针刺对干眼症患者泪液中乳铁蛋白及泪液分泌影响的随机对照试验

doi:10.3736/jcim20120909

Abstract

Background: With the understanding of the immune inflammatory response in the pathogenesis of dry eyes, and the limitations of widely used artificial tears and numerous pharmaceuticals and methods to promote tear secretion, clinicians pay more attention to the therapies that can promote tear secretion actively. Acupuncture treatment for dry eye may meet this requirement.

Objective: To observe the clinical efficacy of acupuncture treatment on dry eye and the effects on duration, and to examine the mechanisms of acupuncture in treating patients with dye eyes. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: The study was performed at Department of Ophthalmology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine from August 2010 to May 2011. Patients with the primary diagnosis of dry eye were enrolled. Sixty-five patients were randomly divided into treatment group and control group, and were given 3 weeks of acupuncture treatment or artificial tear therapy respectively. MAIN OUTCOME MEASURES: The enzyme-linked immunosorbent assay was used to detect the lactoferrin content of the tears before and after treatment. In order to evaluate the efficacy of the treatment methods, the Schirmer Ⅰ test and break-up time were also measured.

Results: Compared with before treatment, the lactoferrin content in the tears of patients in the treatment group increased, break-up time was prolonged and the result of the Schirmer Ⅰ test showed improvement after 3 weeks of treatment. The indexes mentioned above did not change in the control group after treatment. There were no significant differences in tear lactoferrin and Schirmer Ⅰ test between one week after treatment and after 3-week treatment in the treatment group, but break-up time was significantly shortened. The result of Schirmer I test in the treatment group was significantly higher than that in the control group one week after treatment.

Conclusion: Acupuncture can increase tear lactoferrin level, extend tear film break-up time and promote tear secretion in patients with dry eye in a time-limited trial. With the end of treatment, the effect decreased.

Key words: dry eye, lactoferrin, acupuncture, randomized controlled trial

Jing-lin Shi, Wan-hong Miao. Effects of acupuncture on lactoferrin content in tears and tear secretion in patients suffering from dry eyes: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(9): 1003-1008.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20120909

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References 20

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Group	n	Tear lactoferrin
Group	n	Before treatment	After 1 course of treatment	One week after treatment
Control	34	1.44±0.27	1.49±0.30	1.52±0.32
Treatment	31	1.55±0.34	1.72±0.32^*▲▲	1.62±0.32

Group	n	Break-up time
Group	n	Before treatment	After 1 course of treatment	One week after treatment
Control	34	3.91±1.38	3.68±1.41	3.29±1.51
Treatment	31	3.55±1.46	4.45±1.46^*▲	3.62±0.21^△

Group	n	Schirmer Ⅰ test
Group	n	Before treatment	After 1 course of treatment	One week after treatment
Control	34	4.47±1.93	4.76±2.05	4.24±1.82
Treatment	31	4.94±1.53	6.00±2.02^*▲	5.41±2.09^△▲

Effects of acupuncture on lactoferrin content in tears and tear secretion in patients suffering from dry eyes: A randomized controlled trial

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