家兔绝经后动脉粥样硬化模型的建立及补肾治疗对其的影响

doi:10.3736/jcim20030208

Abstract

Objective

To establish an animal model imitating post-menopausal atherosclerosis in rabbit and observe the effect of the herbal formula of tonifying-kidney on this animal model.

Methods

The New Zealand rabbits were treated with ovariectomy, high cholesterol diet plus immune injury, and both of ovariectomy and high cholesterol diet plus immune injury respectively. The blood lipid level and the intima and media of the aorta were observed.

Results

The rabbits treated with ovariectomy and high cholesterol diet plus immune injury changed markedly and had low level of estrogen, high levels of CHOL, TG and dysfunction of the arterial endothelium cells. However, the Chinese herbal formula of tonifying-kidney could relieve these changes.

Conclusion

The New Zealand rabbits treated with both of ovariectomy and high cholesterol diet plus immune injury could result in the changes imitating post-menopausal atherosclerosis, and it could be improved by the treatment of herbal formula of tonifying-kidney, so we think that the changes of the animal model are related to the deficiency of the kidney in traditional Chinese medicine.

Key words: post-menopause, atherosclerosis, deficiency of the kidney

CLC Number:

R972-6

Wen-jian Wang, Zhen-yu Fei, Xiao-dong Fu, Wei-hua Chen, Jian Ying, Feng Tang. Study of an animal model of post-menopausal atherosclerosis in rabbit and observation of the effect of herbal formula of tonifying-kidney on it. Journal of Chinese Integrative Medicine, 2003, 1(2): 113-115.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20030208

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组别	n	E₂(pmol/L)	Testosterone(μg/L)	ET(pg/mL)	NO(μmol/L)
对照组	10	89.60±9.55	0.16±0.03	91.31±33.54	99.00±16.76
去势组	8	75.58±12.50*	0.25±0.04*	109.02±22.44*^△	81.16±12.73*^△
高脂组	10	88.84±10.03	0.16±0.03	133.59±26.88*^△	68.83±10.38*^△
模型组	8	69.63±9.71*	0.23±0.07*	156.92±26.38*	59.44±13.54*
补肾组	7	73.92±11.78*	0.24±0.09*	126.83±18.53*^△	69.56±22.97*^△

组别	n	CHOL(mmol/L)	TG(mmol/L)	HDL-C(mmol/L)	LDL-C(mmol/L)	Apo-A(mg/L)	Apo-B(mg/L)
对照组	10	1.78±0.32	0.83±0.25	0.48±0.15	1.81±0.27	0.35±0.01	0.09±0.01
去势组	8	2.14±0.26*^△	1.19±0.46*^△	0.45±0.08^△	1.74±0.51*^△	0.24±0.16*^△	0.14±0.07*^△
高脂组	10	15.52±3.85*^△	1.90±0.51*^△	0.40±0.17*^△	6.89±1.80*^△	0.10±0.02*^△	0.75±0.11*^△
模型组	8	20.34±3.99*	3.20±0.36*	0.36±0.19*	8.85±1.47*	0.04±0.01*	0.88±0.34*
补肾组	7	17.87±3.97*^△	2.80±0.88*^△	0.34±0.11*	8.00±2.07*^△	0.22±0.09*^△	0.22±0.05*^△

组别	n	内膜厚度(μm)	中膜厚度(μm)	比值(％)
对照组	10	33.32±7.26	375.5±52.7	9.03±2.46
去势组	8	50.99±15.88	397.3±149.8	14.48±6.87
高脂组	10	202.43±30.89**^△	364.1±26.8	55.81±9.21**^△
模型组	8	234.32±26.38**	354.4±69.8	67.95±12.80**
补肾组	7	110.12±10.26**^△	380.2±28.8	29.01±2.54**^△

Study of an animal model of post-menopausal atherosclerosis in rabbit and observation of the effect of herbal formula of tonifying-kidney on it

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