三生化痰汤在非小细胞肺癌化疗中的应用

doi:10.3736/jcim20040208

Abstract

：Objective: To observe the clinical effect of Chinese medicine Sansheng Huatan Decoction combined with chemotherapy in treating advanced primary non-small-cell lung cancer and to evaluated the effect of Sansheng Huatan Decoction increasing clinical effect and decreasing toxicity in chemotherapy for non-small-cell lung cancer. Methods: One hundred and sixty patients of advanced primary non-small-cell lung cancer proved by pathological examination were randomized into two groups. The treatment group was treated with Sansheng Huatan Decoction and chemotherapy, and the control group was treated only with chemotherapy. The clinic effect, life quality, natural killer (NK) activities, liver and kidney functions, and blood routine test of the 2 groups were evaluated. Results: The clinical effective rates of the treatment and control groups were 56.7% and 48.2% respectively, and there was no statistic significance (P>0.10). The life quality, NK activities and blood routine test of the treatment group were better than those of the control group. Conclusion: Sansheng Huatan Decoction combined with chemotherapy is a better treatment for non small cell lung cancer as compared with chemotherapy.

Key words: Sansheng Huatan Decoction, non-small-cell lung cancer, integrated traditional Chinese with western medicine

CLC Number:

R734.2

Wei-ming Fang, Wei-ping Wang, Bing-wei Yan, Jian-yuan Zhou. Treatment of non-small-cell lung cancer with chemotherapy and Sansheng Huatan Decoction. Journal of Chinese Integrative Medicine, 2004, 2(2): 103-105.

/ / Recommend

Add to citation manager EndNote| Reference Manager|ProCite|BibTeX|RefWorks

URL: http://www.jcimjournal.com/EN/10.3736/jcim20040208

http://www.jcimjournal.com/EN/Y2004/V2/I2/103

TrendMD

Figures/Tables 3

Tab 1

Tab 2

Tab 3

References 4

[1]	上海市肿瘤研究所流行病学研究室.1999年上海市市区恶性肿瘤发病率[J].肿瘤,2002,5(3):259 doi: 10.3781/j.issn.1000-7431.2002.03.037
[2]	韩明权, 苏晋梅, 黄海茵, 等.序贯化放疗结合中药治疗54例晚期非小细胞肺癌患者的预后分析[J].中西医结合学报,2003,1(3):195-198
	Han MQ, Su JM, Huang HY, et al.Prognostic analysis of advanced non small cell lung cancer treated by sequential chemo-radiation therapy cimbined with tradtional Chinese medicine: A report of 54 cases[J].Zhong Xi Yi Jie He Xue Bao,2003,1(3):195-198
[3]	秦笃祥, 李道堂.临床胸部肿瘤学(第1版)[M].济南: 山东科学技术出版社,1995,(第1版):257-258
[4]	中华人民共和国卫生部医政司编.中国常见恶性肿瘤诊疗规范(第9分册)(第1版)[M].北京: 北京医科大学、中国协和医科大学联合出版社,1991,(第1版):10-13

Related Articles 8

[1]	Ming Zhang, Zhen-ye Xu, Bing Bai, Yun Dong. Feiyanning Decoction down-regulates the expressions of phosphorylated Akt and hypoxia inducible factor-1α proteins in transplanted lung adenocarcinoma in nude mice. Journal of Chinese Integrative Medicine, 2008, 6(6): 616-620.
[2]	Yu Hao, Ping Wang, Jun Wu, Quan-ying Qiu. Effects of ginsenoside and berberine on secretion of immunosuppressive cytokines in lung carcinoma cell line PG. Journal of Chinese Integrative Medicine, 2008, 6(3): 278-282.
[3]	Zhu-yi Zhang, Shi-qing Yu, Li-yun Miao, Xiao-ying Huang, Xiao-ping Zhang, Yu-ping Zhu, Xiao-hong Xia, Dan-qi Li. Artesunate combined with vinorelbine plus cisplatin in treatment of advanced non-small cell lung cancer: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(2): 134-138.
[4]	Mu-yun Zhu, Zheng-hua Jiang, Yuan-wen Lu, Yuan Guo, Jun-ji Gan. Matrine and anti-tumor drugs in inhibiting the growth of human lung cancer cell line. Journal of Chinese Integrative Medicine, 2008, 6(2): 163-165.
[5]	Kai-wen Hu, Fen Wang, Yang Cao, Xiu-lan He, Ming-huan Zuo, Wen-qiang Chen. Risk factors of traditional Chinese medical syndromes in moderate and advanced lung cancer patients with concurrent fungal pneumonia. Journal of Chinese Integrative Medicine, 2004, 2(5): 337-339.
[6]	Ming-quan Han, Jia-xiang Liu, Hong Gao, Shan-xiang Chen, Yan-wei Zhu, Ling Xu. Effects of Yifei Kangliu Oral Liquid on cell cycle and protein-nucleic acid synthesis of experimental lung cancer. Journal of Chinese Integrative Medicine, 2003, 1(3): 205-208.
[7]	Ming-quan Han, Jin-mei Su, Hai-yin Huang, Wei-hong Long, Li-ping Qin, Ping Qin, Wei Liu, Zhao-ying Sheng. Prognostic analysis of advanced non small cell lung cancer treated by sequential chemo-radiation therapy combined with traditional Chinese medicine: A report of 54 cases. Journal of Chinese Integrative Medicine, 2003, 1(3): 195-198.
[8]	Zhen-ye Xu. Evidence-based medicine and treatment of lung cancer. Journal of Chinese Integrative Medicine, 2003, 1(2): 151-154.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

Comments

Recommended 10

[1]	Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2]	Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3]	Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4]	Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5]	. Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6]	Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7]	Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8]	Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9]	Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10]	Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228

Group	Clinical stage	n	Complete remission	Partial remission	Stable disease	Progressive disease
Treatment group
	II	3	3( 2.9)	0	0	0
	IIIa	24	5( 4.8)	16(15.4)	2(1.9)	1(0.9)
	IIIb	33	5( 4.8)	19(18.2)	6(5.8)	3(2.9)
	IV	44	0	11(10.6)	28(26.9)	5(4.8)
	Total	104	13(12.5)	46(44.2)	36(34.6)	9(8.7)
Control group
	II	1	1(1.8)	0	0	0
	IIIa	14	3(5.3)	7(12.5)	3( 5.4)	1(1.8)
	IIIb	20	2(3.5)	9(16.2)	7(12.5)	2(3.5)
	IV	21	0	5(8.9)	13(23.2)	3(5.3)
	Total	56	6(10.6)	21(37.6)	23(41.2)	6(10.6)

Group	Gradation of toxicity	Leukocyte	Platelet	Hemoglobin
Treatment group（n=104）
	0	16(15.3)	20(19.2)	42(40.4)
	I	39(37.5)	32(30.8)	37(35.6)
	II	26(25.0)	48(46.2)	22(21.1)
	III	15(14.5)	2(1.9)	2(1.9)
	IV	8(7.7)	2(1.9)	1(1.0)
Control group（n=56）
	0	7(12.5)	16(28.5)	16(28.5)
	I	9(16.1)	14(25.0)	22(39.2)
	II	16(28.5)	16(28.6)	13(23.2)
	III	18(32.2)	9(16.1)	4(7.2)
	IV	6(10.7)	1(1.8)	1(1.8)

Group	n	TBIL（μmol/L）	ALT（U/L）	BUN（mmol/L）	Cr（μmol/L）
Treatment group
Before treatment	104	16.9±8.9	52.6±6.7	5.2±1.9	95±28
After treatment	104	15.4±7.6	51.7±10.5	5.4±2.3	104±34
Control group
Before treatment	56	15.9±6.9	51.9±23.3	5.3±1.7	89±36
After treatment	56	19.7±7.2	69.4±29.4	6.2±2.1	114±32

Treatment of non-small-cell lung cancer with chemotherapy and Sansheng Huatan Decoction

RichHTML

PDF (PC)

Like