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Journal of Chinese Integrative Medicine ›› 2004, Vol. 2 ›› Issue (6): 426-428.doi: 10.3736/jcim20040607

• Original Clinical Research • Previous Articles     Next Articles

Clinical effect of escin on patients with cutaneous pruritus caused by blood stasis and wind-dryness

Fu-lun Li(), Rong Xu, Rong Zhou, Bin Fan, Min Zhou, Wen-bin Xu, Di-qing Gu, Ming Zhang, Bin Li   

  1. Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
  • Received:2004-08-08 Online:2004-11-20 Published:2018-10-20

Objective: To observe the clinical effect of escin on patients with cutaneous pruritus caused by blood stasis and wind-dryness and to prove the theory that "wind should be treated by regulating blood disorder, and wind disappears after activating blood" in traditional Chinese medicine (TCM).Methods: Fifty-one patients were randomly divided into escin-treated group (n=30) and loratadine-treated group (n=21). The patients in the escin-treated group were treated with escin for 4 weeks (300 mg, b.i.d.), and the patients in the loratadine-treated group were treated with loratadine (10 mg, q.d.). Symptom score reducing index (SSRI) was used to assess the pruritus degree, lesion range and lesion shape before the treatment, 2 weeks and 4 weeks after the treatment, respectively.Results: Two weeks after the treatment, the effective rate of the escin-treated group was 63.3%, and the effective rate of the loratadine-treated group was 67.0%. Four weeks after the treatment, the effective rates were 86.7% and 80.0% in escin- and loratadine-treated groups respectively. There was no statistical difference in total scores of SSRI in two groups (P>0.05), and the scores of pruritus degree and lesion shape also had no statistical difference (P>0.05), while the score of lesion range of the escin-treated group was lower than that of the loratadine-treated group (P<0.05).Conclusion: Escin has satisfactory effect in treating pruritus caused by blood stasis and wind-dryness. The study confirms the TCM theory that "wind should be treated by regulating blood disorder, and wind disappears after activating blood".

Key words: escin, pruritus, activating blood to resolve stagnation

CLC Number: 

  • R758.31

Tab 1

Comparison of total scores between two groups ($\bar{x}$±s )"

Group Total SSRI score
Escin-treated group
Pretreatment 166.50±53.00
2 weeks after treatment 90.00±50.56
4 weeks after treatment 50.20±40.84*
Loratadine-treated group
Pretreatment 165.71±48.97
2 weeks after treatment 92.38±32.13
4 weeks after treatment 52.57±42.98*

Tab 2

Comparison of curative effects between two groups Cases (%)"

Group n Cured Significantly effective Improved Ineffective Total effective rate
Escin-treated group
2 weeks after treatment 30 1(3.3) 2(6.7) 16(53.3) 11(36.7) 19(63.3)
4 weeks after treatment 30 5(16.7) 10(33.3) 11(36.7) 4(13.3) 26(86.7)
Loratadine-treated group
2 weeks after treatment 21 1(4.8) 1(4.8) 12(57.2) 7(33.0) 15(67.0)
4 weeks after treatment 21 6(30.0) 3(15.0) 8(40.0) 4(20.0) 17(80.0)

Tab 3

Comparison of symptom scores between two groups ($\bar{x}$±s )"

Group n SSRI score
Pruritus degree Lesion range Lesion shape
Escin-treated group
Pretreatment 30 59.3±21.2 88.80±48.78 25.20±11.08
2 weeks after treatment 30 34.6±12.3 * 54.67±38.54 * 19.60±10.10
4 weeks after treatment 30 15.3±14.5 * 16.27±18.00 *△ 10.27±8.77*
Loratadine-treated group
Pretreatment 21 49.5±24.0 93.14±33.61 21.14±11.11
2 weeks after treatment 21 28.7±11.1 * 53.33±24.70 * 15.05±8.29
4 weeks after treatment 21 17.1±13.1 * 29.52±24.12 * 7.05±10.03 *
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