超微粉体技术对穿心莲药材中穿心莲内酯及脱水穿心莲内酯溶出率的影响

doi:10.3736/jcim20040618

Abstract

Objective: To investigate the effects of ultra-fine powder technique on dissolution rates of the components in Andrographis paniculata.Methods: High performance liquid chromatography was employed to determine the concentration of andrographolide and dehydroandrographolide in common powdered or ultra-fine powdered Andrographis paniculata.Results: The dissolution rates of andrographolide and dehydroandrographolide in ultra-fine powdered Andrographis paniculata were higher than those of the general powder.Conclusion: Ultra-fine powder technique promotes the dissolution rates of andrographolide and dehydroandrographolide.

Key words: Andrographis paniculata, ultra-fine powder technique, andrographolide

CLC Number:

R283

Rong-li Qiu, Lin Li, Xiang Li, Hai-xia Zhang, Jian-wei Chen. Effect of ultra-fine powder technique on dissolution rates of andrographolide and dehydroandrographolide in Andrographis paniculata. Journal of Chinese Integrative Medicine, 2004, 2(6): 456-458.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20040618

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[3]	陈德昌 . 穿心莲中穿心莲内酯、新穿心莲内酯和脱氧穿心莲内酯含量的薄层光密度测定法[J]. 药物分析杂志, 1986,6(4):232-234
[4]	杨建国, 吴韶铭 . HPLC法测定痢泻灵中穿心莲的含量[J]. 中成药, 1996,18(6):11-12
[5]	刘晔, 杨建云, 梁孟柏 . RP-HPLC法测定穿心莲中穿心莲内酯的含量[J]. 解放军药学学报, 2002,18(3):186-188 doi: 10.3969/j.issn.1008-9926.2002.03.021

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Sample	Andrographolide			Dehydroandrographolide
Sample	Peak aera	Average	RSD（%）	Peak aera	Average	RSD（%）
1	1858833	1880682	1.20	1289810	1280432	1.20
2	1879655			1298521
3	1876829			1282103
4	1898987			1273210
5	1857226			1254687
6	1912562			1284263

Sample	Andrographolide					Dehydroandrographolide
Sample	Added （mg）	Tested （mg）	Recovery （%）	Average （%）	RSD （%）	Added （mg）	Tested （mg）	Recovery （%）	Average （%）	RSD （%）
1	1.88	1.87	99.47	98.89	1.40	2.77	2.86	103.43	102.42	1.92
2	1.80	1.76	97.78			2.70	2.69	99.63
3	1.66	1.67	100.60			2.61	2.64	101.15
4	1.78	1.73	97.19			2.50	2.61	104.40
5	1.75	1.74	99.43			2.57	2.66	103.50

Sample	n	Content of andrographolide (%)	Content of dehydroandrographolide (%)
Ultra-fine powdered （5 μm）	3	14.6	12.9
Common powdered (120~130 μm)	3	3.5	4.1

Effect of ultra-fine powder technique on dissolution rates of andrographolide and dehydroandrographolide in Andrographis paniculata

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