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Journal of Chinese Integrative Medicine ›› 2010, Vol. 8 ›› Issue (11): 1070-1074.doi: 10.3736/jcim20101111

• Original Experimental Research • Previous Articles     Next Articles

Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure

Jing-yuan Maoa, Chang-xiao Liub, Heng-he Wanga,Guang-li Wei b, Zhen-peng Zhangc,Jie Xing d,Wang Xian liang a,Ying-fei Bie   

  1. a Department of Cardiology, the First Affiliated Hospital, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
    b Tianjin State Key Laboratory of Phartrmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China
    c Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;
    d School of Pharmacy, Shandong University, Jinan 250100, Shandong Province, China
    e Postgraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
  • Received:2010-03-05 Accepted:2010-06-22 Online:2010-11-20 Published:2010-11-15
  • Contact: Jing-yuan Mao E-mail:jymao@126. com

Objective

To explore the effects of Shenmai Injection (SMI), a compound traditional Chinese herbal medicine, on pharmacokinetics and serum concentration of digoxin when applied together with digoxin.

Methods

Twenty dogs with heart failure were randomly divided into 4 groups: control group and low-, medium- and high-dose SMI groups, with 5 dogs in each group. After intravenous injection of digoxin injection at a dose of 7.41 μg/kg, dogs in the control group were administered intravenously with normal saline 20 mL daily for 5 d, and the other groups were intravenously administered with SMI at the doses of 0.517, 1.034 and 1.551 mL/kg respectively. After the administration, the blood was collected at designed time points. Serum concentration of digoxin was determined by high-performance liquid chromatography with electrospray tandem mass spectrometry (HPLC/MS/MS).

Results

he low-, medium- and high-dose SMI showed different effects on the pharmacokinetics of digoxin: the low-, medium- and high-dose SMI revealed a tendency to decrease the elimination half-life (T1/2β) of digoxin. The low-dose SMI showed a tendency to decrease the digoxin concentration. Serum clearance (CL) in the low-dose SMI group was higher than that in the control, and also significantly higher than those in the medium- and high-dose SMI groups (P<0.05). The area under concentration-time curve (AUC0→∞) in the low-dose SMI group was lower than that in the control group (P=0.05); the AUC0→72 h and AUC0→∞ in the low-dose SMI group were significantly lower than those in the medium- and high-dose SMI groups. Low-dose SMI accelerated the clearance of digoxin in blood.

Conclusion

Low-, medium- and high-dose SMI shows different effects on pharmacokinetics of digoxin and reveals a tendency to shorten T1/2β of digoxin. Low-dose SMI can accelerate the clearance of digoxin in blood.

Key words: Shenmai Injection, Heart failure, Digoxin, Pharmacokinetics, Dogs

Table 1

Serum concentrations of digoxin in four groups of dogs with heart failure"

Figure 1

Semi-logarithmic curve of concentration-time of digoxin"

Table 2

Pharmacokinetic parameters of digoxin in four groups of dogs with heart failure"

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