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Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (3): 247-254.doi: 10.3736/jcim20070304

• Original Clinical Research • Previous Articles     Next Articles

Treatment of Alzheimer disease: an evidence-based review

Rong-fang Ji1, Jian-zhao Niu1, Shu-qiang Xu2, Jian Li1, Ji-feng Wang1, Jian-ping Liu3   

  1. 1. Laboratory of Cell and Biochemistry, Beijing University of Chinese Medicine, Beijing 100029, China 2. China-Japan Friendship Hospital, Beijing 100029, China 3. Evidence-Based Chinese Medicine Center for Clinical Research and Evaluation, Beijing University of Chinese Medicine, Beijing 100029, China
    2. Laboratory of Cell and Biochemistry, Beijing University of Chinese Medicine, Beijing 100029, China
    3. Laboratory of Cell and Biochemistry, Beijing University of Chinese Medicine, Beijing 100029, China 2. China-Japan Friendship Hospital, Beijing 100029, China 3. Evidence-Based Chinese Medicine Center for Clinical Research and Evaluation, Beijing University of Chinese Medicine, Beijing 100029, China
  • Online:2007-05-31 Published:2007-05-15

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Objective: The purpose of this research was mainly two-fold: first, to get an understanding of current researches conducted on Alzheimer disease in China; second, to systematically evaluate and compare Alzheimer's treatment delivered by traditional Chinese medicine (TCM) and Western medicine.

Methods: Two steps were employed in this research. They were data collection and cleaning, followed by systemic review and qualitative analysis. The data were selected from the following two databases: CNKI (http://www.cnki.net)and Wanfang Data (http://www.wanfangdata.com.cn). Inclusion criteria were: (1) Chinese literature; (2) Published between year 1994 and year 2004; (3) Using TCM as treatment and Western medicine as control; (4) Similar research purposes and methodology; (5) Subjects were diagnosed as Alzheimer disease. Descriptive analysis , homogeneity test, meta analysis, sensitivity analysis and subgroup analysis were performed in the second step.

Result: Supposing all qualified studies were of high quality, we got the following conclusion: the advantage of TCM was losing because of the newly-developed acetylcholinesterase inhibitors came in market. Moreover, the studies conducted after year 2002 were more homogeneous in comparison with those conducted in early years. Those studies using mini-mental status examination (MMSE ) as outcome measurement were also more homogeneous than non-MMSE measurement groups. Combined odds ratio in comparative studies was 1.5 fold higher than that in experimental studies. Regarding to different outcome measurement, those studies using TCM assessment profile were 2.58(4.79/1.86) fold higher than those using MMSE as outcome measurement.

Conclusions: After systemic literature search, we found that only 40 out of 2 403 studies met our inclusion criteria. Moreover, those qualified studies were of low quality. Therefore, the external validity of this study would be compromised. The solution to this would be to improve study quality by strengthening study design and carefully select more homogeneous subjects in terms of syndrome differentiation, by so doing, the results of meta analysis will be more convincing and easily recognized by international society.

Key words: evidence-based medicine, Alzheimer disease, data analysis, statistical, therapy, TCM

CLC Number: 

  • R749.16

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研究编号 来源 年龄(岁) 性別 试验药物 对照药物 治疗天数 指标 参考文献
序号
1 穆2004 60~89 男12;女23 聪脑汤 石杉碱甲 56 HDS-R 7
2 周2003 63~88 男62;女42 通窍益智汤 脑复康、尼莫地平 120 中医药学会 6
3 林2003 62~87 男26;女34 调心方 多奈哌齐 84 MMSE 8
4 林2003 62~87 男26;女34 补肾方 多奈哌齐 84 MMSE 8
5 林2003 62~87 男26;女34 调心方 多奈哌齐 84 ADL 8
6 林2003 62~87 男26;女34 补肾方 多奈哌齐 84 ADL 8
7 方2003 57~87 男26;女14 通郁汤 脑复康 缺 中医药学会 9
8 韩2002 缺 男41;女20 活血益智汤 脑复康、维生素C 56 中医药学会 4
9 董2002 55~82 男64;女36 益智健脑颗粒 脑复康 84 自拟 10
10 李2002 56~74 男32;女23 脑复益聪胶囊 脑复康 90 MMSE 11
11 李2002 56~74 男32;女23 脑复益聪胶囊 脑复康 90 ADL 11
12 李2002 56~74 男32;女23 脑复益聪胶囊 脑复康 90 中医药学会 11
13 高2001 59~86 男35;女25 脑复清胶囊 脑通 90 MMSE 12
14 袁2001 60~83 男155;女60 益肾健脑汤 谷维素、西比灵、γ-氨酪酸 42~56 中医药学会 5
15 刘2001 60~89 男12;女23 加味当归芍药散 石杉碱甲 56 HDS-R 13
16 杨2001 56~74 男116;女40 补肾健脑丸 维生素C 150~240 中医药学会 14
17 缪2000 54~85 男47;女39 党参、黄芪、何首乌、山萸肉、当归 胞二磷胆碱、脑复康 60 MMSE 15
18 张2000 65~79 男25;女20 益智防呆冲剂 脑复康 120 MQ 16
19 顾2000 52~91 男22;女26 养心健脑方 脑复康 90 HDS-R 17
20 顾2000 52~91 男22;女26 养心健脑方 脑复康 90 ADL 17
21 李2000 60~82 男21; 女34 调心方 他克林 84 MMSE 18
22 李2000 60~82 男21;女34 调心方 红糖水 缺 MMSE 18
23 李2000 60~82 男21;女34 调心方 他克林 缺 FOM 18
24 李2000 60~82 男21;女34 调心方 红糖水 缺 FOM 18
25 胡1999 50~80+ 男18;女12 补肾泻浊汤 维生素E 60~90 自拟积分法 19
26 王1998 60~86 男61;女29 地黄饮子加减 尼莫地平、脑复康 30 中医药学会 20
27 朱1998 57~88 男40;女26 自拟中药（疏肝解郁滋肾养心） 脑复康 90 中医药学会 21
28 肖1997 缺 男99;女30 益肾通络颗粒 脑复康 缺 中医药学会 22
29 吴1997 51~96 男116;女49 益智健身精 脑复康 60 中医药学会 23
30 王2001 60~89 男82;女28 左归饮加减 尼莫地平、康脑灵 缺 中医药学会 24
31 杨2001 58~82 男36;女2 黄芪注射液或肾气丸 脑复新 15 缺 25
32 李2001 60~78 男28;女20 醒脑液 脑复康 90 BSSD,CGI 26
33 王2002 60~78 男41;女19 七福饮加味 脑复康 60 中医药学会 27
34 孟2002 60~83 男59;女47 清脑方 胞二磷胆碱、脑复康 30 MMSE 28
35 门2002 49~75 男96;女52 海龙健脑胶囊 都可喜 60 中医药学会 29
36 李2002 60+ 男96;女52 加味补阳还五汤 脑复新 84 中医药学会 30
37 周2003 68±9.5 男20;女23 白虎汤加减 都可喜 60~120 MQ 31
38 周2003 68±9.5 男20;女23 白虎汤加减 都可喜 60~120 IQ 31
39 李2001 60~79 男43;女7 加味还少丹 喜得镇 60 中医药学会 32
40 卢1999 60~84 男14;女16 自拟中药（补肾填精化痰开窍） 吉洛特 60~120 缺 33

"

效应量指标 Cochran's Q 自由度 P值
Odds ratio 123.39 39 ＜0.000 1
Risk difference 281.82 39 ＜0.000 1

"

模型 比值比 95%可信区间 可信区间上下限之差
固定效应模型 3.289 3 2.732 5~3.959 6 1.227 1
随机效应模型 3.238 1 2.300 8~4.557 4 2.256 6

"

排除的研究 比值比 下限 上限
1 3.319 1 2.348 3 4.691 1
2 3.235 4 2.271 5 4.608 3
3 3.352 1 2.377 4 4.726 4
4 3.371 8 2.396 6 4.743 7
5 3.322 6 2.348 7 4.700 3
6 3.322 6 2.348 7 4.700 3
7 3.211 4 2.267 7 4.547 7
8 3.254 6 2.289 3 4.626 9
9 3.218 3 2.262 4.578 8
10 3.288 3 2.316 4 4.667 9
11 3.286 9 2.315 5 4.665 8
12 3.257 6 2.292 8 4.628 5
13 3.318 9 2.346 4.695 4
14 2.873 6 2.203 4 3.747 5
15 3.319 1 2.348 3 4.691 1
16 3.090 2 2.203 1 4.334 5
17 3.283 2.308 6 4.668 7
18 3.322 7 2.349 6 4.699
19 3.111 7 2.212 4 4.376 4
20 3.181 4 2.262 4.474 5
21 3.275 6 2.312 2 4.640 2
22 3.174 6 2.247 6 4.484
23 3.229 2 2.279 7 4.574 3
24 3.167 5 2.243 5 4.471 9
25 3.218 7 2.271 9 4.559 9
26 3.120 9 2.212 4 4.402 5
27 3.173 9 2.238 5 4.500 4
28 3.156 2 2.227 7 4.471 5
29 3.296 6 2.319 4.686 1
30 3.252 4 2.281 7 4.636
31 3.204 5 2.260 7 4.542 4
32 3.245 3 2.287 4.605 2
33 3.247 7 2.287 4 4.611 2
34 3.222 2.264 5 4.584 5
35 3.346 5 2.367 3 4.730 7
36 3.195 1 2.258 9 4.519 2
37 3.217 9 2.268 7 4.564 3
38 3.310 7 2.337 9 4.688 3
39 3.311 9 2.341 4 4.684 7
40 3.243 5 2.288 3 4.587 6

"

亚组分类标准 亚组 Cochran's Q 自由度 P
出版年份 2002年以前 83.880 4 21 0.000 0
2002年（含）以后 18.280 7 17 0.371 3
控制组 安慰剂 0.041 2 2 0.979 6
非神经传导介质类药物 36.394 5 22 0.050 2
神经传导介质类药物 3.528 2 7 0.832 2
混合多重用药 43.873 9 5 0.000 0
试验设计 试验性研究 67.923 1 31 0.000 0
比较性研究 49.798 2 7 0.000 0
疗效评定标准 迷你心智状态检查表 9.5 7 0.218 7
中医药学会 76.9 14 0.000 0

"

亚组分类标准 亚组 比值比 95%可信区间
出版年份 2002年以前 4.76 2.77~8.18
2002年（含）以后 2.11 1.59~2.78
控制组 安慰剂 12.41 6.16~24.98
非神经传导介质类药物 3.10 2.30~4.18
神经传导介质类药物 1.20 0.73~1.97
混合多重用药 7.00 1.21~40.45
试验设计 试验性研究 2.92 2.10~4.07
比较性研究 4.38 1.62~11.85
疗效评定标准 迷你心智状态检查表 1.86 1.12~3.09
中医药学会 4.79 2.57~8.98
[1] Sackett DL, Rosenberg WM, Gray JA , et al. Evidence based medicine: what it is and what it isn't. BMJ, 1996,312(7023):71-72
[2] Sackett DL, Richardson WS, Rosenberg W , et al. Evidence-based medicine: how to practice and teach EBM. New York: Churchill Livingstone, 1997: 1-11
doi: 10.1001/jama.284.18.2382
[3] Koppel R . Alzheimer's disease: the costs to U.S. businesses in 2002.Washington DC: Alzheimer's Association, 2002: 1-28
[4] 韩旭 . 活血益智汤治疗老年性痴呆临床观察. 湖北中医杂志, 2002,24(5):33
Han X.Treatment of Alzheimer's disease by Huoxue Yizhi Decoction: a clinical observation.Hubei Zhong Yi Za Zhi, 2002, 24(5):33. Chinese.
[5] 袁玉红 . 益肾健脑汤治疗老年性痴呆临床观察. 北京中医, 2001,( 4):25
Yuan YH.Treatment of Alzheimer's disease by Yishen Jiannao Decoction: a clinical observation.Beijing Zhong Yi, 2001,( 4):25. Chinese.
[6] 周健, 周马英, 许波良 . 通窍益智汤治疗老年期痴呆53例. 陕西中医, 2003,23(8):703-704
Zhou J, Zhou MY , Xu BL.Treatment of 53 patients with Alzheimers disease by TongqiaoYizhi Decoction.Shaanxi Zhong Yi, 2003, 23(8):703-704. Chinese.
[7] 穆俊霞, 李新毅 . 中药聪脑汤治疗老年性痴呆的临床研究. 山西中医学院学报, 2004,5(1):24-26
Mu JX , Li XY.Treatment of Alzheimer disease by Congnao Decoction: a clinical research.Shanxi Zhong Yi Xue Yuan Xue Bao, 2004, 5(1):24-26. Chinese.
[8] 林水淼, 王健, 周如倩 , 等. 从心、肾论治阿尔茨海默病的临床研究. 中国中西医结合杂志, 2003,23(8):24-27
Lin SM, Wang J, Zhou RQ , et al.Clinical study on treatment of Alzheimer's Disease from the viewpoint of Xin and Shen.Zhongguo Zhong Xi Yi Jie He Za Zhi, 2003, 23(8):24-27. Chinese with abstract in English
[9] 方鸿, 朱振铎 . 通郁汤治疗老年性痴呆的临床研究. 山西中医学院学报, 2003,4(3):27-28
Fang H , Zhu ZD.Treatment of Alzheimer disease by Tongyu Decoction: a clinical research.Shanxi Zhong Yi Xue Yuan Xue Bao, 2003, 4(3):27-28. Chinese
[10] 董克礼, 宋炜熙, 曾江正 . 益智健脑颗粒治疗阿尔茨海默氏病50例总结. 湖南中医杂志, 2002,18(3):13-14
Dong KL, Song WX , Zeng JZ.A summary of 50 cases of Alzheimer disease treated by Yizhi Jiannao Granule.Hunan Zhong Yi Za Zhi, 2002, 18(3):13-14. Chinese
[11] 李浩, 王承华, 王力 . 脑复益聪胶囊治疗老年性痴呆的临床观察. 中国中医药信息杂志, 2002,9(4):20-22
Li H, Wang CH , Wang L.Clinical observation of Alzheimer's disease treated with Naofu Yicong capsule.Zhongguo Zhong Yi Yao Xin Xi Za Zhi, 2002, 9(4):20-22. Chinese with abstract in English
[12] 高丹屏, 陈贵海, 杨军 . 脑复清胶囊治疗老年期痴呆30例临床观察. 中成药, 2001,23(4):31-33
[13] 刘孟渊, 王达平, 刘玉平 , 等. 加味当归芍药散治疗老年性痴呆的疗效观察. 广州中医药大学学报, 2001,18(1):31-34
[14] 杨晓, 谢东霞 . 补肾健脑丸治疗老年性痴呆92例. 山西中医, 2001,17(4):16-17
[15] 缪易, 葛朝辉, 李慧娟 , 等. 中医药治疗老年性痴呆症的临床研究. 南通医学院学报, 2000,20(4):354-355
Miao Y, Ge CH, Li HJ , et al.Clinical study of the traditional Chinese medicine on the treatment of Alzheimer's disease. Nantong Yi Xue Yuan Xue Bao, 2000, 2000,20(4):354-355 Chinese with abstract in English
[16] 张沁园, 丁向东, 王晓红 , 等. 益智防呆冲剂改善阿尔茨海默病记忆力的临床观察. 山东中医药大学学报, 2000,24(4):260-261
Zhang QY, Ding XD, Wang XH , et al.Improvement of memory impairment for patients with Alzheimer disease by using Yizhi Fangdai Granule: a clinical observation. Shandong Zhong Yi Yao Da Xue Xue Bao, 2000,24(4):260-261
[17] 顾耘, 林水淼, 刘仁人 , 等. 养心健脑方治疗阿尔茨海默病临床研究. 山东中医药大学学报, 2000,24(4):271-273
Gu Y, Lin SM, Liu RR , et al. Clinical study on heart and brain benefiting formula in treating Alzheimer's dementia. Shandong Zhong Yi Yao Da Xue Xue Bao, 2000,24(4):271-273
[18] 李亚明, 张春燕, 王健 , 等. 调心方对中、重度老年性痴呆病智力的影响. 现代康复, 2000,4(4):996-997
Li YM, Zhang CY, Wang J, et al.The effects of heart-benefiting recipe on the intellects of Alzheimer's disease patients whose state of illness were middle and serious.. Xian Dai Kang Fu 2000,4(4):996-997.Chinese with abstract in English
[19] 胡九东 . 补肾泻浊汤治疗老年性痴呆–附30例病例分析. 光明中医, 1999,14(82):39-41
[20] 王宏献 . 地黄饮子加减治疗老年性痴呆50例. 北京中医, 1998,( 1):13-14
[21] 朱振铎, 薛一涛, 霍青 , 等. 疏肝解郁、滋肾养心法治疗老年性痴呆34例临床研究. 山东中医药大学学报, 1998,22(5):346-348
[22] 肖森林, 蔡铁如, 李佑生 . 益肾通络颗粒剂治疗老年期痴呆129例. 湖南中医药导报, 1997,17(1):9-12
[23] 吴子明, 吴福华, 蒋俊和 , 等. 益智健身精治疗老年呆病临床观察. 湖南中医学院学报, 1997,17(1):9-12
[24] 王玉宇 . 左归饮加减治疗老年性痴呆60例. 海南医学, 2001,12(2):36-37
[25] 杨惠榕 . 老年性痴呆病的中医治疗体会. 国际医药卫生导报, 2001,( 4):32
[26] 李炳绪, 王彦英, 王福兰 , 等. 醒脑液治疗老年性痴呆28例. 中国行为医学科学, 2001,10(5):460
Li BX, Wang YY, Wang FL , et al. Treatment of 28 patients with Alzheimer disease by Xingnao Decoction. Zhongguo Xing Wei Yi Xue Ke Xue, 2001,10(5):460
[27] 王建明 . 七福饮加味治疗老年性痴呆32例. 辽宁中医杂志, 2002,29(1):43
[28] 孟宪忠, 张雅丽, 王集贤 , 等. 清脑方治疗老年性痴呆症56例临床观察. 中国中医药科技, 2002,9(2):120
Meng XZ, Zhang YL, Wang JX , et al.Treatment of 56 patients with Alzheimer disease by Qingnao Recipe: a clinical observation. Zhongguo Zhong Yi Yao Ke Ji, 2002,9(2):120
[29] 门艳丽, 曹金梅 . 海龙健脑胶囊治疗老年性痴呆148例. 中医研究, 2002,15(4):30-31
[30] 李新 . 加味补阳还五汤治疗老年性痴呆16例观察. 实用中医药杂志, 2002,18(11):9
[31] 周荣根 . 白虎汤加减治疗老年性痴呆23例. 陕西中医, 2003,23(8):700-701
[32] 李爱华 . 加味还少丹治疗老年性痴呆30例. 新中医, 2001,33(3):22
[33] 卢桂华 . 15例老年性痴呆的中药治疗. 浙江临床医学, 1999,1(4):245
[34] 傅仁杰 . 老年呆病的诊断、辨证分型及疗效评定标准. 中医杂志, 1991,32(1):56-58
[35] 张明园 . 精神病手册. 上海: 上海科学技术出版社,1999:439- 441, 434-435
[36] 牛建昭, 陈家旭 . 对异病同治内涵的思考. 中医药学报, 2003,31(4):1-2
Niu JZ, Chen J . Some insights from treating different diseases with the same method.Zhong Yi Yao Xue Bao, 2003, 2003,31(4):1-2 Chinese
[37] 李幼平.循证医学. 北京: 高等教育出版社, 2003 167
Li YP. Evidence-based medicine. Beijing: Higher Education Press,2003:167. Chinese
[38] 刘建平 . 中医药研究随机对照试验质量的现状及对策. 中国中西医结合杂志, 2003,23(1):62-64
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