A cross-sectional study of complementary and alternative medicine use in patients with coagulation disorders in Southern Iran

doi:10.1016/S2095-4964(17)60343-1

Abstract

Objective

Complementary and alternative medicine (CAM) use has an increasing trend around the world. Despite the wild application of CAM in patients with coagulation disorders, its efficacy is still questioned by many studies. The aim of this study was to determine the frequency and types of CAM usage, and the factors affecting CAM use among patients with bleeding disorders.

Methods

This cross-sectional study investigated the usage of CAM with a standard validated questionnaire in coagulopathic patients who were referred to Dastgheib Hospital, an educational therapeutic center affiliated to the Shiraz University of Medical Sciences in Shiraz, Southern Iran.

Results

Between December 2015 and May 2016, 75 patients were included in this survey. Severe hemophilia A and rare bleeding disorders were the most frequent among our participants. Overall, nearly half of the studied population (49.3%) used at least one CAM product or practices. The most common products were multivitamin (29.3%), followed by folic acid (21.3%) and chamomile (12%). 32% of the patients resorted to faith healing. The main reasons of using CAM were reported to be increased general health, correction of anemia and thrombocytopenia and control of bleeding tendency.

Conclusion

CAM is being used frequently in patients with coagulation disorders like many other chronic illnesses all around the world. Due to emerging concern regarding the safety and possible interaction with the conventional medicine, it is necessary to develop basic data about the hematologic effects of these methods in order to use them more safely.

Key words: Medicine, Traditional, Complementary medicine, Alternative therapies, Coagulation disorder, Hemophilia, Iran

Mohammadreza Bordbar, Mehdi Pasalar, Rezvan Aresehiri, Sezaneh Haghpanah, Soheila Zareifar, Fatemeh Amirmoezi. A cross-sectional study of complementary and alternative medicine use in patients with coagulation disorders in Southern Iran. Journal of Integrative Medicine, 2017, 15(5): 359-364.

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References

1 Hashempur MH, Heydari M, Mosavat SH, Heydari ST, Shams M.Complementary and alternative medicine use in Iranian patients with diabetes mellitus.J Integr Med. 2015; 13(5): 319-325.
2 Fisher P, Ward A.Complementary medicine in Europe.BMJ. 1994; 309(6947): 107-111.
3 Jakovljevic MB, Djordjevic V, Markovic V, Milovanovic O, Rancic NK, Cupara SM.Cross-sectional survey on complementary and alternative medicine awareness among health care professionals and students using CHBQ questionnaire in a Balkan country.Chin J Integr Med. 2013; 19(9): 650-655.
4 Frenkel MA, Borkan JM.An approach for integrating complementary-alternative medicine into primary care.Fam Pract. 2003; 20(3): 324-332.
5 Kessler RC, Davis RB, Foster DF, Van Rompay MI, Walters EE, Wilkey SA, Kaptchuk TJ, Eisenberg DM.Long-term trends in the use of complementary and alternative medical therapies in the United States.Ann Intern Med. 2001; 135(4): 262-268.
6 Lagunju IA.Complementary and alternative medicines use in children with epilepsy in Ibadan, Nigeria.Afr J Med Med Sci. 2013; 42(1): 15-23.
7 Rancic N, Jakovljevic MM.Long term health spending alongside population aging in N-11 emerging nations.East Eur Bus Econ J. 2016; 2(1): 22-26.
8 Clarke TC, Black LI, Stussman BJ, Barnes PM, Nahin RL.Trends in the use of complementary health approaches among adults: United States, 2002-2012.Natl Health Stat Report. 2015; 10(79): 11-16.
9 Pharm SMCR, Djordjevic V, Jakovljevic MB.Current legal status and research on complementary and alternative medicine in Serbia.J Altern Med Res. 2013; 5(3): 195.
10 Peyvandi F, Mannucci PM, Garagiola I, El-Beshlawy A, Elalfy M, Ramanan V, Eshghi P, Hanagavadi S, Varadarajan R, Karimi M, Manglani MV, Ross C, Young G, Seth T, Apte S, Nayak DM, Santagostino E, Mancuso ME, Sandoval Gonzalez AC, Mahlangu JN, Bonanad Boix S, Cerqueira M, Ewing NP, Male C, Owaidah T, Soto Arellano V, Kobrinsky NL, Majumdar S, Perez Garrido R, Sachdeva A, Simpson M, Thomas M, Zanon E, Antmen B, Kavakli K, Manco-Johnson MJ, Martinez M, Marzouka E, Mazzucconi MG, Neme D, Palomo Bravo A, Paredes Aguilera R, Prezotti A, Schmitt K, Wicklund BM, Zulfikar B, Rosendaal FR.A randomized trial of factor VIII and neutralizing antibodies in hemophilia A.N Engl J Med. 2016; 374(21): 2054-2064.
11 Bolton-Maggs PH, Pasi KJ.Haemophilias A and B.Lancet. 2003; 361(9371): 1801-1809.
12 Roy S, Ghadially FN.Synovial membrane in experimentallyproduced chronic haemarthrosis.Ann Rheum Dis. 1969; 28(4): 402-414. 13. Kundu T, Shaikh T, Singh P, Sheikh A, Kumat O, Kulkarni S, Kulkarni R, Nalavade A, Patil A, Ghosh K. Management of acute bleeding in severe haemophilia using homeopathic medicines: a multicentric case series. J Homeop Ayurv Med. 2015; 4:180.
14 Jadhav U, Mukherjee K, Thakur H.Usage of complementary and alternative medicine among severe hemophilia A patients in India.J Evid Based Complement Altern Med. 2013; 18(3): 191-197.
15 Cordier W, Steenkamp V.Herbal remedies affecting coagulation: a review.Pharm Biol. 2012; 50(4): 443-452.
16 Beyazit Y, Kurt M, Kekilli M, Goker H, Haznedaroglu IC.Evaluation of hemostatic effects of Ankaferd as an alternative medicine.Altern Med Rev. 2010; 15(4): 329-336.
17 Adams D, Dagenais S, Clifford T, Baydala L, King WJ, Hervas-Malo M, Moher D, Vohra S.Complementary and alternative medicine use by pediatric specialty outpatients.Pediatrics. 2013; 131(2): 225-232.
18 Escobar MA.Advances in the treatment of inherited coagulation disorders.Haemophilia. 2013; 19(5): 648-659.
19 Norred CL, Brinker F.Potential coagulation effects of preoperative complementary and alternative medicines.Altern Ther Health Med. 2001; 7(6): 58.
20 Lillicrap D.Introduction to a series of reviews on inherited bleeding disorders.Blood. 2015; 125(13): 2011.
21 Jansen NW, Roosendaal G, Lafeber FP.Understanding haemophilic arthropathy: an exploration of current open issues.Br J Haematol. 2008; 143(5): 632-640.
22 Karimi M, Rahmani S, Ardeshiri R, Pasalar M.Health status in Iranian haemophilic patients.Haemophilia. 2008; 14(3): 615-617.
23 Hacioglu SK, Dogu MH, Sari I, Keskin A.Successful treatment of refractory gastrointestinal bleeding by systemic (oral) Ankaferd Blood Stopper in a patient with Glanzmann thrombasthenia.Balkan Med J. 2015; 32(2): 218-220.
24 Akkoc N, Akcelik M, Haznedaroglu IC, Goker H, Turgut M, Aksu S, Kirazli S, Firat HC.In vitro anti-bacterial activities of Ankaferd medicinal plant extract. Turkiye Klinikleri Tip Bilimleri Dergisi. 2009; 29(2): 410-415.
25 Fisgin NT, Cayci YT, Coban AY, Ozatli D, Tanyel E, Durupinar B, Tulek N.Antimicrobial activity of plant extract Ankaferd Blood Stopper.Fitoterapia. 2009; 80(1): 48-50.
26 Chen C, Yang FQ, Zhang Q, Wang FQ, Hu YJ, Xia ZN.Natural products for antithrombosis.Evid Based Complement Alternat Med. 2015; 2015: 876426.
27 Pruthi R, Schmidt K, Slaby J, Rodriguez V.Platelet dysfunction induced by herbal supplements in a patient with mild hemophilia A.J Thrombosis Haemostasis. 2007; 5(12): 2556-2558.
28 Roozbeh J, Hashempur MH, Heydari M.Use of herbal remedies among patients undergoing hemodialysis.Iran J Kidney Dis. 2013; 7(6): 492-495.
29 Ghazeeri GS, Awwad JT, Alameddine M, Younes ZM, Naja F.Prevalence and determinants of complementary and alternative medicine use among infertile patients in Lebanon: a crosssectional study.BMC Complement Altern Med. 2012; 12: 129.
30 Pasalar M, Lankarani KB.Herbal medicines, a prominent component in complementary and alternative medicine use in gastrointestinal field.Am J Gastroenterol. 2015; 110(6): 935.
31 Rosted P, Jørgensen V.Acupuncture used in the management of pain due to arthropathy in a patient with haemophilia.Acupunct Med. 2002; 20(4): 193-195.
32 Gomis M, Querol F, Gallach J, González L, Aznar J.Exercise and sport in the treatment of haemophilic patients: a systematic review.Haemophilia. 2009; 15(1): 43-54.
33 Varni JW, Gilbert A.Self-regulation of chronic arthritic pain and long-term analgesic dependence in a haemophiliac.Rheumatology. 1982; 21(3): 171-174.
34 Liu SX, Jiang L, Liang X, Kong WW, Chen J, Liu YG, He LQ.Study on graded therapy of hemophilic arthritis by integrative traditional Chinese and Western medicine.Chin J of Integr Med. 2007; 13(4): 301-305.
35 Namjooyan F, Ghanavati R, Majdinasab N, Jokari S, Janbozorgi M.Uses of complementary and alternative medicine in multiple sclerosis.J Tradit Complement Med. 2014; 4(3): 145-152.
36 McLean TW, Kemper KJ. Complementary and alternative medicine therapies in pediatric oncology patients.J Soc Integr Oncol. 2006; 4(1): 40-45.
37 Bordbar MR, Pasalar M, Safaei S, Kamfiroozi R, Zareifar S, Zekavat O, Haghpanah S. Complementary and alternative medicine use in thalassemia patients in Shiraz, southern Iran: a cross-sectional study. J Tradit Complement Med.2017; article in press.
38 Tonekaboni SH, Jafari Naeini S, Khajeh A, Yaghini O, Ghazavi A, Abdollah Gorji F.Use of complementary and alternative medicine for epileptic children in Tehran: a cross-sectional study (2009-2011).Iran J Child Neurol. 2014; 8(1): 26-31.
39 Farooqui M, Hassali MA, Shatar AKA, Farooqui MA, Saleem F, Haq NU, Othman CN.Use of complementary and alternative medicines among Malaysian cancer patients: a descriptive study.J Tradit Complement Med. 2016; 6(4): 321-326.
40 Fan AY.Nevada: the first state that fully legalized acupuncture and Chinese medicine in the Unites States—in memory of Arthur Steinberg, Yee Kung Lok and Jim Joyce who made it happen.J Integr Med. 2015; 13(2): 72-79.
41 Lambing A, Kohn-Converse B, Hanagavadi S, Varma V.Use of acupuncture in the management of chronic haemophilia pain.Haemophilia. 2012; 18(4): 613-617.
42 Izatt E, Fairman M.Staphylococcal septicaemia with disseminated intravascular coagulation associated with acupuncture.Postgrad Med J. 1977; 53(619): 285-286.
43 Hussain K.Serum hepatitis associated with repeated acupunctures.Br Med J. 1974; 3(5922): 41-42.
44 Keller WJ, Parker SG, Garvin JP.Possible renal complications of acupuncture.JAMA. 1972; 222(12): 1559-1560.
45 Ventola CL.Current issues regarding complementary and alternative medicine (CAM) in the United States: part 1: the widespread use of CAM and the need for better-informed health care professionals to provide patient counseling.P T. 2010; 35(8): 461-468.

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