Interventional mechanisms of herbs or herbal extracts on renal interstitial fibrosis

doi:10.1016/S2095-4964(16)60256-X

Abstract

Renal interstitial fibrosis (RIF) is a common development in chronic renal diseases that can lead to uremia and be life-threatening. The RIF pathology has complicated extracellular and intercellular mechanisms, involving many cells and cytokines, resulting in an incomplete mechanistic understanding of the disease. Finding effective herbs or herbal extracts for prevention and treatment of RIF is crucial because current medical approaches do not reliably slow or reverse RIF. In recent years, many experts have worked to identify herbs or herbal extracts to combat RIF both in vivo and in vitro, with some success. This review attempts to summarize the possible interventional mechanisms of herbs or herbal extracts involved in protecting and reversing RIF. The authors found some herbs and their extracts that may ameliorate renal impairments through anti-inflammation, anti-fibrogenesis and stabilization of extra cellular matrix. Among them, tetramethylpyrazine/ligustrazine, curcumin and polyglucoside of Tripterygium have experimentally shown good potential for improving RIF. However, conclusive evidence is still needed, especially in randomized controlled clinical trials. We expect that herbs or herbal extracts will play an important role in RIF treatment and reversal in the future.

Key words: Renal interstitial Fibrosis, Plant extracts, Drugs, Chinese herbal, Review

JiaXia, Li-qunHe, XiaoSu. Interventional mechanisms of herbs or herbal extracts on renal interstitial fibrosis. Journal of Integrative Medicine, 2016, 14(3): 165-173.

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References

1 Atta HM.Reversibility and heritability of liver fibrosis: implications for research and therapy. World [J] Gastroenterol. 2015; 21(17): 5138-5148.
2 Gaje PN, Stoia-Djeska I, Cimpean AM, Ceausu RA, Tudorache V, Raica M.Lymphangiogenesis as a prerequisite in the pathogenesis of lung fibrosis. In Vivo. 2014; 28(3): 367-373.
3 Harris RC, Neilson EG.Toward a unified theory of renal progression. Annu Rev Med. 2006; 57: 365-380.
4 Vanherweghem LJ.Misuse of herbal remedies: the case of an outbreak of terminal renal failure in Belgium (Chinese herbs nephropathy). J Altern Complement Med. 1998; 4(1): 9-13.
5 Zhang JP. Prohibition of drug production containing Aristolochiae lignum. China Times.2003-2-27(11).
6 Zhao AQ, Ma CG, Zhao S. Salvia miltiorrhiza injection ameliorates renal interstitial fibrosis in unilateral ureteral obstruction rats. Shanxi Yi Yao Za Zhi.2007; 36(9): 785- 787. Chinese with abstract in English.
7 Wu R, Zhou Q, Lin S, Ao X, Chen X, Yang J. Effect of Cordceps sinensis on the expression of ICAM-1 and VCAM-1 in the kidney of spontaneously hypertensive rats. Zhong Nan Da Xue Xue Bao Yi Xue Ban.2010; 35(2): 152-158. Chinese with abstract in English.
8 Pan MM, Zhang MH, Ni HF, Chen JF, Xu M, Phillips AO, Liu BC.Inhibition of TGF-β1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats. Food Chem Toxicol. 2013; 58: 487-494.
9 Genovese F, Manresa AA, Leeming DJ, Karsdal MA, Boor P.The extracellular matrix in the kidney: a source of novel non-invasive biomarkers of kidney fibrosis? Fibrogenesis Tissue Repair. 2014; 7(1): 4.
10 Edyy AA.Molecular basis of renal fibrosis. Pediatr Nephrol. 2000; 15(3-4): 290-301.
11 Barnes JL, Glass WF 2nd. Renal interstitial fibrosis: a critical evaluation of the origin of myofibroblasts. Contrib Nephrol. 2011; 169: 73-93.
12 Peng DD, Cheng LP. Progress in research of renal tubular epithelial cell injury. Lin Chuang Er Ke Za Zhi.2013; 31(6): 584-587. Chinese with abstract in English.
13 Veerasamy M, Nguyen TQ, Motazed R, Pearson AL, Goldschmeding R, Dockrell ME.Differential regulation of E-cadherin and α-smooth muscle actin by BMP 7 in human renal proximal tubule epithelial cells and its implication in renal fibrosis. Am [J] Physiol Renal Physiol. 2009; 297(5): F1238-F1248.
14 Wick W, Platten M, Weller M.Glioma cell invasion: regulation of metalloproteinase activity by TGF-β. [J] Neurooncol. 2001; 53(2): 177-185.
15 Scotton CJ, Chambers RC.Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest. 2007; 132(4): 1311-1321.
16 Boor P, Ostendorf T, Floege J.Renal fibrosis: novel insights into mechanisms and therapeutic targets. Nat Rev Nephrol. 2010; 6(11): 643-656.
17 Gordon KJ, Blobe GC.Role of transforming growth factor-β superfamily signaling pathways in human disease. Biochim Biophys Acta. 2008; 1782(4): 197-228.
18 Docherty NG, O’Sullivan OE, Healy DA, Murphy M, O’neill AJ, Fitzpatrick JM, Watson RW. TGF-β1-induced EMT can occur independently of its proapoptotic effects and is aided by EGF receptor activation. Am [J] Physiol Renal Physiol. 2006; 290(5): F1202-F1212.
19 Wu CF, Chiang WC, Lai CF, Chang FC, Chen YT, Chou YH, Wu TH, Linn GR, Ling H, Wu KD, Tsai TJ, Chen YM, Duffield JS, Lin SL.Transforming growth factor β-1 stimulates profibrotic epithelial signaling to activate pericyte-myofibroblast transition in obstructive kidney fibrosis. Am [J] Pathol. 2013; 182(1): 118-131.
20 Derynck R, Zhang YE.Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature. 2003; 425(6958): 577-584.
21 Chevalier RL.Obstructive nephropathy: towards biomarker discovery and gene therapy. Nat Clin Pract Nephrol. 2006; 2(3): 157-168.
22 Li Y, Sun Y, Liu F, Sun L, Li J, Duan S, Liu H, Peng Y, Xiao L, Liu Y, Xi Y, You Y, Li H, Wang M, Wang S, Hou T.Norcantharidin inhibits renal interstitial fibrosis by blocking the tubular epithelial-mesenchymal transition. PLoS One. 2013; 8(6): e66356.
23 Böttinger EP, Bitzer M.TGF-β signaling in renal disease. [J] Am Soc Nephro. 2002; 13(10): 2600-2610.
24 Phanish MK, Wahab NA, Colville-Nash P, Hendry BM, Dockrell ME.The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFβ1 responses in human proximal-tubule epithelial cells. Biochem J. 2006; 393(Pt 2): 601-607.
25 Peinado H, Quirtanilla M, Cano A.Transforming growth factor β-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. [J] Biol Chem. 2003; 278(23): 21113-21123.
26 Kolosova I, Nethery D, Kern JA.Role of Smad2/3 and p38 MAP kinase in TGF-β1-induced epithelial-mesenchymal transition of pulmonary epithelial cells. [J] Cell Physiol. 2011; 226(5): 1248-1254.
27 K i m K H, P a r k J H, L e e W R, P a r k J S, K i m H C, Park KK. The inhibitory effect of chimeric decoy oligodeoxynucleotide against NF-κB and Sp1 in renal interstitial fibrosis. J Mol Med (Berl). 2013; 91(5): 573-586.
28 Chen X, Zhouhua W, Jie Z, Xinlu F, Jinqiang L, Yuwen Q, Zhiying H.Renal interstitial fibrosis induced by high-dose mesoporous silica nanoparticles via the NF-κB signaling pathway. Int [J] Nanomedicine. 2014; 10: 1-22.
29 Catania JM, Chen G, Parrish AR.Role of matrix metalloproteinases in renal pathophysiologies. Am [J] Physiol Renal Physiol. 2007; 292(3): F905-F911.
30 Visse R, Nagase H.Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res. 2003; 92(8): 827-839.
31 Jin YM, Chen N. JAK/STAT signal in renal interstitial fibrosis. Shen Zang Bing Yu Tou Xi Shen Yi Zhi Za Zhi.2012; 21(3): 255-259. Chinese with abstract in English.
32 Pang M, Ma L, Gong R, Tolbert E, Mao H, Ponnusamy M, Chin YE, Yan H, Dworkin LD, Zhuang S.A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy. Kidney Int. 2010; 78(3): 257-268.
33 Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R.BMP-7 counteracts TGF-β1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med. 2003; 9(7): 964-968.
34 Grgic I, Duffield JS, Humphreys BD.The origin of interstitial myofibroblasts in chronic kidney disease. Pediatr Nephrol. 2012; 27(2): 183-193.
35 Liu Y.New insights into epithelial-mesenchymal transition in kidney fibrosis. [J] Am Soc Nephrol. 2010; 21(2): 212-222.
36 Cho ME, Kopp JB.Pirfenidone: an anti-fibrotic therapy for progressive kidney disease. Expert Opin Investig Drugs. 2010; 19(2): 275-283.
37 Wang YC, Jin QM, Kong WZ, Chen J.Protective effect of salvianolic acid B on NASH rat liver through restoring intestinal mucosal barrier function. Int [J] Clin Exp Pathol. 2015; 8(5): 5203-5209.
38 Wang QL, Tao YY, Yuan JL, Shen L, Liu CH.Salvianolic acid B prevents epithelial-to-mesenchymal transition through the TGF-β1 signal transduction pathway in vivo and in vitro. BMC Cell Biol. 2010; 11: 31.
39 Lu HY, Zhang Y, Liu YM, Lu M, Zhou J, Liu KJ, Li J. Influence of salvianolic acid B on expression of MMP-2 in renal fibrosis rats. Shanghai Zhong Yi Yao Da Xue Xue Bao.2009; 23(2): 55-58. Chinese with abstract in English.
40 Lü YJ, Sun JP, Gao YX, Wang YQ. Effect of tanshinone II-A sulfonate on rats with renal interstitial fibrosis and its mechanisms. Shandong Yi Yao.2014; 54(10): 30-32. Chinese.
41 Sun XW, Cao L, Yu GH, Zhang X, Guo QX, Guo Y. Effect of sodium tanshinone II-A sulfonate on human renal interstitial fibrocytes of UUO and the expression of cyclin D1. Luzhou Yi Xue Yuan Xue Bao.2007; 30(2): 95-98. Chinese with abstract in English.
42 Tang J, Zhan C, Zhou J.Effects of tanshinone IIA on transforming growth factor β1-smads signal pathway in renal interstitial fibroblasts of rats. [J] Huazhong Univ Sci Technolog Med Sci. 2008; 28(5): 539-542.
43 Yuan XP, Liu LS, Fu Q, Wang CX.Effects of ligustrazine on ureteral obstruction-induced renal tubulointerstitial fibrosis. Phytother Res. 2012; 26(5): 697-703.
44 Lu M, Zhou J, Wang F, Liu Y, Zhang Y. Effect of tetramethylpyrazine on expression of Smad7 and SnoN in rats with UUO. Zhongguo Zhong Yao Za Zhi.2009; 34(1): 84-88. Chinese with abstract in English.
45 Li JZ, Yu JD, Liu YM, Hu L, Liu LJ, Zhou XT, Mo WJ. Effects of ligustrazine on expression of MMP-9 and TIMP-1 in rats with renal interstitial fibrosis. Yi Xue Li Lun Yu Shi Jian.2012; 25(3): 249-251. Chinese with abstract in English.
46 Cheng CY, Sue YM, Chen CH, Hou CC, Chan P, Chu YL, Chen TH, Hsu YH.Tetramethylpyrazine attenuates adriamycin-induced apoptotic injury in rat renal tubular cells NRK-52E. Planta Med. 2006; 72(10): 888-893.
47 Zhou X, Zhang J, Xu C, Wang W.Curcumin ameliorates renal fibrosis by inhibiting local fibroblast proliferation and extracellular matrix deposition. [J] Pharmacol Sci. 2014; 126(4): 344-350
48 Kuwabara N, Tamada S, Iwai T, Teramoto K, Kaneda N, Yukimura T, Nakatani T, Miura K.Attenuation of renal fibrosis by curcumin in rat obstructive nephropathy. Urology. 2006; 67(2): 440-446.
49 Li Y, Chen ZQ, Li YD. Effects of curcumin on the epithelial mesenchymal transition and TGF-β/Smads signaling pathway in unilateral ureteral obstruction rats. Zhongguo Zhong Xi Yi Jie He Za Zhi.2011; 31(9): 1224-1228. Chinese with abstract in English.
50 Wang M, Fan JM, Liu XY. Effect of total saponins of Panax notoginseng on transdifferentiation of rats’ tubular epithetlial cell induced by IL-1α. Zhongguo Zhong Xi Yi Jie He Za Zhi.2004; 24(8): 722-725. Chinese with abstract in English.
51 Su BH, Li Z, Fan JM, Wang M, Tang R. Effects of Panax notoginseng saponins on the process of renal interstitial fibrosis after unilateral ureteral obstruction in rats. Sichuan Da Xue Xue Bao Yi Xue Ban.2005; 36(3): 368-371. Chinese with abstract in English.
52 Li XB, Bian Z, Lan P. Effect of safflower on expression of kidney NAG, NF-кB, TGF-β1 of rats with unilateral ureteral obstruction. Henan Zhong Yi.2011; 31(6): 604-606. Chinese with abstract in English.
53 Yang YL, Chang SY, Teng HC, Liu YS, Lee TC, Chuang LY, Guh JY, Chang FR, Liao TN, Huang JS, Yeh JH, Chang WT, Hung MY, Wang CJ, Chiang TA, Hung CY, Hung TJ.Safflower extract: a novel renal fibrosis antagonist that functions by suppressing autocrine TGF-β. [J] Cell Biochem. 2008; 104(3): 908-919.
54 Zuo C, Xie XS, Deng Y, Fan JM. Effect of Astragalus mongholicus on expression of connective tissue growth factor in kidney of SD rats with unilateral ureteral obstruction. Zhong Yao Cai.2008; 31(8): 1185-1190. Chinese with abstract in English.
55 Zeng JY, He F, Wang Y, Ding HY, Tong JR, Luo ZM. Effects of Astragalus mongholicus on expression of snail in rats with cyclosporin A-induced nephropathy. Guangdong Yi Xue.2011; 32(8): 953-956. Chinese with abstract in English.
56 Dai Q, Qu XL, Tang YH, Li HP. Protective effects of Astragalus polysaccharides on 5/6 nephrectomy rats. Jiangsu Zhong Yi Yao.2014; 46(6): 75-76. Chinese.
57 Lu X, Wei MG. Effects of Astragalus polysaccharides on renal interstitial fibrosis in rats. Zhonghua Zhong Yi Yao Za Zhi.2014; 29(6): 1998-2001. Chinese with abstract in English.
58 Xu W, Shao X, Tian L, Gu L, Zhang M, Wang Q, Wu B, Wang L, Yao J, Xu X, Mou S, Ni Z.Astragaloside IV ameliorates renal fibrosis via the inhibition of mitogen-activated protein kinases and antiapoptosis in vivo and in vitro. [J] Pharmacol Exp Ther. 2014; 350(3): 552-562.
59 Wang L, Chi YF, Yuan ZT, Zhou WC, Yin PH, Zhang XM, Peng W.Astragaloside IV inhibits the up-regulation of Wnt/β-catenin signaling in rats with unilateral ureteral obstruction. Cell Physiol Biochem. 2014; 33(5): 1316-1328.
60 Chai JJ, Chen YP, Rui HL. Effects of Hirsutella sinensis on TGF-β1 and Snail expressions and transdifferentiation of tubular epithelial-myofibroblast in renal tissue of rats with chronic aristolochic acid nephropathy. Zhongguo Zhong Xi Yi Jie He Za Zhi.2009; 29(4): 325-329. Chinese with abstract in English.
61 Wu JN, Liu BC, Xia HL, Liu DG. Effect of Cordyceps polysaccharide on the tubular epithelial-mesenchymal transition in mice with unilateral ureteral obstruction. Zhongguo Zhong Xi Yi Jie He Shen Bing Za Zhi.2008; 9(5): 400-402. Chinese with abstract in English.
62 Zeng J, Dou Y, Guo J, Wu X, Dai Y.Paeoniflorin of Paeonia lactiflora prevents renal interstitial fibrosis induced by unilateral ureteral obstruction in mice. Phytomedicine. 2013; 20(8-9): 753-759.
63 Xiang Z, Sun H, Cai X, Chen D, Zheng X.The study on the material basis and the mechanism for anti-renal interstitial fibrosis efficacy of rhubarb through integration of metabonomics and network pharmacology. Mol Biosyst. 2015; 11(4): 1067-1078.
64 He D, Lee L, Yang J, Wang X.Preventive effects and mechanisms of rhein on renal interstitial fibrosis in obstructive nephropathy. Biol Pharm Bull. 2011; 34(8): 1219-1226.
65 Su J, Yin LP, Zhang X, Li BB, Liu L, Li H.Chronic allograft nephropathy in rats is improved by the intervention of rhein. Transplant Proc. 2013; 45(6): 2546-2552.
66 Gao Q, Qin WS, Jia ZH, Zheng JM, Zeng CH, Li LS, Liu ZH.Rhein improves renal lesion and ameliorates dyslipidemia in db/db mice with diabetic nephropathy. Planta Med. 2010; 76(1): 27-33.
67 Chen TF, Chen M, Qin JH, Wang MY. Interventional effects of emodin on transforming growth factor-β1/integrin-linked kinase signal way in interleukin-1β-induced transdifferentiation of rat tubular epithelial-myofibroblasts. J Chin Integr Med.2009; 7(1): 59-64. Chinese with abstract in English.
68 Wang R, Wan Q, Zhang Y, Huang F, Yu K, Xu D, Wang Q, Sun J.Emodin suppresses interleukin-1β induced mesangial cells proliferation and extracellular matrix production via inhibiting P38 MAPK. Life Sci. 2007; 80(26): 2481-2488.
69 Bai Y, Lu H, Zhang G, Wu C, Lin C, Liang Y, Chen B.Sedum sarmentosum Bunge extract exerts renal anti-fibrotic effects in vivo and in vitro. Life Sci. 2014; 105(1-2): 22-30.
70 Xie HD, Yang K, Mu HD, Wei SD, Zhang YY, Liu CH. Effect of Scutellaria baicalensis extract on rats with renal interstitial fibrosis and its antioxidation mechanism. Zhongguo Zhong Xi Yi Jie He Shen Bing Za Zhi.2009; 10(3): 240-242. Chinese.
71 Wang WY, Guo Z, Sun SJ, Dai JY, Cao HJ, Zheng NN, Fang JW, Gou XJ, Lu X, Zhang YY. Intervention effect of baicalein on the expression of TGF-β1, Smad-2 of renal interstitial fibrosis in rats. Changchun Zhong Yi Yao Da Xue Xue Bao.2012; 28(3): 383-385. Chinese.
72 Yuan XP, He XS, Wang CX, Liu LS, Fu Q.Triptolide attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction. Nephrology (Carlton). 2011; 16(2): 200-210.
73 Wan YG, Sun W, Dou CH. Effect of multi-glycoside of Tripterygium wilfordii Hook. f. in intervening TGF-β1/Smad signaling pathway of adriamycin-induced nephropathy model rat. Zhongguo Zhong Xi Yi Jie He Za Zhi.2011; 31(4): 517-524. Chinese with abstract in English.
74 Zhao C, Yu W, Ren X, Zhang W, Li H. Effects of Tripterygium wilfordii polyglucoside on expression of activin A and influence of transdifferentiation in renal tubulointerstitium of rats with diabetic nephropathy. Zhonghua Yi Xue Za Zhi.2014; 94(18): 1427-1432. Chinese with abstract in English.
75 Yang RC, Wang YJ, Zhou DW, Wang J, Zhu X. Effects of Tripterygium Wilfordii on renal interstitial fibrosis and inflamed lesion in UUO mice kidney. Zhongguo Mian Yi Xue Za Zi.2007; 23(4): 322-325. Chinese with abstract in English.
76 Liu SF, Chang SY, Lee TC, Chuang LY, Guh JY, Hung CY, Hung TJ, Hung YJ, Chen PY, Hsieh PF, Yang YL.Dioscorea alata attenuates renal interstitial cellular fibrosis by regulating Smad- and epithelial-mesenchymal transition signaling pathways. PLoS One. 2012; 7(11): e47482.
77 Hu Y, Lin FL, Zou QL, Mou LJ. Effect of Coicis semen oil on renal interstitial fibrosis in rats with unilateral urethral obstruction. Zhongguo Zhong Yao Za Zhi.2013; 38(12): 1982-1986. Chinese with abstract in English.
78 Eddy AA.Can renal fibrosis be reversed? Pediatr Nephrol. 2005; 20(10): 1369-1375.

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