Tumor microenvironment,medicine,Chinese traditional,Chinese medicine monomer,Chinese medicine compound,Research progress," /> Tumor microenvironment,medicine,Chinese traditional,Chinese medicine monomer,Chinese medicine compound,Research progress,"/> Progress in research on the effects of traditional Chinese medicine on the tumor microenvironment
Search JIM Advanced Search

Journal of Integrative Medicine ›› 2017, Vol. 15 ›› Issue (4): 282-287.doi: 10.1016/S2095-4964(17)60345-5

Special Issue: Traditional Chinese Medicine

• Review • Previous Articles     Next Articles

Progress in research on the effects of traditional Chinese medicine on the tumor microenvironment

Wan-fu Lina, Jian-ying Lub, Bin-bin Chenga, Chang-quan Linga   

  1. a Changhai Hospital of Traditional Chinese Medicine, Second Military Medical University, Shanghai 200433, China
    b Department of Traditional Chinese Medicine, Jing’an Hospital of Integrated Traditional Chinese and Western Medicine, Hefei 200040, Anhui Province, China
  • Received:2017-01-06 Accepted:2017-04-05 Online:2017-07-15 Published:2018-12-19
  • Contact: Prof. Chang-quan Ling; E-mail: changquanling@smmu.edu.cn
  • Supported by:
    This study was supported by the National Natural Science Foundation of China (No. 81430101) and the Special Fund for the Development of Traditional Chinese Medicine in Anhui Province in 2015.

Tumor microenvironment (TME) has received more and more attention as modern medical research has begun to understand its importance in tumorigenesis. The occurrence, development, metastasis and drug resistance of tumors are closely related to TME. TME is a complicated system, including nontumor cells, their secreted cytokines, extracellular matrix, among other components. The concepts of wholism and multitarget regulation in traditional Chinese medicine (TCM) make it well suited to the regulation of TME. In this paper, the authors reviewed the progress of TME research and the effect of TCM on TME, providing some views of Chinese medicine in antitumor research.

Key words: Tumor microenvironment, medicine, Chinese traditional, Chinese medicine monomer, Chinese medicine compound, Research progress

1 Ma Y, Yang H, Pitt JM, Kroemer G, Zitvogel L.Therapyinduced microenvironmental changes in cancer.J Mol Med (Berl). 2016; 94(5): 497-508.
2 Paget S.The distribution of secondary growths in cancer of the breast. 1889.Cancer Metastasis Rev. 1989; 8(2): 98-101.
3 Mathot L, Stenninger J.Behavior of seeds and soil in the mechanism of metastasis: a deeper understanding.Cancer Sci. 2012; 103(4): 626-631.
4 Wang X, Wang N, Cheung F, Lao L, Li C, Feng Y.Chinese medicines for prevention and treatment of human hepatocellular carcinoma: current progress on pharmacological actions and mechanisms.J Integr Med. 2015; 13(3): 142-164.
5 Ling CQ, Yue XQ, Ling C.Three advantages of using traditional Chinese medicine to prevent and treat tumor.J Integr Med. 2014; 12(4): 331-335.
6 Egeblad M, Nakasone ES, Werb Z.Tumors as organs: complex tissues that interface with the entire organism. Dev Cell.2010; 18(6): 884-901.
7 Ruddle NH.High endothelial venules and lymphatic vessels in tertiary lymphoid organs: characteristics, functions, and regulation.Front Immunol. 2016; 7: 491.
8 Tammela T, Alitalo K.Lymphangiogenesis: molecular mechanisms and future promise.Cell. 2010; 140(4): 460-476.
9 Rhee I.Diverse macrophages polarization in tumor microenvironment.Arch Pharm Res. 2016; 39(11): 1588-1596.
10 Gordon S, Plüddemann A, Martinez Estrada F.Macrophage heterogeneity in tissues: phenotypic diversity and functions.Immunol Rev. 2014; 262(1): 36-55.
11 Cao W, Peters JH, Nieman D, Sharma M, Watson T, Yu J.Macrophage subtype predicts lymph node metastasis in oesophageal adenocarcinoma and promotes cancer cell invasionin vitro. Br J Cancer. 2015; 113(5): 738-746.
12 Chen DS, Mellman I.Oncology meets immunology: the cancer-immunity cycle.Immunity. 2013; 39(1): 1-10.
13 Gardner A, Ruffell B.Dendritic cells and cancer immunity.Trends Immunol. 2016; 37(12): 855-865.
14 Zong J, Keskinov AA, Shurin GV, Shurin MR.Tumorderived factors modulating dendritic cell function.Cancer Immunol Immunother. 2016; 65(7): 821-833.
15 Cekic C, Day YJ, Sag D, Linden J.Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment.Cancer Res. 2014; 74(24): 7250-7259.
16 Sarhan D, Palma M, Mao Y, Adamson L, Kiessling R, Mellstedt H, Österborg A, Lundqvist A.Dendritic cell regulation of NK-cell responses involves lymphotoxin-α, IL-12, and TGF-β.Eur J Immunol. 2015; 45(6): 1783-1793.
17 Chaudhary B, Elkord E.Regulatory T cells in the tumor microenvironment and cancer progression: role and therapeutic targeting.Vaccines (Basel). 2016; 4(3): 28.
18 Otomo R, Otsubo C, Matsushima-Hibiya Y, Miyazaki M, Tashiro F, Ichikawa H, Kohno T, Ochiya T, Yokota J, Nakagama H, Taya Y, Enari M.TSPAN12 is a critical factor for cancer-fibroblast cell contact-mediated cancer invasion.Proc Natl Acad Sci U S A. 2014; 111(52): 18691-18696.
19 Dvorak HF.Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.N Engl J Med. 1986; 315(26): 1650-1659.
20 Cuiffo BG, Karnoub AE.Mesenchymal stem cells in tumor development: emerging roles and concepts.Cell Adh Migr. 2012; 6(3): 220-230.
21 Karnoub AE, Dash AB, Vo AP, Sullivan A, Brooks MW, Bell GW, Richardson AL, Polyak K, Tubo R, Weinberg RA.Mesenchymal stem cells within tumour stroma promote breast cancer metastasis.Nature. 2007; 449(7162): 557-563.
22 Au P, Tam J, Fukumura D, Jain RK.Bone marrow-derived mesenchymal stem cells facilitate engineering of longlasting functional vasculature.Blood. 2008; 111(9): 4551-4558.
23 Quante M, Tu SP, Tomita H, Gonda T, Wang SS, Takashi S, Baik GH, Shibata W, Diprete B, Betz KS, Friedman R, Varro A, Tycko B, Wang TC.Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth.Cancer Cell. 2011; 19(2): 257-272.
24 Paunescu V, Bojin FM, Tatu CA, Gavriliuc OI, Rosca A, Gruia AT, Tanasie G, Bunu C, Crisnic D, Gherghiceanu M, Tatu FR, Tatu CS, Vermesan S.Tumour-associated fibroblasts and mesenchymal stem cells: more similarities than differences.J Cell Mol Med. 2011; 15(3): 635-646.
25 Cocucci E, Meldolesi J.Ectosomes and exosomes: shedding the confusion between extracellular vesicles.Trends Cell Biol. 2015; 25(6): 364-372.
26 Mathivanan S, Ji H, Simpson RJ.Exosomes: extracellular organelles important in intercellular communication.J Proteomics. 2010; 73(10): 1907-1920.
27 Whiteside TL.Tumor-derived exosomes and their role in tumor-induced immune suppression.Vaccines (Basel). 2016; 4(4): 35.
28 Wang Z, Chen JQ, Liu JL, Tian L.Exosomes in tumor microenvironment: novel transporters and biomarkers.J Transl Med. 2016; 14(1): 297.
29 M’Boutchou MN, van Kempen LC. Analysis of the tumor microenvironment transcriptome via NanoString mRNA and miRNA expression profiling.Methods Mol Biol. 2016; 1458: 291-310.
30 Frediani JN, Fabbri M.Essential role of miRNAs in orchestrating the biology of the tumor microenvironment.Mol Cancer. 2016; 15(1): 42.
31 Böhme I, Bosserhoff AK.Acidic tumor microenvironment in human melanoma.Pigment Cell Melanoma Res. 2016; 29(5): 508-523.
32 Michiels C, Tellier C, Feron O.Cycling hypoxia: a key feature of the tumor microenvironment.Biochim Biophys Acta. 2016; 1866(1): 76-86.
33 Qian Q. Discussion on the treatment of cancer by traditional Chinese medicine. Zhejiang Zhong Xi Yi Jie He Za Zhi.2004; 14(6): 356-357. Chinese.
34 Zheng W, Yang JK. Tumor microenvironment and its TCM pathogenesis. Zhong Yi Za Zhi.2015; 56(20): 1720-1724. Chinese.
35 Owen S, Gao Y, Zhi X, Wei C, Wu Y, Jiang WG.Effect of Yangzheng Xiaoji extract, DME-25, on endothelial cells and their response to Avastin.Anticancer Res. 2016; 36(3): 1181-1192.
36 Min L, Ling W, Hua R, Qi H, Chen S, Wang H, Tang L, Shangguan W.Anti-angiogenic therapy for normalization of tumor vasculature: a potential effect of Buyang Huanwu decoction on nude mice bearing human hepatocellular carcinoma xenografts with high metastatic potential.Mol Med Rep. 2016; 13(3): 2518-2526.
37 Zhang EX, Zhou DH, Hou C. Effect of Yiqi Chutan Formula on antitumor immunity response through inhibiting production of tumor-associated macrophages. Zhonghua Zhong Liu Fang Zhi Za Zhi.2016; 23(10): 627-635. Chinese.
38 Luo Y, Wu J, Zhu X, Gong C, Yao C, Ni Z, Wang L, Ni L, Li Y, Zhu S.NK cell-dependent growth inhibition of Lewis lung cancer by Yu Ping Feng, an ancient Chinese herbal formula.Mediators Inflamm. 2016; 2016: 3541283.
39 Wang E, Bussom S, Chen J, Quinn C, Bedognetti D, Lam W, Guan F, Jiang Z, Mark Y, Zhao Y, Stroncek DF, White J, Marincola FM, Cheng YC.Interaction of a traditional Chinese medicine (PHY906) and CPT-11 on the inflammatory process in the tumor microenvironment.BMC Med Genomics. 2011; 4: 38.
40 Lam W, Jiang Z, Guan F, Huang X, Hu R, Wang J, Bussom S, Liu SH, Zhao H, Yen Y, Cheng YC.PHY906 (KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Sorafenib by changing the tumor microenvironment.Sci Rep. 2015; 5: 9384.
41 Liu J, Zhang J, Huang L, Zhu X, Chen W, Hu P.Xuefu Zhuyu Tang exerts antitumor effects by inhibiting glioma cell metastasis and invasion via regulating tumor microenvironment.Onco Targets Ther. 2016; 9: 3603-3612.
42 Xue YL, Meng XQ, Ma LJ, Yuan Z.Plumbagin exhibits an antiproliferative effect in human osteosarcoma cells by down-regulating FHL2 and interfering with Wnt/β-catenin signalling.Oncol Lett. 2016; 12(2): 1095-1100.
43 Su YC, Lin IH, Siao YM, Liu CJ, Yeh CC.Modulation of the tumor metastatic microenvironment and multiple signal pathways byPrunella vulgaris in human hepatocellular carcinoma. Am J Chin Med. 2016; 44(4): 835-849.
44 Wang N, Tan HY, Li L, Yuen MF, Feng Y.Berberine andCoptidis Rhizoma as potential anticancer agents: recent updates and future perspectives. J Ethnopharmacol. 2015; 176: 35-48.
45 Lin J, Li Q, Chen H, Lin H, Lai Z, Peng J.Hedyotis diffusa Willd. extract suppresses proliferation and induces apoptosis via IL-6-inducible STAT3 pathway inactivation in human colorectal cancer cells. Oncol Lett. 2015; 9(4): 1962-1970.
46 Zhou Z, Lu ZR. Molecular imaging of the tumor microenvironment. Adv Drug Deliv Rev.2016 Aug; Epub ahead of print.
[1] Tara Rajendran. Addressing the need for personalizing music therapy in integrative oncology. Journal of Integrative Medicine, 2022, 20(4): 281-283.
[2] Wan-jun Guo, Yi Wang, Yu Deng, Lin-yan Cheng, Xin Liu, Ruo-fan Xi, Sheng-jie Zhu, Xin-yi Feng, Liang Hua, Kan Ze, Jian-yong Zhu, Dong-jie Guo, Fu-lun Li. Therapeutic effects of the extract of Sancao Formula, a Chinese herbal compound, on imiquimod-induced psoriasis via cysteine-rich protein 61. Journal of Integrative Medicine, 2022, 20(4): 376-384.
[3] Cai-lian Fana, Wan-jun Caib, Meng-nan Ye, Miao Chen, Yi Dai. Qili Qiangxin, a compound herbal medicine formula, alleviates hypoxia-reoxygenation-induced apoptotic and autophagic cell death via suppression of ROS/AMPK/mTOR pathway in vitro. Journal of Integrative Medicine, 2022, 20(4): 365-375.
[4] Shang-jin Song, Xuan Liu, Qing Ji, Da-zhi Sun, Li-juan Xiu, Jing-yu Xu, Xiao-qiang Yue. Ziyin Huatan Recipe, a Chinese herbal compound, inhibits migration and invasion of gastric cancer by upregulating RUNX3 expression. Journal of Integrative Medicine, 2022, 20(4): 355-364.
[5] Vibha Malhotra, Joanna Harnett, Erica McIntyre, Amie Steel, Keith Wong, Bandana Saini. To “tell or not to tell”—Exploring disclosure about medicine use by people living with sleep disorders. Journal of Integrative Medicine, 2022, 20(4): 338-347.
[6] Maryam Azimi, Hanieh Niayesh, Mahboobeh Raeiszadeh, Sedigheh Khodabandeh-shahraki. Efficacy of the herbal formula of Foeniculum vulgare and Rosa damascena on elderly patients with functional constipation: A double-blind randomized controlled tria. Journal of Integrative Medicine, 2022, 20(3): 230-236.
[7] Marisa Casal. Improving the health and treatment success rates of in vitro fertilization patients with traditional chinese medicine: need for more robust evidence and innovative approaches. Journal of Integrative Medicine, 2022, 20(3): 187-192.
[8] Ning Guo, Fei Wu, Mei Wu, Yuan Wang, Qing Lang, Xiao Lin, Yi Feng. Progress in the design and quality control of placeboes for clinical trials of traditional Chinese medicine . Journal of Integrative Medicine, 2022, 20(3): 204-212.
[9] Tareq A. Wani, Zahoor A. Kaloo, Nisar A. Dangroo. Aconitum heterophyllum Wall. ex Royle: A critically endangered medicinal herb with rich potential for use in medicine. Journal of Integrative Medicine, 2022, 20(2): 104-113.
[10] Mohammad Fazil, Sadia Nikhat. Why the “sugars” in traditional Unani formulations are a pivotal component: A viewpoint perspective. Journal of Integrative Medicine, 2022, 20(2): 91-95.
[11] Yan-jun Lin, Kun-li Jiao, Bo Liu, Lu Fang, Shu Meng. Antiplatelet and myocardial protective effect of shexiang tongxin dropping pill in patients undergoing percutaneous coronary intervention: A randomized controlled trial. Journal of Integrative Medicine, 2022, 20(2): 126-134.
[12] Deng-chao Wang, Miao Yu, Wen-xian Xie, Li-yan Huang, Jian Wei, Yue-hua Lei. Meta-analysis on the effect of combining Lianhua Qingwen with Western medicine to treat coronavirus disease 2019. Journal of Integrative Medicine, 2022, 20(1): 26-33.
[13] Mahlagha Dehghan, Alireza Ghanbari, Fatemeh Ghaedi Heidari, Parvin Mangalian, Mohammad Ali Zakerid. Use of complementary and alternative medicine in general population during COVID-19 outbreak: A survey in Iran. Journal of Integrative Medicine, 2022, 20(1): 45-51.
[14] Jose Antonio Castilla-Jimena, Isabel Ruiz-Pérez, Jesús Henares-Montiel. Impact of socioeconomic and health-related factors on consumption of homeopathic and natural remedies in Spain in 2006, 2011 and 2017. Journal of Integrative Medicine, 2022, 20(1): 52-56.
[15] Ofer Baranovitch, Meirav Wolff-Bar, Meora Feinmesser, Chen Sade-Zaltz, Ilan Tsarfaty, Victoria Neiman. Searching for the emotional roots of breast cancer: A cross-disciplinary analysis integrating psychology, Chinese medicine, and oncology biomarkers. Journal of Integrative Medicine, 2022, 20(1): 57-64.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228