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Journal of Chinese Integrative Medicine ›› 2003, Vol. 1 ›› Issue (3): 195-198.doi: 10.3736/jcim20030315

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Prognostic analysis of advanced non small cell lung cancer treated by sequential chemo-radiation therapy combined with traditional Chinese medicine: A report of 54 cases

Ming-quan Han(), Jin-mei Su, Hai-yin Huang, Wei-hong Long, Li-ping Qin, Ping Qin, Wei Liu, Zhao-ying Sheng   

  1. Department of Integrated Traditional Chinese and Western Medicine,Pulmonary Disease Hospital of Shanghai, Shanghai 200433, China
  • Received:2003-07-21 Online:2003-09-20 Published:2003-09-20

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Objective

To evaluate the influence of fewer courses and prolonged intervals of chemotherapy on survival rate of advanced non small cell lung cancer (NSCLC) patients treated by sequential chemo-radiation therapy combined with traditional Chinese medicine (TCM).


Methods

From Jan.2000 to Dec.2001, 54 untreated advanced NSCLC patients (2 stage Ⅲa, 18 stage Ⅲb, 34 stage Ⅳ) were treated by sequential chemo-radiation therapy combined with TCM. The courses of chemotherapy were reduced and the intervals of chemotherapy were longer than that of the standard regimen. The efficacy and survival rate were documented and the prognostic factors were analyzed.


Results

Complete remission (CR) was observed in 1 case and partial remission (PR) in 20 cases. The overall objective response rate was 40.4%. Median survival was 15.3 months, 1-, 2- and 3- year survival rate were 53.7%, 28.9% and 9.6% respectively. The median survival of stage Ⅲ and Ⅳ were 21.8 months and 12.5 months respectively. The 1-, 2-, and 3- year survival rates of stage Ⅲ were 65.0%,49.5%, 24.7% and that of stage Ⅳ were 47.0%, 23.3%, 0%, respectively. The quality of life was improved in most of the patients. Cox's proportional hazards regression showed that improved quality of life and treatment of TCM were the significant prognostic factors of overall survival.


Conclusion

Chemotherapy and radiotherapy combined with TCM is beneficial to extending the interval of chemotherapy, improving the quality of life, and increasing the survival rate of advanced NSCLC patients.

Key words: advanced NSCLC, prognostic factor, survival time, quality of life, chemotherapy, radiotherapy, drugs, Chinese herbal

CLC Number: 

  • R734.2

"

患者类别 n 1年生存率（%） 2年生存率（%） 3年生存率（%） 中位生存期（月）
Ⅲ期 20 65.0 49.5 24.7 21.8
Ⅳ期 34 47.0 23.3 0 12.5
全部患者 54 53.7 28.9 9.6 15.3

"

变量 回归系数(β) 标准误（Sx） P值 相对危险度[Exp(β)]
性别 -0.458 0.371 0.217 0.632
年龄 0.554 0.317 0.080 1.740
病理类型 0.028 0.210 0.893 1.029
TNM分期 0.734 0.361 0.042 2.084
近期疗效 0.741 0.289 0.010 2.098
Karnofsky评分 -1.182 0.217 0.000 0.307
化疗疗程 -0.469 0.182 0.010 0.626
化疗间隔时间 -0.538 0.172 0.002 0.584
放疗 -0.407 0.277 0.142 0.666
中药治疗 -1.120 0.340 0.001 0.326

"

变量 回归系数(β) 标准误（Sx） P值 相对危险度[Exp(β)]
性别 -0.074 0.537 0.890 0.928
年龄 -0.038 0.483 0.938 0.963
病理类型 0.509 0.290 0.079 1.663
TNM分期 0.455 0.448 0.310 1.576
近期疗效 0.339 0.362 0.349 1.404
Karnofsky评分 -1.282 0.329 0.000 0.277
化疗疗程 -0.445 0.301 0.139 0.641
化疗间隔时间 -0.341 0.275 0.215 0.711
放疗 -0.231 0.387 0.550 0.794
中药治疗 -1.321 0.511 0.010 0.267
[1] 吴一龙 . 非小细胞肺癌的治疗——2001年ASCO会议综述之三[J]. 癌症, 2001,20(11):1317-1318
[2] Le Chevalier T, Arriagada R, Tarayre M , et al. Significant effect of adjuvant chemotherapy on survival in locally advanced non-small cell lung carcinoma[J]. J Natl Cancer Inst, 1992,84(1):58-63
doi: 10.1093/jnci/84.1.58
[3] Sause WT, Scott C, Taylor S , et al. Radiation Therapy Oncology Group(RTOG) 88-08 and Eastern Cooperative Oncology Group(ECOG) 4588: preliminary results of a phase Ⅲ trial in regionally advanced, unresectable non-small-cell lung cancer[J]. J Natl Cancer Inst, 1995,87(3):198-205
doi: 10.1093/jnci/87.3.198
[4] 刘嘉湘, 施志明, 李和根 , 等. 益肺抗瘤饮治疗271例非小细胞肺癌临床观察[J]. 上海中医药杂志, 2001,35(2):4-6
[5] 李邦华, 曾纪权, 袁国庆 . 益气养阴散结加化疗治疗Ⅲ期非小细胞肺癌临床观察[J]. 江西中医药, 2001,32(1):21-22
[6] Dillman RO, Herndon J, Seagren SL , et al. Improved survival in stage Ⅲ non-small-cell lung cancer: seven-year follow-up of cancer and leukemia group B(CALGB) 8433 trial[J]. J Natl Cancer Inst, 1996,88(17):1210-1215
doi: 10.1093/jnci/88.17.1210
[7] Chu DT, Zhang XR, Li JL , et al. The treatment of advanced non-small-cell lung cancer(NSCLC) --overseas updated and local experiences[J]. Gan To Kagaku Ryoho, 2002,29(Suppl 1):117-124
[8] Millward MJ, Boyer MJ, Lehnert M , et al. Docetaxel and carboplatin is an active regimen in advanced non-small-cell lung cancer: a phase Ⅱ study in Caucasian and Asian patients[J]. Ann Oncol, 2003,14(3):449-454
doi: 10.1093/annonc/mdg118
[9] Cardenal F, Domine M, Massuti B , et al. Three-week schedule of irinotecan and cisplatin in advanced non-small-cell lung cancer: a multicenter phase Ⅱ study[J]. Lung Cancer, 2003,39(2):201-207
doi: 10.1016/S0169-5002(02)00512-3
[10] Zaniboni A, Ardizzoni A, De Marinis F , et al. Phase Ⅱ study of Taxol combined with ifosfamide and carboplatin in the treatment of stage ⅢB-Ⅳ non-small-cell lung cancer[J]. Am J Clin Oncol, 2003,26(1):84-88
doi: 10.1097/00000421-200302000-00016
[11] Montazeri A, Milroy R, Hole D , et al. Quality of life in lung cancer patients as an important prognostic factor[J]. Lung Cancer, 2001,31(2-3):223-240
doi: 10.1016/S0169-5002(00)00179-3 pmid: 11165402
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