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Journal of Integrative Medicine ›› 2020, Vol. 18 ›› Issue (1): 27-.doi: 10.1016/j.joim.2019.11.006

• Original Clinical Research • Previous Articles     Next Articles

Effects of the use of bioceramic wraps in patients with lower limb venous ulcers: A randomized double-blind placebo-controlled trial

Gerli E.G. Herra, Fábio Goulart da Silvaa, Francisco José Cidral-Filhob, Fabricia Petronilhoc, Lucinéia Gainski Danielskic, Mariana Pereira de Souza Goldimc, Afonso Shiguemi Inoue Salgadob,d, Franciane Bobinskib, Daniel Fernandes Martinsb, Eliane R. Winkelmanna,e   

  1. a. Integral Health Care, Regional University of the Northwest of the State of Rio Grande do Sul (UNIJUÍ) and University of Cruz Alta (UNICRUZ), Ijuí, 98700-000, RS, Brazil
    b. Experimental Neuroscience Laboratory (LaNEx), University of Southern Santa Catarina, Palhoça, 88137-270, SC, Brazil
    c. Laboratory of Neurobiology of Inflammatory and Metabolic Processes, University of Southern Santa Catarina, Tubarão, 88704-900, SC, Brazil.
    d. Integrative Physical Therapy Residency, Philadelphia University Center, Londrina, 86020-000, PR, Brazil
    e. Laboratory of Exercise Physiopathology, Department of Life Sciences (DCVida), Regional University of the Northwest of the State of Rio Grande do Sul (UNIJUÍ), Ijuí, 98700-000, RS, Brazil


  • Online:2020-01-15 Published:2019-11-15


Background

Venous ulcer represents the most advanced stage of chronic venous insufficiency. It is an important public health problem and has a significant impact on patients’ quality of life due to chronic pain, inability to work, need for hospitalization and frequent outpatient follow-up.


Objective

We investigated the treatment benefits of far-infrared ceramic (cFIR), in a 90-day study of lower limb venous ulcers and looked atulcer healing scores, quality of life, serum bio-markers of oxidative stress and antioxidant defense enzymes.


Design, setting, participants and interventions

This is a randomized double-blind placebo-controlled study conducted in the Vascular Surgery Service of a hospital located in the northwest region of the State of Rio Grande do Sul, Brazil. We included patients with lower limb venous ulcers who were randomized to use either a bioceramics wrap or a placebo wrap for 90 days.


Main outcome measures

The following evaluations were conducted at baseline and after 15, 30, 60 and 90 days: ulcer healing score, quality of life, and serum markers of oxidative stress and antioxidant enzyme activity.


Results

Patients (n = 24) with lower limb venous ulcers were randomized into two treatment groups. cFIR decreased the ulcer size on day 30 (P = 0.042) and 90 (P = 0.034) and the total ulcer healing scale scores on day 30 (P = 0.049) and 90 (P = 0.02) of the treatment, when compared to baseline. Additionally, cFIR improved tissue type (epithelial tissue) on day 60 (= 0.022) when compared to baseline evaluation.


Conclusion

cFIR clinically improved ulcer healing in patients with lower limb venous ulcers.


Trial registration

RBR-8c7xzn on ReBEC.


Key words: Far-infrared radiation, Quality of life, Oxidative stress, Wound healing, Randomized controlled trial,  Bioceramic wrap

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