Search JIM Advanced Search

Journal of Integrative Medicine ›› 2020, Vol. 18 ›› Issue (1): 27-.doi: 10.1016/j.joim.2019.11.006

• Original Clinical Research • Previous Articles     Next Articles

Effects of the use of bioceramic wraps in patients with lower limb venous ulcers: A randomized double-blind placebo-controlled trial

Gerli E.G. Herra, Fábio Goulart da Silvaa, Francisco José Cidral-Filhob, Fabricia Petronilhoc, Lucinéia Gainski Danielskic, Mariana Pereira de Souza Goldimc, Afonso Shiguemi Inoue Salgadob,d, Franciane Bobinskib, Daniel Fernandes Martinsb, Eliane R. Winkelmanna,e   

  1. a. Integral Health Care, Regional University of the Northwest of the State of Rio Grande do Sul (UNIJUÍ) and University of Cruz Alta (UNICRUZ), Ijuí, 98700-000, RS, Brazil
    b. Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina, Palhoça, 88137-270, SC, Brazil
    c. Laboratory of Neurobiology of Inflammatory and Metabolic Processes, University of Southern Santa Catarina, Tubarão, 88704-900, SC, Brazil.
    d. Integrative Physical Therapy Residency, Philadelphia University Center, Londrina, 86020-000, PR, Brazil
    e. Laboratory of Exercise Physiopathology, Department of Life Sciences (DCVida), Regional University of the Northwest of the State of Rio Grande do Sul (UNIJUÍ), Ijuí, 98700-000, RS, Brazil

  • Online:2020-01-15 Published:2019-11-15


Venous ulcer represents the most advanced stage of chronic venous insufficiency. It is an important public health problem and has a significant impact on patients’ quality of life due to chronic pain, inability to work, need for hospitalization and frequent outpatient follow-up.


We investigated the treatment benefits of far-infrared ceramic (cFIR), in a 90-day study of lower limb venous ulcers and looked atulcer healing scores, quality of life, serum bio-markers of oxidative stress and antioxidant defense enzymes.

Design, setting, participants and interventions

This is a randomized double-blind placebo-controlled study conducted in the Vascular Surgery Service of a hospital located in the northwest region of the State of Rio Grande do Sul, Brazil. We included patients with lower limb venous ulcers who were randomized to use either a bioceramics wrap or a placebo wrap for 90 days.

Main outcome measures

The following evaluations were conducted at baseline and after 15, 30, 60 and 90 days: ulcer healing score, quality of life, and serum markers of oxidative stress and antioxidant enzyme activity.


Patients (n = 24) with lower limb venous ulcers were randomized into two treatment groups. cFIR decreased the ulcer size on day 30 (P = 0.042) and 90 (P = 0.034) and the total ulcer healing scale scores on day 30 (P = 0.049) and 90 (P = 0.02) of the treatment, when compared to baseline. Additionally, cFIR improved tissue type (epithelial tissue) on day 60 (= 0.022) when compared to baseline evaluation.


cFIR clinically improved ulcer healing in patients with lower limb venous ulcers.

Trial registration

RBR-8c7xzn on ReBEC.

Key words: Far-infrared radiation, Quality of life, Oxidative stress, Wound healing, Randomized controlled trial,  Bioceramic wrap

No related articles found!
Full text



[1] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[2] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[3] Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76
[4] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[5] Bo Wang , Wei Yan , Li-hui Hou, Xiao-ke Wu. Disorder of Tiangui (kidney essence) and reproductive dysfunction in patients with polycystic ovary syndrome. Journal of Chinese Integrative Medicine, 2010, 8(11): 1018-1022
[6] Wei Xu, Meng Shi, Jian-gang Liu, Cheng-long Wang . Collagen protein expressions in ischemic myocardium of rats with acute myocardial infarction and effects of qi-tonifying, yin-tonifying and blood-activating herbs and detoxifying and blood-activating herbs. Journal of Chinese Integrative Medicine, 2010, 8(11): 1041-1047
[7] Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[8] Gui Yu, Jie Wang. Thinking on building the network cardiovasology of Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(11): 1206-1210
[9] Peng-fei Gao, Kenji Watanabe. Introduction of the World Health Organization project of the International Classification of Traditional Medicine. Journal of Chinese Integrative Medicine, 2011, 9(11): 1161-1164
[10] Li-ke Guo, Chao-xian Zhang, Xiao-feng Guo. Acupuncture combined with Chinese herbal medicine Plantain and Senna Granule in treatment of functional constipation: A randomized, controlled trial. Journal of Chinese Integrative Medicine, 2011, 9(11): 1206-1214