差异蛋白质组学技术在针刺机制研究中的应用

doi:10.3736/jcim20110802

Abstract

Proteomics, a new branch of science, has been used to study protein expressions on the molecular level with a dynamic perspective. Organisms under varying states may express different proteins, which results in the set-up of differential proteomics. Research methods of differential proteomics include the separation and identification of proteins. Differential proteomics has a rapid development in recent years. In the study of acupuncture, researchers have reached certain achievements using differential proteomics to investigate the mechanisms of acupuncture treatment for some diseases, including acute spinal cord injury, ischemic cerebrovascular disease, Parkinson’s disease and neuralgia.

Key words: proteomics, acupuncture, differential expression, review

Lin-na Yu, Jian Pei. Application of differential proteomics in mechanism research of acupuncture. Journal of Chinese Integrative Medicine, 2011, 9(8): 819-823.

/ / Recommend

Add to citation manager EndNote| Reference Manager|ProCite|BibTeX|RefWorks

URL: http://www.jcimjournal.com/EN/10.3736/jcim20110802

http://www.jcimjournal.com/EN/Y2011/V9/I8/819

TrendMD

References 21

[1]	Lu DP, Lu GP, Lu PM . Clinical effectiveness of acupuncture for mandibular subluxation and dislocation[J]. Acupunct Electrother Res, 2010,35(3-4):187-192 doi: 10.3727/036012910803860896 pmid: 21319604
[2]	Huang W, Howie J, Taylor A, Robinson N . An investigation into the effectiveness of traditional Chinese acupuncture(TCA) for chronic stress in adults: a randomised controlled pilot study[J]. Complement Ther Clin Pract, 2011,17(1):16-21 doi: 10.1016/j.ctcp.2010.05.013
[3]	Pfab F, Winhard M, Nowak-Machen M, Napadow V, Irnich D, Pawlik M, Bein T, Hansen E . Acupuncture in critically ill patients improves delayed gastric emptying: a randomized controlled trial[J]. Anesth Analg, 2011,112(1):150-155 doi: 10.1213/ANE.0b013e3181fdfac8
[4]	Sung HJ, Kim YS, Kim IS, Jang SW, Kim YR, Na DS, Han KH, Hwang BG, Park DS, Ko J . Proteomic analysis of differential protein expression in neuropathic pain and electroacupuncture treatment models[J]. Proteomics, 2004,4(9):2805-2813 doi: 10.1002/(ISSN)1615-9861
[5]	Yang YQ, Chen HP, Wang Y, Cui JM, Wang Y, Liu YY . Research on the substantial basis of acupuncture efficacy[J]. Shanghai Zhen Jiu Za Zhi, 2007,32(6):399-401
	杨永清, 陈汉平, 王宇, 崔建美, 王燕, 刘艳艳 . 针灸效应物质基础研究[J]. 上海针灸杂志, 2007,32(6):399-401
[6]	Fujii K, Nakano T, Kawamura T, Usui F, Bando Y, Wang R, Nishimura T . Multidimensional protein profiling technology and its application to human plasma proteome[J]. J Proteome Res, 2004,3(4):712-718 doi: 10.1021/pr030007q pmid: 15359723
[7]	Kim SY, Lee PY, Shin HJ, Kim DH, Kang S, Moon HB, Kang SW, Kim JM, Park SG, Park BC, Yu DY, Bae KH, Lee SC . Proteomic analysis of liver tissue from HBx-transgenic mice at early stages of hepatocarcinogenesis[J]. Proteomics, 2009,9(22):5056-5066 doi: 10.1002/pmic.v9:22
[8]	Li W, Li JF, Qu Y, Chen XH, Qin JM, Gu QL, Yan M, Zhu ZG, Liu BY . Comparative proteomics analysis of human gastric cancer[J]. World J Gastroenterol, 2008,14(37):5657-5664 doi: 10.3748/wjg.14.5657
[9]	Su M, Li LQ, Peng T, Guo Y, Xiao KY, Shang LM, Xu BH, Li SL, Su ZX, Ye XP . Comparative proteomic analysis of differentiating multicentric occurrence and intrahepatic metastasis in multinodular hepatocellular carcinoma[J]. Ai Zheng, 2010,29(1):52-58 doi: 10.3760/cma.j.issn.1007-8118.2007.02.018
	苏铭, 黎乐群, 彭涛, 郭雅, 肖开银, 尚丽明, 徐邦浩, 李仕来, 苏智雄, 叶新平 . 肝内转移与多中心发生多结节肝癌的比较蛋白质组学分析[J]. 癌症, 2010,29(1):52-58 doi: 10.3760/cma.j.issn.1007-8118.2007.02.018
[10]	Wang HL, Han J, Liu F, Zhao YQ, Li P, Wang J, Liu BY, Yang SC, Wei KH . Analysis of the primary structure of modified and unknown peptides by nanoelectrospray tandem mass spectrometry[J]. Fen Xi Ce Shi Xue Bao, 2007,26(s1):10-11, 14
	王鸿丽, 韩静, 刘锋, 赵永强, 李萍, 王杰, 刘炳玉, 杨松成, 魏开华 . 串联飞行时间质谱鉴定急性脊髓损伤大鼠针刺后的差异蛋白质[J]. 分析测试学报, 2007,26(s1):10-11, 14
[11]	Li ZG, Geng H, Yuan XC, Wei KH . Influence of GV electroacupuncture on different expressed proteins in rats with spinal cord injury in 6 hours[J]. Beijing Zhong Yi Yao Da Xue Xue Bao, 2008,31(3):202-205
	李志刚, 耿昊, 苑晓晨, 魏开华 . 督脉电针对急性脊髓损伤6 h后大鼠差异蛋白质组学的机理研究[J]. 北京中医药大学学报,2008,31(3):202-205
[12]	Yuan XC, Song JL, Tian GH, Shi SH, Li ZG . Proteome analysis on the mechanism of electroacupuncture in relieving acute spinal cord injury at different time courses in rats[J]. Zhen Ci Yan Jiu, 2009,34(2):75-82
	苑晓晨, 宋金玲, 田贵华, 时素华, 李志刚 . 不同时段电针对急性脊髓损伤大鼠作用机制的蛋白质组学分析[J]. 针刺研究,2009,34(2):75-82
[13]	Li W, Zhong GW, Wang SE, Li ZY, Tang HM, Deng GC, Liu YZ, Zhou LY, Yan YP, Li Z . Effects of acupuncture on proteome of pallium in rats with ischemic cerebrovascular disease[J]. Zhong Yi Yao Dao Bao, 2008,14(1):9-11
	李炜, 钟广伟, 王素娥, 李臻琰, 唐红梅, 邓干初, 刘远诊, 周凌燕, 颜永平, 李智 . 针刺对缺血性脑血管疾病大鼠脑皮质蛋白质差异表达的影响[J]. 中医药导报, 2008,14(1):9-11
[14]	Wang S, Wen JR, Zhao XF, Shi XM . Changes in protein level of basal ganglia in rats with focal cerebral ischemia after “Xingnao Kaiqiao” acupuncture[J]. Zhongguo Lin Chuang Kang Fu, 2006,10(31):87-89 doi: 10.3321/j.issn:1673-8225.2006.31.038
	王舒, 温景荣, 赵晓峰, 石学敏 . “醒脑开窍”针刺后局灶性脑缺血模型大鼠脑基底核组织在蛋白质水平上的变化[J]. 中国临床康复, 2006,10(31):87-89 doi: 10.3321/j.issn:1673-8225.2006.31.038
[15]	Wen JR, Zhao XF, Wang S, Shi XM . Effect of Xingnao Kaiqiao acupuncture on proteomics in hippocampus in rats with focal cerebral ischemia[J]. Tianjin Zhong Yi Yao, 2007,24(6):447-451
	温景荣, 赵晓峰, 王舒, 石学敏 . “醒脑开窍”针刺法对局灶性脑缺血大鼠海马蛋白质组学影响的研究[J]. 天津中医药, 2007,24(6):447-451
[16]	Wen JR, Zhao XF, Wang S, Shi XM . Effect of acupuncture and construction of differential expression map of hippocamp proteome in rats with focal cerebral ischemia[J]. Tianjin Zhong Yi Yao, 2008,25(2):96-99
	温景荣, 赵晓峰, 王舒, 石学敏 . 局灶性脑缺血大鼠海马蛋白质组差异表达图谱的构建及针刺影响[J]. 天津中医药, 2008,25(2):96-99
[17]	Jeon S, Kim YJ, Kim ST, Moon W, Chae Y, Kang M, Chung MY, Lee H, Hong MS, Chung JH, Joh TH, Lee H, Park HJ . Proteomic analysis of the neuroprotective mechanisms of acupuncture treatment in a Parkinson’s disease mouse model[J]. Proteomics, 2008,8(22):4822-4832 doi: 10.1002/pmic.v8:22
[18]	Sung HJ, Kim YS, Kim IS, Jang SW, Kim YR, Na DS, Han KH, Hwang BG, Park DS, Ko J . Proteomic analysis of differential protein expression in neuropathic pain and electroacupuncture treatment models[J]. Proteomics, 2004,4(9):2805-2813 doi: 10.1002/(ISSN)1615-9861
[19]	Tonge R, Shaw J, Middleton B, Rowlinson R, Rayner S, Young J, Pognan F, Hawkins E, Currie I, Davison M . Validation and development of fluorescence two-dimensional differential gel electrophoresis proteomics technology[J]. Proteomics, 2001,1(3):377-396 doi: 10.1002/(ISSN)1615-9861
[20]	Hou S, Hu LS, Chang M, Wu J, Zhang L, Li HJ . Proteomic research of early differentiation induced by NGF in PCI2 cells using DIGE system and MALDI-TOF MS[J]. Zhong Feng Yu Shen Jing Ji Bing Za Zhi, 2006,23(1):52-54 doi: 10.3969/j.issn.1003-2754.2006.01.016
	侯澍, 胡林森, 常明, 吴江, 张磊, 李红杰 . NGF诱导PC12细胞早期分化的DIGE分析[J]. 中风与神经疾病杂志, 2006,23(1):52-54 doi: 10.3969/j.issn.1003-2754.2006.01.016
[21]	Lee WL, Wen TN, Shiau JY, Shyur LF . Differential proteomic profiling identifies novel molecular targets of paclitaxel and phytoagent deoxyelephantopin against mammary adenocarcinoma cells[J]. J Proteome Res, 2010,9(1):237-253 doi: 10.1021/pr900543e

Related Articles 15

[1]	Chiung-Hui Huang, Mei-Ling Yeh, Fang-Pey Chen, Daphne Wu. Low-level laser acupuncture reduces postoperative pain and morphine consumption in older patients with total knee arthroplasty: A randomized placebo-controlled trial. Journal of Integrative Medicine, 2022, 20(4): 321-328.
[2]	Ming-min Xu, Pei Guo, Qing-yu Ma, Xuan Zhou, Yu-long Wei, Lu Wang, Yue Chen, Yu Guo. Can acupuncture enhance therapeutic effectiveness of antidepressants and reduce adverse drug reactions in patients with depression? A systematic review and meta-analysis. Journal of Integrative Medicine, 2022, 20(4): 305-320.
[3]	Yen-Lin Chao, Yi-Ai Rau, Hong-Sheng Shiue, Jiun-Lin Yan, Yuan-Yun Tang, Shao-Wen Yu, Bo-Yan Yeh, Yen-Lung Chen, Tsung-Hsien Yang, Shu-Chen Cheng, Yi-Wen Hsieh, Hsin-Chia Huang, Fu-Kuang Tsai, Yu-Sheng Chen, Geng-Hao Liu. Using a consensus acupoints regimen to explore the relationship between acupuncture sensation and lumbar spinal postoperative analgesia: A retrospective analysis of prospective clinical cooperation. Journal of Integrative Medicine, 2022, 20(4): 329-337.
[4]	Sergey Filist, Riad Taha Al-Kasasbeh, Olga Shatalova, Nikolay Korenevskiy, Ashraf Shaqadan, Zeinab Protasova, Maksim Ilyash, Mikhail Lukashov. Biotechnical system based on fuzzy logic prediction for surgical risk classification using analysis of current-voltage characteristics of acupuncture points. Journal of Integrative Medicine, 2022, 20(3): 252-264.
[5]	Ting-ting Lu, Cun-cun Lu, Mei-xuan Li, Li-xin Ke, Hui Cai, Ke-hu Yang. Reporting and methodological quality of meta-analyses of acupuncture for patients with migraine: A methodological investigation with evidence map. Journal of Integrative Medicine, 2022, 20(3): 213-220.
[6]	Xiang-yu Wei, Shi-lei Luo, HuiChen, Shan-shan Liu, Zhi-gang Gong, Song-huaZhan. Functional connectivity changes during migraine treatment with electroacupuncture at Shuaigu (GB8). Journal of Integrative Medicine, 2022, 20(3): 237-243.
[7]	Samwel Sylvester Msigwa, Yan Li, Xiang-lin Cheng, Fen Cao. Combining electroacupuncture and transcranial direct current stimulation as an adjuvant therapy enhances spontaneous conversation and naming in subacute vascular aphasia: A retrospective analysis. Journal of Integrative Medicine, 2022, 20(3): 244-251.
[8]	Witoo Dilokthornsakul, Ramanya Kosiyaporn, Rattanamanee Wuttipongwaragon, Piyameth Dilokthornsakul. Potential effects of propolis and honey in COVID-19 prevention and treatment: A systematic review of in silico and clinical studies. Journal of Integrative Medicine, 2022, 20(2): 114-125.
[9]	Xiao Ye, Yu-lan Ren, Yun-hui Chen, Ji Chen, Xiao-jiao Tang, Zong-ming Zhang. A "4D" systemic view on meridian essence: Substantial, functional, chronological and cultural attributes. Journal of Integrative Medicine, 2022, 20(2): 96-103.
[10]	Bin Zhao, Yong Chen, Shi-min Liao, Jian-ying Zheng, Shi-hua Yan, Dong-shu Zhang. Successfully treated recalcitrant atopic eczema with acupoint autohemotherapy: A case report and hypothesized mechanism of the therapy. Journal of Integrative Medicine, 2022, 20(2): 182-186.
[11]	Jun-peng Yao, Li-ping Chen, Xian-jun Xiao, Ting-hui Hou, Si-yuan Zhou, Ming-min Xu, Kai Wang, Yu-jun Hou, Lin Zhang, Ying Li. Effectiveness and safety of acupuncture for treating functional constipation: An overview of systematic reviews. Journal of Integrative Medicine, 2022, 20(1): 13-25.
[12]	Yi Yuan, Rui-Ting Wang, Jun Xia, Hui-Juan Cao. Interventions for preventing influenza: an overview of Cochrane systematic reviews and a Bayesian network meta-analysis. Journal of Integrative Medicine, 2021, 19(6): 503-514.
[13]	Xin Yin, Shu-bin Cai, Lan-ting Tao, Lu-ming Chen, Zhong-de Zhang, Su-hong Xiao, Arthur Yin Fan, Xu Zou. Recovery of a patient with severe COVID-19 by acupuncture and Chinese herbal medicine adjuvant to standard care. Journal of Integrative Medicine, 2021, 19(5): 460-466.
[14]	Thomas Efferth, An-long Xu, Roxana Damiescu, Mita Banerjee, Norbert W. Paul, David Y.W. Lee. Can eastern wisdom resolve western epidemics? Traditional chinese medicine therapies and the opioid crisis. Journal of Integrative Medicine, 2021, 19(4): 295-299.
[15]	Meng-zhu Zhao, Chen Zhao, Shuang-shuang Tu, Xu-xu Wei, Hong-cai Shang. Evaluating the methodology of studies conducted during the global COVID-19 pandemic: A systematic review of randomized controlled trials. Journal of Integrative Medicine, 2021, 19(4): 317-326.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

Comments

Recommended 10

[1]	Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[2]	Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76
[3]	Xi Lin, Jian-ping Liu. Herbal medicines for viral myocarditis. Journal of Chinese Integrative Medicine, 2008, 6(1): 76
[4]	Xi Lin, Jian-ping Liu. Tai chi for treating rheumatoid arthritis. Journal of Chinese Integrative Medicine, 2008, 6(1): 82
[5]	Liang-ping Hu, Hui Gao. Discrimination of errors in statistical analysis of medical papers published in the first issue of 2006 in Journal of Chinese Integrative Medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 98-106
[6]	Yan-bo Zhu , Qi Wang, Cheng-yu Wu, Guo-ming Pang, Jian-xiong Zhao, Shi-lin Shen, Zhong-yuan Xia , Xue Yan . Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. Journal of Chinese Integrative Medicine, 2010, 8(11): 1023-1035
[7]	Wei Xu, Meng Shi, Jian-gang Liu, Cheng-long Wang . Collagen protein expressions in ischemic myocardium of rats with acute myocardial infarction and effects of qi-tonifying, yin-tonifying and blood-activating herbs and detoxifying and blood-activating herbs. Journal of Chinese Integrative Medicine, 2010, 8(11): 1041-1047
[8]	Tao Wang , Feng Qin. Effects of Chinese herbal medicine Xiaoyao Powder on monoamine neurotransmitters in hippocampus of rats with postpartum depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1075-1079
[9]	Ying Xu , Chang-chun Zeng , Xiu-yu Cai , Rong-ping Guo , Guang Nie , Ying Jin. Chromaticity and optical spectrum colorimetry of the tongue color in different syndromes of primary hepatic carcinoma. Journal of Chinese Integrative Medicine, 2012, 10(11): 1263-1271
[10]	Xiang-ying Mao , Qin Bian , Zi-yin Shen. Analysis of the osteogenetic effects exerted on mesenchymal stem cell strain C3H10T1/2 by icariin via MAPK signaling pathway in vitro. Journal of Chinese Integrative Medicine, 2012, 10(11): 1272-1278

Application of differential proteomics in mechanism research of acupuncture

RichHTML

PDF (PC)

Like