大黄对胃癌手术患者急性炎性反应的调理作用

doi:10.3736/jcim20050309

Abstract

Objective

To observe the effect of perioperative administration of rhubarb on the acute inflammatory response in patients with gastric cancer.

Methods

In this prospective, single-blinded, controlled clinical trial, thirty-one patients with gastric cancer operatively treated were randomly divided into two groups, with 14 patients in control group and 17 in study group. Patients in both groups were given an isocaloric and isonitrogenous enteral diet. The enteral diet was started 36 hours after operation, and continued for 6 days. Patients in the study group were fed with rhubarb before operation, and at 1 day and 2 days after operation. Indexes of acute inflammatory response such as serum C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α), and indexes of nutritional status such as serum albumin (ALB), prealbumin (PA) and transferrin (TRF) were measured before operation, and at 1 day, 3 and 7 days after operation.

Results

Patients in both groups had acute inflammatory response, and the indexes of nutritional status decreased after operation. IL-6, CRP and TNF-α tested at 3 and 7 days after operation were lower in the study group as compared with those in the control group, and the recovery time of gastrointestinal motility such as borborygmus, gas elimination and defecation was shorter in the study group as compared with that in the control group. The indexes of nutritional status showed no significant differences between two groups after operation.

Conclusion

Rhubarb can positively modulate the acute inflammatory response, promote the recovery of postoperative gastrointestinal motility, and benefit enteral nutrition support in patients who have undergone major operations for gastric cancer.

Key words: Stomach neoplasms, Rheum palmatum, Cytokines, Enteral nutrition

CLC Number:

R735.2

Jun Cai, Zheng-rong Xuan, Yong-ping Wei, Hai-bo Yang, Hua Wang. Effects of perioperative administration of rhubarb on acute inflammatory response in patients with gastric cancer. Journal of Chinese Integrative Medicine, 2005, 3(3): 195-198.

/ / Recommend

Add to citation manager EndNote| Reference Manager|ProCite|BibTeX|RefWorks

URL: http://www.jcimjournal.com/EN/10.3736/jcim20050309

http://www.jcimjournal.com/EN/Y2005/V3/I3/195

TrendMD

Figures/Tables 3

Tab 1

Tab 2

Tab 3

References 8

[1]	De Blaauw I , Deutz NEP, von Meyenfeldt MF.Metabolic changes in cancer cachexia--first of two parts[J]. Clin Nutr, 1997,16(4):169-176 doi: 10.1016/S0261-5614(97)80002-7 pmid: 16844595
[2]	Tisdale MJ . Cancer cachexia: metabolic alterations and clinical manifestations[J]. Nutrition, 1997,13(1):1-7 doi: 10.1016/S0899-9007(96)00313-9 pmid: 9058439
[3]	Yoshida S, Matsui M, Shirouzu Y , et al. Effects of glutamine supplements and radiochemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer[J]. Ann Surg, 1998,227(4):485-491 doi: 10.1097/00000658-199804000-00006
[4]	吴国豪, 王浩, 张延伟 , 等. 消化道肿瘤手术后早期应用免疫增强型肠内营养的作用[J]. 肠外与肠内营养, 2003,10(1):8-11, 14 doi: 10.3969/j.issn.1007-810X.2003.01.003
[5]	彭淑梅, 王淑珍, 赵建平 . 大黄对全身炎症反应综合征患儿炎性因子和补体的影响及意义[J]. 中国中西医结合杂志, 2002,22(4):264-266
[6]	乔林, 陈德昌, 景炳文 , 等. 大黄对烫伤后大鼠肠粘膜上皮细胞线粒体功能的影响[J]. 中华急诊医学杂志, 2002,11(1):16-18
[7]	陈德昌, 景炳文, 杨兴易 , 等. 大黄对危重症患者胃肠道的保护作用[J]. 中国危重急救医学, 2000,12(2):87-90
[8]	李永渝, 魏玉, 李莉娟 , 等. 藿香、大黄等CCB中药影响胃肠道运动功能的机制探讨[J]. 中国中西医结合外科杂志, 1997,3(3):187-190

Related Articles 15

[1]	Ye-juan Jia, Tian-yu Li, Peng Han, Yu Chen, Li-jia Pan, Chun-sheng Jia. Effects of different courses of moxibustion treatment on intestinal flora and inflammation of a rat model of knee osteoarthritis. Journal of Integrative Medicine, 2022, 20(2): 173-181.
[2]	Hui Chen, Wei Feng, Ye Lu, Yi Yang, Zhong-hai Xin, Man Li, Li Xin, Ying-di Gong. Effects and mechanism of Chinese medicine Jiawei Yupingfeng in a mouse model of allergic rhinitis. Journal of Integrative Medicine, 2021, 19(4): 354-361.
[3]	Pádraic J.Dunne, Julie Lynch, Lucia Prihodova, Caoimhe O'Leary, Atiyeh Ghoreyshi, Sharee A. Basdeo, Donal J.Cox, Rachel Breen, Ali Sheikhi, Áine Carroll, Cathal Walsh, Geraldine McMahon, Barry White. Burnout in the emergency department: Randomized controlled trial of an attention-based training program. Journal of Integrative Medicine, 2019, 17(3): 173-180.
[4]	J.M. Oliver-Baxter, H.S. Whitford, D.A. Turnbull, M.J. Bond. Effects of vitamin supplementation on inflammatory markers and psychological wellbeing among distressed women: A randomized controlled trial. Journal of Integrative Medicine, 2018, 16(5): 322-328.
[5]	Uday P. Pratap, Hannah P. Priyanka, Karthik R. Ramanathan, Vishak Raman, Lalgi Hima, Srinivasan Thyagarajan. Noni (Morinda citrifolia L.) fruit juice delays immunosenescence in the lymphocytes in lymph nodes of old F344 rats. Journal of Integrative Medicine, 2018, 16(3): 199-207.
[6]	Xuan Liu, Li-juan Xiu, Jian-peng Jiao, Jing Zhao, Ying Zhao, Ye Lu, Jun Shi, Yong-jin Li, Min Ye, Yu-fang Gu, Xiao-wei Wang, Jing-yu Xu, Ci-an Zhang, Yong-ying Liu, Yun Luo, Xiao-qiang Yue. Traditional Chinese medicine integrated with chemotherapy for stage IV non-surgical gastric cancer: A retrospective clinical analysis. Journal of Integrative Medicine, 2017, 15(6): 469-475.
[7]	Lilian Uchoa Carneiro, Ilna Gomes da Silva, Mirian Eliza Alves de Souza, Wellington da Silva Côrtes, Mário Geraldo de Carvalho, Bruno Guimarães Marinho. Antinociceptive and anti-inflammatory activities of leaf extracts from Annona tomentosa R.E.Fr. Journal of Integrative Medicine, 2017, 15(5): 379-387.
[8]	Shi-li Jiang, Xu-dong Hu, Ping Liu. Immunomodulation and liver protection of Yinchenhao decoction against concanavalin A-induced chronic liver injury in mice. Journal of Integrative Medicine, 2015, 13(4): 262-268.
[9]	Ci-an Zhang, Feng Wu, Zhu-jun Mao, Zhen Wei, Yong-jin Li, Pin-kang Wei. Effects of ethanol extract of Rhizome Pinelliae Preparata on intracellular pH value of human gastric adenocarcinoma cells. Journal of Chinese Integrative Medicine, 2011, 9(8): 894-900.
[10]	Jun Shi, Pin-kang Wei. The phlegm theory of gastric cancer. Journal of Chinese Integrative Medicine, 2011, 9(6): 581-587.
[11]	Jun Shi, Pin-kang Wei. Eight therapies of resolving phlegm and dispersing nodules in treatment of gastric cancer: Experience from Professor Wei Pin-kang. Journal of Chinese Integrative Medicine, 2011, 9(10): 1066-1069.
[12]	Wen Sun, Jian Yu, Yu-min Shi, Hao Zhang, Ying Wang, Bing-bing Wu. Effects of Cordyceps extract on cytokines and transcription factors in peripheral blood mononuclear cells of asthmatic children during remission stage. Journal of Chinese Integrative Medicine, 2010, 8(4): 341-346.
[13]	Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013.
[14]	NN Liu, N Zhou, Y Wang, X Liu, LH Zhou, Q Wu, J Sun, ZZ Fan, Q Li. Chinese herbal medicine Jianpi Jiedu Formula down-regulates the expression of vascular endothelial growth factor in human gastric cell line MKN45 induced by Helicobacter pylori by inhibiting cyclooxygenase-2. Journal of Chinese Integrative Medicine, 2010, 8(10): 968-973.
[15]	Zhi-ping Dong , Zhi-qian Hu, Wei Peng, Zhi-jun Shu, Ye-min Cao, Lei Lu. Effects of Baihe Recipe on expressions of vascular endothelial growth factor and p53 proteins in tumor tissues of nude mice bearing orthotopically transplanted gastric carcinoma BGC-823. Journal of Chinese Integrative Medicine, 2009, 7(5): 458-462.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

Comments

Recommended 10

[1]	Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2]	Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3]	Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4]	Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5]	. Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6]	Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7]	Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8]	Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9]	Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10]	Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228

Group	n	CRP (mg/L)	TNF-α (ng/L)	IL-6 (ng/L)
Study group
Before operation	17	0.84± 0.23	40.50±18.46	12.58±4.31
1 day after operation	17	48.37±26.41^△	67.81±23.40^△	26.74±7.43^△
3 days after operation	17	12.63±7.81*^△	53.41±18.97*^△	20.08±5.85*^△
7 days after operation	17	5.14±2.37*^△	45.84±17.83*	15.82±6.44*
Control group
Before operation	14	0.73±0.35	39.86±17.34	13.27±5.44
1 day after operation	14	46.92±31.73^△	68.03±29.71^△	28.56±8.23^△
3 days after operation	14	29.62±19.03^△	66.23±15.94^△	26.84±10.67^△
7 days after operation	14	17.58±11.61^△	62.45±25.89^△	22.57±8.03^△

Group	n	ALB	PA	TRF
Study group
Before operation	17	34.58±4.16	24.16±6.25	264.59±65.23
1 day after operation	17	30.33±3.47^△	17.98±4.57^△	178.47±52.88^△
3 days after operation	17	30.85±3.74^△	19.59±6.78^△	215.42±61.07^△
7 days after operation	17	32.75±3.89	24.05±7.18	281.61±62.56
Control group
Before operation	14	34.87±3.37	23.81±5.46	268.22±54.39
1 day after operation	14	31.05±4.60^△	18.54±5.79^△	191.50±48.88^△
3 days after operation	14	31.35±4.11^△	19.32±5.44^△	220.52±52.64^△
7 days after operation	14	32.81±3.97	22.70±6.95	252.09±56.13

Group	n	Borborygmus	Gas elimination	Defecation
Study group	17	43.2±13.4*	52.6±12.7*	67.4±17.8*
Control group	14	56.5±16.8	80.6±18.2	87.4±21.5

Effects of perioperative administration of rhubarb on acute inflammatory response in patients with gastric cancer

RichHTML

PDF (PC)

Cited

Like