[an error occurred while processing this directive]

Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (2): 113-115.doi: 10.3736/jcim20030208

Previous Articles     Next Articles

Study of an animal model of post-menopausal atherosclerosis in rabbit and observation of the effect of herbal formula of tonifying-kidney on it

Wen-jian Wang(), Zhen-yu Fei, Xiao-dong Fu, Wei-hua ChenN, Jian Ying, Feng Tang   

  1. Institute of Chinese Integrative Medicine, FU DAN University, Shanghai 200040, China
  • Received:2003-05-09 Online:2003-06-20 Published:2018-10-19

RichHTML

0

PDF (PC)

192

Cited

4

Like

Objective

To establish an animal model imitating post-menopausal atherosclerosis in rabbit and observe the effect of the herbal formula of tonifying-kidney on this animal model.


Methods

The New Zealand rabbits were treated with ovariectomy, high cholesterol diet plus immune injury, and both of ovariectomy and high cholesterol diet plus immune injury respectively. The blood lipid level and the intima and media of the aorta were observed.


Results

The rabbits treated with ovariectomy and high cholesterol diet plus immune injury changed markedly and had low level of estrogen, high levels of CHOL, TG and dysfunction of the arterial endothelium cells. However, the Chinese herbal formula of tonifying-kidney could relieve these changes.


Conclusion

The New Zealand rabbits treated with both of ovariectomy and high cholesterol diet plus immune injury could result in the changes imitating post-menopausal atherosclerosis, and it could be improved by the treatment of herbal formula of tonifying-kidney, so we think that the changes of the animal model are related to the deficiency of the kidney in traditional Chinese medicine.

Key words: post-menopause, atherosclerosis, deficiency of the kidney

CLC Number: 

  • R972-6

"

组别 n E2(pmol/L) Testosterone(μg/L) ET(pg/mL) NO(μmol/L)
对照组 10 89.60±9.55 0.16±0.03 91.31±33.54 99.00±16.76
去势组 8 75.58±12.50* 0.25±0.04* 109.02±22.44*△ 81.16±12.73*△
高脂组 10 88.84±10.03 0.16±0.03 133.59±26.88*△ 68.83±10.38*△
模型组 8 69.63±9.71* 0.23±0.07* 156.92±26.38* 59.44±13.54*
补肾组 7 73.92±11.78* 0.24±0.09* 126.83±18.53*△ 69.56±22.97*△

"

组别 n CHOL(mmol/L) TG(mmol/L) HDL-C(mmol/L) LDL-C(mmol/L) Apo-A(mg/L) Apo-B(mg/L)
对照组 10 1.78±0.32 0.83±0.25 0.48±0.15 1.81±0.27 0.35±0.01 0.09±0.01
去势组 8 2.14±0.26*△ 1.19±0.46*△ 0.45±0.08△ 1.74±0.51*△ 0.24±0.16*△ 0.14±0.07*△
高脂组 10 15.52±3.85*△ 1.90±0.51*△ 0.40±0.17*△ 6.89±1.80*△ 0.10±0.02*△ 0.75±0.11*△
模型组 8 20.34±3.99* 3.20±0.36* 0.36±0.19* 8.85±1.47* 0.04±0.01* 0.88±0.34*
补肾组 7 17.87±3.97*△ 2.80±0.88*△ 0.34±0.11* 8.00±2.07*△ 0.22±0.09*△ 0.22±0.05*△

"

组别 n 内膜厚度(μm) 中膜厚度(μm) 比值(％)
对照组 10 33.32±7.26 375.5±52.7 9.03±2.46
去势组 8 50.99±15.88 397.3±149.8 14.48±6.87
高脂组 10 202.43±30.89**△ 364.1±26.8 55.81±9.21**△
模型组 8 234.32±26.38** 354.4±69.8 67.95±12.80**
补肾组 7 110.12±10.26**△ 380.2±28.8 29.01±2.54**△
[1] Ferns GA, Forster L, Stewart-Lee A , et al. Probucol inhibits neointimal thickening and macrophage accumulation after balloon injury in the cholesterol-fed rabbit[J]. Proc Natl Acad Sci USA, 1992,89(23):11312-11316
doi: 10.1073/pnas.89.23.11312
[2] Xu G, Salen G, Shefer S , et al. Unexpected inhibition of cholesterol 7 alpha -hydroxylase by cholesterol in New Zealand white and watanabe heritable hyperlipidemic rabbits[J]. J Clin Invest, 1995,95(4):1497-1504
[3] 罗心平, 范维琥, 李勇 , 等. 麝香保心丸对高脂血症兔动脉壁保护作用的形态学研究[J]. 上海医药, 1997,18(9):23-24
[4] 陈名道, 杨颖 . 绝经妇女激素替代治疗的困境与中医药治疗更年期综合征的前景[J]. 中西医结合学报, 2003,1(1):9-11
[1] Mei-jiao Mao, Jun-ping Hu, Cong Wang, Yi-yi Zhang, Ping Liu. Effects of Chinese herbal medicine Guanxinkang on expression of PPARγ-LXRα-ABCA1 pathway in ApoE-knockout mice with atherosclerosis. Journal of Chinese Integrative Medicine, 2012, 10(7): 814-820.
[2] Chuan Chen, Hui-ying Chi, Zhi-hua Yu, Jiu-lin Chen . Effects of Chinese herbal medicine Shoushen Granule on telomere length and telomerase activity of peripheral white blood cells and vascular cells in rats with atherosclerosis. Journal of Chinese Integrative Medicine, 2012, 10(6): 667-673.
[3] Lei Liu, Yuan-hui Guo , Hai-liang Xin , Yan Nie , Ting Han, Lu-ping Qin , Oiao-yan Zhang. Antiosteoporotic effects of benzylbenzoate glucosides from Curculigo orchioides in ovariectomized rats. Journal of Chinese Integrative Medicine, 2012, 10(12): 1419-1426.
[4] Yan Wang, Hong-yan Zhao, Mei-jie Liu, Cheng Xiao, Cheng Lü, Yong Tan, Qing-lin Zha, Yan Li, Hong Liu, Ai-ping Lü, Da-hong Ju. Establishment of a rat model of rheumatoid arthritis with kidney deficiency syndrome. Journal of Chinese Integrative Medicine, 2011, 9(9): 973-982.
[5] Mao Mei-jiao, Hu Jun-ping, Chen Fu-rong, Zhang Yi-yi, Liu Ping. Effects of Chinese herbal medicine Guanxinkang on lipid metabolism and serum C-reactive protein, amyloid A protein, and fibrinogen in apolipoprotein E-knockout mice with atherosclerosis. Journal of Chinese Integrative Medicine, 2011, 9(3): 306-312.
[6] Lei Bao, Shi-en Zou, Shao-fen Zhang. Dose-dependent effects of daidzein in regulating bone formation through estrogen receptors and peroxisome proliferator-activated receptor γ. Journal of Chinese Integrative Medicine, 2011, 9(2): 165-172.
[7] Yi Xin, Tian-fang Wang, Cai-feng Du, Li Li, Jie Ren, Zhe Jin, Hong Zhao, Xiao-juan Zou , Hong-qi Liu, Ying Chen, Li-na Wang, Rui-fen Liu, Qing-guo Wang. Distribution characteristics of common syndrome types and syndrome elements extracted by experts' experience in perimenopausal and postmenopausal women. Journal of Chinese Integrative Medicine, 2009, 7(6): 522-526.
[8] Jian-nan Song, Jun-lian Liu, Xiang-zhong Fang, Yuan-hui Hu, Yan Lei, Xiao-hong Niu, Gang Wu, Bao-sheng Chen, Ya-luan Ma, Bing Chen, Hong jin. Relationship between plasma protein expression profiles and states of Zang-Fu organs in patients with phlegm or blood stagnation syndromes due to hyperlipidemia and atherosclerosis. Journal of Chinese Integrative Medicine, 2008, 6(12): 1233-1237.
[9] Jie-mei Zhang, Jie Guo, Xin Tu, Zhao-hong Shi, Jian-jun Hao, Yu-he Ke, Jiang-feng Guan, Juan-juan He. Protective effect of Huaxia shallot preparation on human umbilical vein endothelial cell injury induced by oxidized low density lipoprotein and its mechanism. Journal of Chinese Integrative Medicine, 2007, 5(6): 675-680.
[10] Guo-ju Dong, Jian-gang Liu, Da-zhuo Shi, Yong-yan Wang, Lian-jun Luan, Yi-yu Cheng. Effects of water extractives of a qi and blood regulating prescription on early atherosclerosis of apolipoprotein E-deficient mice. Journal of Chinese Integrative Medicine, 2007, 5(1): 45-49.
[11] Qiang Wang​, Kun-zheng Wang​, Guang-ye Wang​. Effects of soybean isoflavones on expression levels of osteoprotegerin and osteoprotegerin ligand mRNAs in bone tissues of ovariectomized rats. Journal of Chinese Integrative Medicine, 2006, 4(3): 303-306.
[12] Hao-zhu Chen. Current status of blood lipid level and treatment of hyperlipoidemia in Chinese population. Journal of Chinese Integrative Medicine, 2004, 2(2): 81-82.
[13] Qin-shan Li, Gui-yu Lou, Min-zhang Qian. Effect of hesperidin and rutin on oxidative modification of high density lipoprotein in vitro. Journal of Chinese Integrative Medicine, 2004, 2(2): 115-116.
[14] Yan-hao Xiong, Ning Du, Wei-zhen Chen, Tao Liu, Xu-sheng Tang. Retrospective study of the relationship of height difference and bone density of postmenopausal women. Journal of Chinese Integrative Medicine, 2003, 1(4): 265-267.
[15] Xiao-shan Zhao, Ren Luo. Study of genes related with kidney deficiency syndrome. Journal of Chinese Integrative Medicine, 2003, 1(1): 18-20.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228
[an error occurred while processing this directive]