宫环止血片止血及镇痛作用的实验研究

doi:10.3736/jcim20040216

Abstract

Objective: To explore the hemostatic and analgesic effect of Gonghuan Zhixue Tablet (GHZXT) on mice and to produce experimental evidence for exploiting new drug for endometrorrhagia caused by Cu-intrauterine contraceptive device (Cu-IUD). Methods: Compared with 6-aminocaproic acid and notoginseng, the effects of GHZXT on clotting and bleeding time of mice with capillary method and severed tail were investigated; and compared with aspirin, the analgesic effects of GHZXT on mice were investigated with hot plate and torsive body method. Results: The clotting time of mice was remarkably shortened with a rising of the dosage of GHZXT and the difference between each therapeutic group and distilled water group was remarkable. As compared with distilled water group, the bleeding time of each dosage group of GHZXT was obviously shortened; and each dosage of GHZXT could prolong the time of pain reaction to hot plate and decrease the degree of torsive body of the mice. Conclusion: Pharmacological experiment has proved that GHZXT has evident hemostatic and analgesic function.

Key words: Gonghuan Zhixue Tablet, blood clotting, analgesia, animals, laboratory

CLC Number:

R965

Ling-mei Fu, Zhao-ling You, Lei Lei, Le-xi Wen, Huai-min Chen. Hemostatic and analgesic effect of Gonghuan Zhixue Tablet on mice. Journal of Chinese Integrative Medicine, 2004, 2(2): 129-131.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20040216

http://www.jcimjournal.com/EN/Y2004/V2/I2/129

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References 5

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[2]	戴德英 . 现代中医药应用与研究大系(第7卷)[M]. 上海: 上海中医药大学出版社, 1995,( 第7卷):280-295
[3]	尤昭玲, 王若光 . 宫内节育器引起异常子宫出血中医治疗评述[J]. 湖南中医药导报, 1998,4(3):10-11
[4]	王若光, 雷磊, 付灵梅 , 等. 尤昭玲教授论治宫环出血的经验[J]. 新中医, 2002,34(1):12-14 doi: 10.3969/j.issn.0256-7415.2002.01.005
[5]	李仪奎 . 中药药理学(第1版)[M]. 北京: 中国中医药出版社, 1992,( 第1版):126-128

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Group	Dosage （g/kg）	n	Clotting time（s）	Bleeding time（s）
Distilled water	-	10	343.50±21.61	230.60±13.13
6-aminocaproic acid	0.78	10	267.90±24.55*	159.50±13.36*
Notoginseng	1.04	10	248.90±25.73*	150.60±14.10*
Low dosage of GHZXT	0.44	10	273.50±9.82*^△	145.80±12.76*^▲
Middle dosage of GHZXT	1.31	10	259.40±10.56*	140.90±11.64*^▲▲
High dosage of GHZXT	3.94	10	250.50±17.14*^▲	124.40±22.42*^△△▲▲

Group	Dosage （g/kg）	n	Pain threshold（s）
Group	Dosage （g/kg）	n	30 min	60 min	90 min	120 min
Distilled water	-	10	3.5±1.6	2.5±1.2	2.2±1.4	1.6±0.9
Low dosage of GHZXT	0.44	10	8.3±3.2^{*□□■■}	10.1±5.9**^□□■■	6.9±2.3*^□□■■	4.5±1.2*^□□■■
Middle dosage of GHZXT	1.31	10	11.4±8.9**^△△▲	14.8±8.9**^□□■	9.3±3.2**^□□	7.6±2.3**^□□■
High dosage of GHZXT	3.94	10	16.9±7.6**	18.8±9.4**	13.8±8.9**	9.5±3.4**
Aspirin	0.2	10	18.7±12.4**	20.7±16.4**	15.8±9.6**	10.5±6.3**

Group	Dosage（g/kg）	n	Torsive body reaction
Group	Dosage（g/kg）	n	Cases	Frequencies
Distilled water	-	10	10	50.2±23.8
Low dosage of GHZXT	0.44	10	8	25.6±11.6**^□□■■
Middle dosage of GHZXT	1.31	10	7	22.7±13.5**^□□■
High dosage of GHZXT	3.94	10	7	19.8±10.6**^□
Aspirin	0.20	10	6	16.8±12.8**

Hemostatic and analgesic effect of Gonghuan Zhixue Tablet on mice

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