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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (3): 195-198.doi: 10.3736/jcim20030315

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Prognostic analysis of advanced non small cell lung cancer treated by sequential chemo-radiation therapy combined with traditional Chinese medicine: A report of 54 cases

Ming-quan Han(), Jin-mei Su, Hai-yin Huang, Wei-hong Long, Li-ping Qin, Ping Qin, Wei Liu, Zhao-ying Sheng   

  1. Department of Integrated Traditional Chinese and Western Medicine,Pulmonary Disease Hospital of Shanghai, Shanghai 200433, China
  • Received:2003-07-21 Online:2003-09-20 Published:2003-09-20


To evaluate the influence of fewer courses and prolonged intervals of chemotherapy on survival rate of advanced non small cell lung cancer (NSCLC) patients treated by sequential chemo-radiation therapy combined with traditional Chinese medicine (TCM).


From Jan.2000 to Dec.2001, 54 untreated advanced NSCLC patients (2 stage Ⅲa, 18 stage Ⅲb, 34 stage Ⅳ) were treated by sequential chemo-radiation therapy combined with TCM. The courses of chemotherapy were reduced and the intervals of chemotherapy were longer than that of the standard regimen. The efficacy and survival rate were documented and the prognostic factors were analyzed.


Complete remission (CR) was observed in 1 case and partial remission (PR) in 20 cases. The overall objective response rate was 40.4%. Median survival was 15.3 months, 1-, 2- and 3- year survival rate were 53.7%, 28.9% and 9.6% respectively. The median survival of stage Ⅲ and Ⅳ were 21.8 months and 12.5 months respectively. The 1-, 2-, and 3- year survival rates of stage Ⅲ were 65.0%,49.5%, 24.7% and that of stage Ⅳ were 47.0%, 23.3%, 0%, respectively. The quality of life was improved in most of the patients. Cox's proportional hazards regression showed that improved quality of life and treatment of TCM were the significant prognostic factors of overall survival.


Chemotherapy and radiotherapy combined with TCM is beneficial to extending the interval of chemotherapy, improving the quality of life, and increasing the survival rate of advanced NSCLC patients.

Key words: advanced NSCLC, prognostic factor, survival time, quality of life, chemotherapy, radiotherapy, drugs, Chinese herbal

CLC Number: 

  • R734.2


患者类别 n 1年生存率(%) 2年生存率(%) 3年生存率(%) 中位生存期(月)
Ⅲ期 20 65.0 49.5 24.7 21.8
Ⅳ期 34 47.0 23.3 0 12.5
全部患者 54 53.7 28.9 9.6 15.3


变量 回归系数(β) 标准误(Sx P 相对危险度[Exp(β)]
性别 -0.458 0.371 0.217 0.632
年龄 0.554 0.317 0.080 1.740
病理类型 0.028 0.210 0.893 1.029
TNM分期 0.734 0.361 0.042 2.084
近期疗效 0.741 0.289 0.010 2.098
Karnofsky评分 -1.182 0.217 0.000 0.307
化疗疗程 -0.469 0.182 0.010 0.626
化疗间隔时间 -0.538 0.172 0.002 0.584
放疗 -0.407 0.277 0.142 0.666
中药治疗 -1.120 0.340 0.001 0.326


变量 回归系数(β) 标准误(Sx P 相对危险度[Exp(β)]
性别 -0.074 0.537 0.890 0.928
年龄 -0.038 0.483 0.938 0.963
病理类型 0.509 0.290 0.079 1.663
TNM分期 0.455 0.448 0.310 1.576
近期疗效 0.339 0.362 0.349 1.404
Karnofsky评分 -1.282 0.329 0.000 0.277
化疗疗程 -0.445 0.301 0.139 0.641
化疗间隔时间 -0.341 0.275 0.215 0.711
放疗 -0.231 0.387 0.550 0.794
中药治疗 -1.321 0.511 0.010 0.267
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