橙皮苷与芦丁体外抗高密度脂蛋白氧化修饰的作用

doi:10.3736/jcim20040211

Abstract

Objective: To study the effect of hesperidin and rutin on oxidative modification of high density lipoprotein (HDL) in vitro.Methods: HDL was isolated from healthy human plasma by sequential ultracentrifugation, and was oxidized by copper ions. The inhibitory effects of hesperidin and rutin on HDL oxidative modification were valued by the formation of malondialdehyde (MDA). Results: Hesperidin and rutin significantly inhibited copper-induced oxidation of HDL in a dose-dependent manner.Conclusion: Both hesperidin and rutin can prevent HDL from copper-induced oxidative modification in vitro. This result suggests that they might have antiatherogenic effect.

Key words: hesperidin, rutin, high density lipoproteins, atherosclerosis

CLC Number:

R285

Qin-shan Li, Gui-yu Lou, Min-zhang Qian. Effect of hesperidin and rutin on oxidative modification of high density lipoprotein in vitro. Journal of Chinese Integrative Medicine, 2004, 2(2): 115-116.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20040211

http://www.jcimjournal.com/EN/Y2004/V2/I2/115

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References 7

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Group	n	MDA(μmol/L)
HDL	3	4.36±2.23
ox-HDL	3	29.54±2.27**
Hesperidin(3 mg/L)	3	25.00±0.08^△
Hesperidin(9 mg/L)	3	17.17±1.16^△△
Hesperidin(27 mg/L)	3	12.12±1.31^△△
Hesperidin(80 mg/L)	3	6.06±1.53^△△
Hesperidin(160 mg/L)	3	4.51±2.19^△△

Group	n	MDA（μmol/L）
HDL	3	4.36±2.23
ox-HDL	3	29.54±2.27**
Hesperidin(3 mg/L)	3	27.27±2.18
Hesperidin(9 mg/L)	3	19.69±1.36 ^△△
Hesperidin(27 mg/L)	3	15.15±2.62 ^△△
Hesperidin(80 mg/L)	3	9.85±1.39 ^△△
Hesperidin(160 mg/L)	3	6.06±1.25^△△

Effect of hesperidin and rutin on oxidative modification of high density lipoprotein in vitro

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