Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (11): 1096-1099.doi: 10.3736/jcim20091115

• Global Views • Previous Articles     Next Articles

Ayurvedic medicines in treatment of cancer

Sunyana Jaina,Vikrant Gillb,Neeru Vasudevac,Neelam Singlaa   

  1. a Department of Pharmacy, Advance Institute of Technology, Dehli-Mathura Road, Dist. Palwal 121102,Haryana, India
    b Ranbaxy Laboratories Ltd, Clinical Pharmacology and Pharmacokinetic Department, Gurgaon 122001, Haryana, India
    c Department of Pharmaceutical Sciences,Guru Jambheshwar University of Science and Technology, Hissar 125001, Haryana, India
  • Received:2009-07-09 Accepted:2009-08-27 Online:2009-11-20 Published:2009-11-15
  • Contact: Sunyana Jain E-mail:sunyanajain@rediffmail.com
  • Supported by:
    Paste of Capparis spinosa, Capparis sepiari, Agati grandiflora and Lagenaria vulgaris is applied locally for treatment of Kapaja granthi [25].;Paste of Glycyrrhiza glabra, Eugenia jambolana, Terminalia arjuna and Calamus rotang isapplied externally for the treatment of Paittika granthi [25].;This drug is prescribed in treatment of granthi [12].;Mixture of Helloborus niger, Tinospora cordifolia, Clerodendron serratum, Aegle marmelos, Hoya viridiflora and Elephantopus scber is applied locally for the treatment of vatika granthi [25].

Key words: Medicine, Ayurvedic, Neoplasma, Phytotherapy

"

No. Name of herb Method and use Common name
1 Allium sativum Linn.
(Liliaceae)
Solid extract is given and oil is applied on infected area. Water soluble compounds present are mainly responsible for anticancer activity. Useful in human breast, colon and prostrate cancers[15]. Lahsun
2 Abrus precatorius Linn.
(Fabaceae)
Leaf decoction and root powder are applied. It is useful for the treatment of Yoshida sarcoma, fibrosarcoma and ascites tumor cells[16]. Indian liquorice
3 Alstonia scholaris R. Brown.
(Apocyanaceae)
Leaf extract is given. It is useful in the treatment of HIS human sarcoma and benzopyrene-induced stomach carcinoma[17]. Chatiun
4 Asparagus racemosus Willd.
(Liliaceae)
Powder is given and is used in treatment of human epidermoid
carcinoma[18].
Shatavari
5 Andrographis paniculata Nees.
(Acanthaceae)
Powder or juice of leaf or stem is given and useful in treatment of various cancers[19]. Kalmegh
6 Amorphopallus campanulatus
Roxb. (Araceae)
The mature tuber is first burnt and then mixed with butter and jaggary and applied externally for tumour destruction[20]. Konyaku
7 Berberis aristata DC.
(Berberidaceae)
Powder is given and useful in the treatment of human epidermal carci-noma of the nasopharynx and N-nitrosodiethlyamine-induced carcinogenesis[21]. Chitra
8 Barleria prionitis Linn.
(Acanthaceae)
The oil prepared with whole plant is applied externally during acute
stages of cysts in blood vessels[22].
9 Basella rubra Linn.
(Chenopodiaceae)
The leaves are ground with sour buttermilk. Add some salt and indicated for Abruda[23]. Pothi, Valchibhagi
10 Baliospermum montanumWilld.
(Euphorbiaceae)
The paste consisting of Baliospermum montanum, Plumbago zeylanica, Euphorbia neriifolia, Calotropis procera, Semecarpus anacardium and jaggery applied to tumors[12]. Jamalgota
11 Boswellia serrata Roxb.
(Burseraceae)
Bark decoction, gum resins are given internally and oil is applied externally on tumor. It is useful in the treatment of human epidermal carci-noma of nasophyranx, leukemia and brain tumors[18, 24]. Kundur
12 Curcuma domestica Val.
(Zingiberaceae)
The Curcuma domestica powder in combination with Symplocos racemosa and Soymida febrifuga are mixed with honey and used exter-nally[12, 20]. Haladi
13 Capparis spinosa Linn.
(Caparidaceae)
Paste of Capparis spinosa, Capparis sepiari, Agati grandiflora and Lagenaria vulgaris is applied locally for treatment of Kapaja granthi[25]. Ber
14 Euphoria hirta Linn.
(Euphorbiaceae)
Powder and liquid extracts are given. Used to cure Freund virus leuke-mia[26]. Nahanidudheli
15 Eugenia jambolana Lamk. (Myrtaceae) Paste of Glycyrrhiza glabra, Eugenia jambolana, Terminalia arjuna and Calamus rotang isapplied externally for the treatment of Paittika granthi[25]. Jamun
16 Elephantopus scaber Linn.
(Compositae)
Fine paste of leaves of Ficus glomerata, Tectona grandis and Elephantopus scaber mixed with honey is applied locally for treatment of pittaja arbuda[25]. Gobhi
17 Ficus bengalensis Linn.
(Urticaceae)
Ficus bengalensis and Sausserea lappa mixture is applied to decrease tumor growth on bones[26]. Phagwari
18 Flacourtia romantchi L’ Her.
(Flacourtiaceae)
The paste of Flacourtia romantchi, Cassia fistula and Capparis sepiaria is recommended for kaphaja tumours[12]. Bhanber
19 Hygrophila spinosa Linn.
(Acanthaceae)
Seed powder and liquid extract are given to cure Daltons lymphoma and Ehrich ascites carcinoma of the nasophyranx[27, 28].
20 Madhuca indica Gmel.
(Sapotaceae)
The paste is prepared from bark of Madhuca indica, Syzygium cumini and Salix caperaand prescribed for local application[12].
21 Moringa oleifera Lam.
(Moringaceae)
The paste of Moringa olifera seeds, Solanum xanthocarpum, Sinapis dichotoma, Holarrhena antidysentrica and Nerium odorum roots prepared with butter milk is used for arbudatumors[29, 30]. Mungna
22 Oxoxylum indicum Linn.
(Bignoniaceae)
This drug is prescribed in treatment of granthi[12]. Podaval, Tetu
23 Proscopis cineraria Linn.
(Mimosaceae)
The paste made of Proscopis cineraria seeds, Raphanus sativa, Moringa oleifera, barley and mustard with buttermilk are applied locally to disintegrate cysts[22]. Chhikura
24 Pandanus odoratissimum Lem.
(Pandanaceae)
A paste of Pandanus odoratissimum and sugar are applied externally on tumors[12]. Kewoda.
25 Pterospermum acerifolium
Willd. (Sterculiaceae)
The flowers of Pterospermum acerifolium are mixed with sugar and applied externally[22]. Kanakchamka
26 Phyllanthus niruri Linn.
(Euphorbiaceae)
Aqueous extract of Phyllanthus niruri is applied locally for the treatment of cancer[25]. Buinowala.
27 Raphanus sativus Linn.
(Brassicaceae)
Local application of Raphanus sativus paste with radish ash is effective in Kaphaja arbuda[22] Black radish
28 Ricinus communis Linn.
(Euphorbiaceae)
Paste of Ricinus communis, Benincase cerifera, Cucumis memordica, Cocus nucifera and Eranda beeja along with buttermilk or milk is applied externally for the treatment of Vataja arbuda[31]. Castor oil
29 Tinospora cordifolia Miers.
(Menispermaceae)
Mixture of Helloborus niger, Tinospora cordifolia, Clerodendron serratum, Aegle marmelos, Hoya viridiflora and Elephantopus scber is applied locally for the treatment of vatika granthi[25]. Gulvel
30 Terminalia arjuna W & Arn.
(Combretaceae)
Bark powder is effective in kappha and pita[20]. Arjun
31 Vitis vinifera Linn.
(Vitaceae)
The mixture of Terminalia chebula, grape juice and sugarcane juice is used for the treatment of cancer[32]. Vine
32 Zingiber officinalis Rosc.
(Zingiberaceae)
Rhizome powder is given to cure cancer. Pungent principles present are responsible for anticancer activity[22]. Sunth
[1] Reddy L, Odhav B, Bhoola KD . Natural products for cancer prevention: a global perspective[J]. Pharmacol Ther, 2003,99(1):1-13
doi: 10.1016/S0163-7258(03)00042-1 pmid: 12804695
[2] Hartwell L . Plants used against cancer. A survey[J]. Lloydia, 1971,32(1):78-107
doi: 10.1016/0024-3205(69)90192-1 pmid: 5788771
[3] Srivastava V, Negi AS, Kumar JK, Gupta MM, Khanuja SP . Plant-based anticancer molecules: a chemical and biological profile of some important leads[J]. Bioorg Med Chem, 2005,13(21):5892-5908
doi: 10.1016/j.bmc.2005.05.066 pmid: 16129603
[4] Boik J. Conducting research on natural agents. In: Boik J. Cancer and natural medicine: A textbook of basic science and clinical research. Minnesota: Oregon Medical Press. 1996: 176-187.
[5] Farnsworth NR, Akerele O, Bingel AS, Soejarto DD, Guo Z . Medicinal plants in therapy[J]. Bull World Health Organ, 1985,63(6):965-981
[6] Cragg GM, Newman DJ, Snader KM . Natural products in drug discovery and development[J]. J Nat Prod, 1997,60(1):52-60
doi: 10.1021/np9604893
[7] Sastry JLN . Introduction to oncology(cancer) in Ayurveda[M]. Varanasi: Chaukhambha Orientalia, 2001: 1
[8] Balachandran P, Govindarajan R . Cancer an Ayurvedic perspective[J]. Pharmacol Res, 2005,51(1):19-30
doi: 10.1016/j.phrs.2004.04.010 pmid: 15519531
[9] Pandey G . Anticancer herbal drugs of India: with special reference to Ayurveda[M]. New Delhi: Sri Satguru Publications, 2002: 18-121
[10] Treadway S . An Ayurvedic herbal approach to a healthy liver[J]. Clin Nutr Insights, 1998,6(16):1-3
[11] Sharma PV . Caraka samhita. Including critical notes(Vol 1-4)[M]. Varanasi: Chaukhambha Orientalia, 1981,( Vol 1-4):544
[12] Bhishagratna KL.Sushruta Samhita , English translation, Nidana-sthana, Sarira-sthana, Chikitsa-sthana and Kalpa-sthana(Vol 2)[M]. Varanasi: Chowkhamba Sanskrit Series Office, 1991,( Vol 2):571
[13] Acharaya PK.Encyclopedia of Hindu architecture[M].New Dehli: Oriental Book Reprints Co, 1979:
[14] Badmaev V, Majeed M . Effects of Ayurvedic herbs. Health Supplement Retailer Magazine. 1995: 22-25.
[15] Hu X, Cao BN, Hu G, He J, Yang DQ, Wan YS . Attenuation of cell migration and induction of cell death by aged garlic extract in rat sarcoma cells[J]. Int J Mol Med, 2002,9(6):641-643
[16] Subba Reddy VV, Sirsi M . Effect of Abrus precatorius Linn. on experimental tumours[J]. Cancer Res, 1969,29(7):1447-1451
doi: 10.1002/1097-0142(196906)23:6<1436::AID-CNCR2820230627>3.0.CO;2-6 pmid: 5799161
[17] Jagetia GC, Baliga MS, Venkatesh P . Effect of Sapthaparna(Alstonia scholaris Linn) in modulating the benzo(a)pyrene-induced forestomach carcinogenesis in mice[J]. Toxicol Lett, 2003,144(2):183-193
doi: 10.1016/S0378-4274(03)00205-4
[18] Dhar ML, Dhar MM, Dhawan BN, Mehrotra B, Ray C . Screening of Indian plants for biological activity[J]. Indian J Exp Biol, 1968,( 6):232
[19] Trivedi NP, Rawal UM . Hepatoprotective and antioxidant property of Andrographis paniculata(Nees) in BHC-induced liver damage in mice[J]. Indian J Exp Biol, 2001,39(1):41-46
[20] Prasad GC . Studies on cancer in Ayurveda and its management[J]. J Res Ayur Sid, 1987,3(4):146-167
[21] Anis KV, Rajeshkumar NV, Kuttan R . Inhibition of chemical carcinogenesis by berberine in rats and mice[J]. J Pharm Pharmacol, 2001,53(5):763-768
doi: 10.1211/0022357011775901 pmid: 11370717
[22] Kinjavadekara RS. Astanga sangraha[M]. New Delhi: Uppal Publishing House,1998:
[23] Singh RH . An assessment of Ayurvedic concept of cancer and a new paradigm of anticancer treatment in Ayurveda[J]. J Altern Complemen Med, 2002,8(5):609-614
doi: 10.1089/107555302320825129
[24] Hostanska K, Daum G, Saller R . Cytostatic and apoptosis-inducing activity of boswellic acids toward malignant cell lines in vitro[J]. Anticancer Res, 2002,22(5):2853-2862
[25] 25Dash B, Kashyap L . Diagnosis and treatment of galaganda, gandamala, apaci, granthi and arbuda. In: Dash B, Kashyap L. Diagnosis and treatment of diseases in Ayurveda. New Delhi: Concept Publishing Company. 1987: 437.
[26] Murthy KRS.Bhavaprakasa of bhavamisra, Madhya and Uttara Khanda[M].Varanasi: Krishnadas Academy , 2001: Vol II
[27] Maiti B . Antineoplastic effects of the root extract of Hygrophila spinosa. Calcutta: Proceedings of the International Conference on Current Progress in Medicinal and Aromatic Plant Research. 1994: 135-140.
[28] Mazumdar UK, Gupta M, Maiti S, Mukherjee D . Antitumour activity of Hygrophila spinosa on Ehrlich ascites carcinoma and sarcoma-180 induced mice[J]. Indian J Exp Biol, 1997,35(5):473-477
[29] Dhawan BN, Dubey MP, Mehrotra BN, Rastogi RP, Tandon JS . Screening of Indian plants for biological activity: part Ⅸ.[J]. Indian J Exp Biol, 1980,18(6):594-606
doi: 10.1016/0019-2791(71)90395-8 pmid: 914326
[30] Bharali R, Tabassum J, Azad MR . Chemomodulatory effect of Moringa oleifera Lam. on hepatic carcinogen metabolising enzymes, antioxidant parameters and skin papillomagenesis in mice[J]. Asian Pac J Cancer Prev, 2003,4(2):131-139
[31] 31Singhal GD, Singh LM . The management of glandular swellings, cervical lymphadenopathy, tumours and goiters. In: Singhal GD, Singh LM. Operative considerations in ancient Indian surgery based on Susruta Samhita, Cikitsa sthana. Varanasi: Singhal Publications. 1982: 339-356.
[32] Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM . Cancer chemopreventive activity of resveratrol, a natural product derived from Grapes[J]. Science, 1997,275(5297):218-220
doi: 10.1126/science.275.5297.218 pmid: 8985016
[33] Office of Alternative Medicine.Office of alternative medicine workshop on the collection of clinical research data relevant to alternative medicine and cancer[M].Bethesda: Office of Alternative Medicine, 1994:
[1] Tara Rajendran. Addressing the need for personalizing music therapy in integrative oncology. Journal of Integrative Medicine, 2022, 20(4): 281-283.
[2] Wan-jun Guo, Yi Wang, Yu Deng, Lin-yan Cheng, Xin Liu, Ruo-fan Xi, Sheng-jie Zhu, Xin-yi Feng, Liang Hua, Kan Ze, Jian-yong Zhu, Dong-jie Guo, Fu-lun Li. Therapeutic effects of the extract of Sancao Formula, a Chinese herbal compound, on imiquimod-induced psoriasis via cysteine-rich protein 61. Journal of Integrative Medicine, 2022, 20(4): 376-384.
[3] Cai-lian Fana, Wan-jun Caib, Meng-nan Ye, Miao Chen, Yi Dai. Qili Qiangxin, a compound herbal medicine formula, alleviates hypoxia-reoxygenation-induced apoptotic and autophagic cell death via suppression of ROS/AMPK/mTOR pathway in vitro. Journal of Integrative Medicine, 2022, 20(4): 365-375.
[4] Shang-jin Song, Xuan Liu, Qing Ji, Da-zhi Sun, Li-juan Xiu, Jing-yu Xu, Xiao-qiang Yue. Ziyin Huatan Recipe, a Chinese herbal compound, inhibits migration and invasion of gastric cancer by upregulating RUNX3 expression. Journal of Integrative Medicine, 2022, 20(4): 355-364.
[5] Vibha Malhotra, Joanna Harnett, Erica McIntyre, Amie Steel, Keith Wong, Bandana Saini. To “tell or not to tell”—Exploring disclosure about medicine use by people living with sleep disorders. Journal of Integrative Medicine, 2022, 20(4): 338-347.
[6] Maryam Azimi, Hanieh Niayesh, Mahboobeh Raeiszadeh, Sedigheh Khodabandeh-shahraki. Efficacy of the herbal formula of Foeniculum vulgare and Rosa damascena on elderly patients with functional constipation: A double-blind randomized controlled tria. Journal of Integrative Medicine, 2022, 20(3): 230-236.
[7] Marisa Casal. Improving the health and treatment success rates of in vitro fertilization patients with traditional chinese medicine: need for more robust evidence and innovative approaches. Journal of Integrative Medicine, 2022, 20(3): 187-192.
[8] Ning Guo, Fei Wu, Mei Wu, Yuan Wang, Qing Lang, Xiao Lin, Yi Feng. Progress in the design and quality control of placeboes for clinical trials of traditional Chinese medicine . Journal of Integrative Medicine, 2022, 20(3): 204-212.
[9] Tareq A. Wani, Zahoor A. Kaloo, Nisar A. Dangroo. Aconitum heterophyllum Wall. ex Royle: A critically endangered medicinal herb with rich potential for use in medicine. Journal of Integrative Medicine, 2022, 20(2): 104-113.
[10] Mohammad Fazil, Sadia Nikhat. Why the “sugars” in traditional Unani formulations are a pivotal component: A viewpoint perspective. Journal of Integrative Medicine, 2022, 20(2): 91-95.
[11] Yan-jun Lin, Kun-li Jiao, Bo Liu, Lu Fang, Shu Meng. Antiplatelet and myocardial protective effect of shexiang tongxin dropping pill in patients undergoing percutaneous coronary intervention: A randomized controlled trial. Journal of Integrative Medicine, 2022, 20(2): 126-134.
[12] Deng-chao Wang, Miao Yu, Wen-xian Xie, Li-yan Huang, Jian Wei, Yue-hua Lei. Meta-analysis on the effect of combining Lianhua Qingwen with Western medicine to treat coronavirus disease 2019. Journal of Integrative Medicine, 2022, 20(1): 26-33.
[13] Mahlagha Dehghan, Alireza Ghanbari, Fatemeh Ghaedi Heidari, Parvin Mangalian, Mohammad Ali Zakerid. Use of complementary and alternative medicine in general population during COVID-19 outbreak: A survey in Iran. Journal of Integrative Medicine, 2022, 20(1): 45-51.
[14] Jose Antonio Castilla-Jimena, Isabel Ruiz-Pérez, Jesús Henares-Montiel. Impact of socioeconomic and health-related factors on consumption of homeopathic and natural remedies in Spain in 2006, 2011 and 2017. Journal of Integrative Medicine, 2022, 20(1): 52-56.
[15] Ofer Baranovitch, Meirav Wolff-Bar, Meora Feinmesser, Chen Sade-Zaltz, Ilan Tsarfaty, Victoria Neiman. Searching for the emotional roots of breast cancer: A cross-disciplinary analysis integrating psychology, Chinese medicine, and oncology biomarkers. Journal of Integrative Medicine, 2022, 20(1): 57-64.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228