan Wu, a pioneer of acupuncture and a Chinese medicine doctor in the United States. Journal of Chinese Integrative Medicine, 2012, 10(8): 837-840.
[5] Liang-ping Hu, Xiao-lei Bao, Chen-yi Guo . Two-factor designs unable to examine the interactions (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(8): 853-857.
[6] Claudia Maria Sous, Mario Goncalves, Jorge Machado, Thomas Efferth, Tobias Greten , Petra Froeschen , Henry J. Greten. Effects of qigong on performance-related anxiety and physiological stress functions in transverse flute music schoolchildren: A feasibility study. Journal of Chinese Integrative Medicine, 2012, 10(8): 858-865.
[7] Liang-ping Hu , Xiao-lei Bao, Chen-long Lü . How to choose an appropriate experimental design type (Part 2). Journal of Chinese Integrative Medicine, 2012, 10(7): 738-742.
[8] David Sibbritt, Pamela van der Riet, Saowapa Dedkhard, Kannapatch Srithong. Rehabilitation of stroke patients using traditional Thai massage, herbal treatments and physical therapies. Journal of Chinese Integrative Medicine, 2012, 10(7): 743-750.
[9] C. Matos Luís, J. Goncalves Mário, R. Silva António, G. Mendes Joaquim, P. Machado Jorge, J. Greten Henry. Assessment of Qigong-related effects by infrared thermography: A case study. Journal of Chinese Integrative Medicine, 2012, 10(6): 663-666.
[10] Liang-ping Hu, Xiao-lei Bao. How to choose an appropriate experimental design type (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(6): 615-618.
[11] Qing-hui Zhou . Assessment of research papers in medical university staff evaluation. Journal of Chinese Integrative Medicine, 2012, 10(6): 707-711.
[12] Yathiraj Ashwini, Mohamed Rafiq, Gollapalle L. Viswanatha, Subbanna Rajesh, Selvam Senthilraja, Mohammed Azeemuddin, Suryakanth D. Anturlikar, Paramesh Rangesh, Pralhad S. Patki . Polyherbal formulation Bresol® protects the mast cells against compound 48/80-induced disruption and histamine release: A non-immunological mechanism of mast cell stabilization. Journal of Chinese Integrative Medicine, 2012, 10(6): 690-694.
[13] Fan Yin . The first acupuncture center in the United States: An interview with Dr. Yao Wu Lee, Washington Acupuncture Center. Journal of Chinese Integrative Medicine, 2012, 10(5): 481-492.
[14] Qin-hui Fu, Jian Pei, Qi Jia, Yi Song, Yue-hua Gu, Xiao-xin You . Acupuncture treatment programs for post-stroke motor rehabilitation in community hospitals: Study protocol of a multicenter, randomized, controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(5): 516-524.
[15] Christoph A. Doenitz, Ana Anjos, Thomas Efferth , Tobias Greten, Henry J. Greten. Can heat and cold be parameterized? Clinical data of a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(5): 532-537.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Jin-rong Fu. Establishment of multivariate diagnosis and treatment system of modern gynecology of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 22-24
[2] Hao Li, Ming-jiang Yao, Wen-ming Zhao, Jie Guan, Lin-lin Cai, Ling Cui. A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment. Journal of Chinese Integrative Medicine, 2008, 6(1): 25-31
[3] Zhi-chun Jin. Problems in establishing clinical guideline for integrated traditional Chinese and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 5-8
[4] SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[5] Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[6] Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[7] Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074
[8] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[9] Gui Yu, Jie Wang. Thinking on building the network cardiovasology of Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(11): 1206-1210
[10] Pedro Saganha João, Doenitz Christoph, Greten Tobias, Efferth Thomas, J. Greten Henry. Qigong therapy for physiotherapists suffering from burnout: a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(11): 1233-1239
[an error occurred while processing this directive]