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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (3): 195-198.doi: 10.3736/jcim20050309

• Original Clinical Research • Previous Articles     Next Articles

Effects of perioperative administration of rhubarb on acute inflammatory response in patients with gastric cancer

Jun Cai,Zheng-rong Xuan,Yong-ping Wei,Hai-bo Yang,Hua Wang   

  1. Department of General Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
  • Received:2005-03-18 Online:2005-05-20 Published:2005-05-20
  • Contact: Jun Cai E-mail:caijun509@yahoo.com.cn

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Objective

To observe the effect of perioperative administration of rhubarb on the acute inflammatory response in patients with gastric cancer.

Methods

In this prospective, single-blinded, controlled clinical trial, thirty-one patients with gastric cancer operatively treated were randomly divided into two groups, with 14 patients in control group and 17 in study group. Patients in both groups were given an isocaloric and isonitrogenous enteral diet. The enteral diet was started 36 hours after operation, and continued for 6 days. Patients in the study group were fed with rhubarb before operation, and at 1 day and 2 days after operation. Indexes of acute inflammatory response such as serum C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α), and indexes of nutritional status such as serum albumin (ALB), prealbumin (PA) and transferrin (TRF) were measured before operation, and at 1 day, 3 and 7 days after operation.

Results

Patients in both groups had acute inflammatory response, and the indexes of nutritional status decreased after operation. IL-6, CRP and TNF-α tested at 3 and 7 days after operation were lower in the study group as compared with those in the control group, and the recovery time of gastrointestinal motility such as borborygmus, gas elimination and defecation was shorter in the study group as compared with that in the control group. The indexes of nutritional status showed no significant differences between two groups after operation.

Conclusion

Rhubarb can positively modulate the acute inflammatory response, promote the recovery of postoperative gastrointestinal motility, and benefit enteral nutrition support in patients who have undergone major operations for gastric cancer.

Key words: Stomach neoplasms, Rheum palmatum, Cytokines, Enteral nutrition

CLC Number: 

  • R735.2

Tab 1

Changes of indexes of inflammatory responses in two groups ($\bar{x}$±s)"

Group n CRP (mg/L) TNF-α (ng/L) IL-6 (ng/L)
Study group
Before operation 17 0.84± 0.23 40.50±18.46 12.58±4.31
1 day after operation 17 48.37±26.41△ 67.81±23.40△ 26.74±7.43△
3 days after operation 17 12.63±7.81*△ 53.41±18.97*△ 20.08±5.85*△
7 days after operation 17 5.14±2.37*△ 45.84±17.83* 15.82±6.44*
Control group
Before operation 14 0.73±0.35 39.86±17.34 13.27±5.44
1 day after operation 14 46.92±31.73△ 68.03±29.71△ 28.56±8.23△
3 days after operation 14 29.62±19.03△ 66.23±15.94△ 26.84±10.67△
7 days after operation 14 17.58±11.61△ 62.45±25.89△ 22.57±8.03△

Tab 2

Changes of indexes of nutritional status in two groups ($\bar{x}$±s, g/L)"

Group n ALB PA TRF
Study group
Before operation 17 34.58±4.16 24.16±6.25 264.59±65.23
1 day after operation 17 30.33±3.47△ 17.98±4.57△ 178.47±52.88△
3 days after operation 17 30.85±3.74△ 19.59±6.78△ 215.42±61.07△
7 days after operation 17 32.75±3.89 24.05±7.18 281.61±62.56
Control group
Before operation 14 34.87±3.37 23.81±5.46 268.22±54.39
1 day after operation 14 31.05±4.60△ 18.54±5.79△ 191.50±48.88△
3 days after operation 14 31.35±4.11△ 19.32±5.44△ 220.52±52.64△
7 days after operation 14 32.81±3.97 22.70±6.95 252.09±56.13

Tab 3

Recovery time of gastrointestinal motility in two groups ($\bar{x}$±s, h)"

Group n Borborygmus Gas elimination Defecation
Study group 17 43.2±13.4* 52.6±12.7* 67.4±17.8*
Control group 14 56.5±16.8 80.6±18.2 87.4±21.5
[1] De Blaauw I , Deutz NEP, von Meyenfeldt MF.Metabolic changes in cancer cachexia--first of two parts[J]. Clin Nutr, 1997,16(4):169-176
doi: 10.1016/S0261-5614(97)80002-7 pmid: 16844595
[2] Tisdale MJ . Cancer cachexia: metabolic alterations and clinical manifestations[J]. Nutrition, 1997,13(1):1-7
doi: 10.1016/S0899-9007(96)00313-9 pmid: 9058439
[3] Yoshida S, Matsui M, Shirouzu Y , et al. Effects of glutamine supplements and radiochemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer[J]. Ann Surg, 1998,227(4):485-491
doi: 10.1097/00000658-199804000-00006
[4] 吴国豪, 王浩, 张延伟 , 等. 消化道肿瘤手术后早期应用免疫增强型肠内营养的作用[J]. 肠外与肠内营养, 2003,10(1):8-11, 14
doi: 10.3969/j.issn.1007-810X.2003.01.003
[5] 彭淑梅, 王淑珍, 赵建平 . 大黄对全身炎症反应综合征患儿炎性因子和补体的影响及意义[J]. 中国中西医结合杂志, 2002,22(4):264-266
[6] 乔林, 陈德昌, 景炳文 , 等. 大黄对烫伤后大鼠肠粘膜上皮细胞线粒体功能的影响[J]. 中华急诊医学杂志, 2002,11(1):16-18
[7] 陈德昌, 景炳文, 杨兴易 , 等. 大黄对危重症患者胃肠道的保护作用[J]. 中国危重急救医学, 2000,12(2):87-90
[8] 李永渝, 魏玉, 李莉娟 , 等. 藿香、大黄等CCB中药影响胃肠道运动功能的机制探讨[J]. 中国中西医结合外科杂志, 1997,3(3):187-190
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