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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (2): 138-141.doi: 10.3736/jcim20030216

Special Issue: Traditional Chinese Medicine

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Studies on treatment of fatty liver with traditional Chinese medicine

Lie-ming Xu,Yi-yang Hu   

  1. Institute of Liver Diseases,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China
  • Received:2003-05-12 Online:2003-06-20 Published:2018-10-19

Great progress has been made in the study of fatty liver with integrated traditional Chinese and western medicine in aspects of diagnosis, treatment and experimental study, etc. Most researches were designed to utilize diagnostic or model replicating method of western medicine to observe the effects or investigate the action mechanism of compound recipe, single Chinese herb or effective ingredients of Chinese herbs on fatty liver. According to the pathological mechanism of traditional Chinese medicine (TCM), fatty liver is characterized by deficiency in nature and repletion in appearance, which involves three Zang viscera such as liver, spleen and kidney and manifests as spleen Qi deficiency, liver and kidney deficiency, phlegm and dampness heaping internally, and Qi stagnation and blood stasis. This facilitates us to use specific recipe or modified recipe to treat fatty liver from the points of integrated traditional Chinese and western medicine and combining syndrome differentiation with disease differentiation. With gratifying achievement, this kind of approach has been the mainstream of the research on fatty liver and many researchers have reached an agreement on this point domestically. Spleen Fortifying and Blood Invigorating Recipe (SFBVER in brief, invented by our institute) can significantly improve the B ultrasound outcome of the liver in patients with fatty liver, with significant difference in B ultrasound scoring between pre-and post-treatment. It can alleviate the patients' symptoms, improve or regain liver function, decrease waist/buttocks ratio and the content of triglyceride and cholesterol in blood. SFBVER is superior to Dongbao Gantai Recipe in general effective rate. Experimental study also reveals that SFBVER can alleviate CCl4 induced liver cell fatty degeneration and the inflammatory cell infiltration in rats, decrease the activities of ALT and AST, lower the content of triglyceride in liver, recover SOD activity in liver to normal level. The overall efficacy of SFBVER is superior to that of Dongbao Gantai Recipe. Further correlated study should be focused on inventing new preparation of traditional Chinese medicine and investigating its action mechanism with the guiding of the theory of TCM and referring to the latest discovery in fatty liver research in modern medicine.

Key words: fatty liver, integrated traditional Chinese and western medicine, therapy

CLC Number: 

  • R575
[1] 何东仪, 胡义扬, 薛惠明 , 等. 健脾活血方治疗脂肪肝的临床疗效观察[J]. 中国中西医结合消化杂志, 2001,9(1):35-37
doi: 10.3969/j.issn.1671-038X.2001.01.013
[2] 谭行华, 谭俊, 尹炽标 , 等. 抗脂益肝汤治疗脂肪肝31例[J]. 中西医结合肝病杂志, 2001,11(2):110-111
doi: 10.3969/j.issn.1005-0264.2001.02.031
[3] 祝峻峰, 李卫山 . 消脂汤治疗脂肪肝68例[J]. 中西医结合肝病杂志, 2001,11(2):109
doi: 10.3969/j.issn.1005-0264.2001.02.029
[4] 吴国潘 . 疏肝健脾法治疗脂肪肝疗效分析[J]. 江西中医药, 2001,32(6):24
[5] 李洁, 许佳年, 张琴 . 针药结合治疗脂肪肝32例临床观察[J]. 湖南中医药导报, 1999,5(6):17-18
[6] 何东仪, 胡义扬, 刘平 , 等. 健脾活血方对CCl4高脂低蛋白诱导的大鼠肝脂肪变性的影响[J]. 中国中医药科技, 2001,8(1):13-14
[7] 刘英宏, 姜南, 艾民 , 等. 脂肝消胶囊治疗脂肪肝的实验研究[J]. 中国中医药科技, 2000,7(4):269
[8] 杨冬娣, 黄真炎, 雷娓娓 , 等. 虎金丸对大鼠脂肪肝超微结构变化的影响[J]. 中医药研究, 2001,17(5):43-44
[9] 沈薇 . 非酒精性脂肪性肝病的药物治疗[J]. 中华肝脏病杂志, 2003,11(2):114
doi: 10.3760/j.issn:1007-3418.2003.02.018
[10] 殷国健, 朱向前, 徐力 . 中西医结合治疗高脂血症脂肪肝疗效观察[J]. 实用中西医结合杂志, 1994,7(2):104-105
[11] 胡义扬, 刘平, 刘成 , 等. 丹参提取物对CCl4和DMN诱导的大鼠肝纤维化的影响[J]. 上海中医药杂志, 1999,33(10):7-10
[12] 何熹延 . 泽泻与高脂血症、动脉硬化和脂肪肝[J]. 中国中西医结合杂志, 1981,1(2):114-117
[13] 钟毛英, 曹长恩, 刘德洪 , 等. 大黄蟅虫丸的药理研究与应用进展[J]. 中医药信息, 1998,15(2):10-12
[14] 翁维良 . 降血脂中草药研究进展[J]. 天津中医, 1986,3(1):34-38
[15] 苏玮, 郭群 . 何首乌的现代药理研究概况[J]. 中草药, 1997,28(2):119-121
doi: 10.7501/j.issn.0253-2670.1997.2.059
[16] 沈映君 . 中药药理学(第1版)[M]. 上海: 上海科学技术出版社, 1997,( 第1版):174
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[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
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