科研设计应遵守均衡原则

doi:10.3736/jcim20120504

Abstract

The principles of balance, randomization, control and repetition, which are closely related, constitute the four principles of scientific research. The balance principle is the kernel of the four principles which runs through the other three. However, in scientific research, the balance principle is always overlooked. If the balance principle is not well performed, the research conclusion is easy to be denied, which may lead to the failure of the whole research. Therefore, it is essential to have a good command of the balance principle in scientific research. This article stresses the definition and function of the balance principle, the strategies and detailed measures to improve balance in scientific research, and the analysis of the common mistakes involving the use of the balance principle in scientific research.

Key words: statistics, medical, research design, balance principle

Liang-ping Hu, Xiao-lei Bao, Qi Wang . The balance principle in scientific research. Journal of Chinese Integrative Medicine, 2012, 10(5): 504-507.

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Group	n	VEGF positive index		VEGF mRNA		Apoptotic index
Group	n	The 6th week	The 12th week	The 6th week	The 12th week	The 6th week	The 12th week
Control	10	1.50±0.55	1.29±0.39	1.05±0.27	0.98±0.07	0.23±0.04	0.23±0.06
Dexamethasone	10	0.79±0.20	0.72±0.16	0.49±0.17	0.35±0.23	0.62±0.07	0.62±0.10
Chinese herbal medicine	10	1.09±0.26	1.05±0.28	0.85±0.62	0.79±0.47	0.33±0.02	0.33±0.03

Using dexameth-	Using the	VEGF positive index		VEGF mRNA		Apoptotic index
asoneor not	Chinese herbal	VEGF positive index		VEGF mRNA		Apoptotic index
	medicine or not	The 6th week	The 12th week	The 6th week	The 12th week	The 6th week	The 12th week
No	No	1.50±0.55	1.29±0.39	1.05±0.27	0.98±0.07	0.23±0.04	0.23±0.06
	Yes	–	–	–	–	–	–
Yes	No	0.79±0.20	0.72±0.16	0.49±0.17	0.35±0.23	0.62±0.07	0.62±0.10
	Yes	1.09±0.26	1.05±0.28	0.85±0.62	0.79±0.47	0.33±0.02	0.33±0.03

The balance principle in scientific research

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