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Journal of Chinese Integrative Medicine ›› 2005, Vol. 3 ›› Issue (6): 463-465.doi: 10.3736/jcim20050611

• Original Clinical Research • Previous Articles     Next Articles

Effect of ginseng fruit saponins on insulin sensitivity index in high fat-fed rats

Lan Luo1,Hui-jun Yin2,Ying Zhang2,Yue-rong Jiang2,Ying Liu2,Da-zhuo Shi2   

  1. 1. Department of Cardiovascular Diseases, Medical College, Jiamusi University, Jiamusi, Heilongjiang Province 154007, China
    2. Department of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Traditional Chinese Medcine, Beijing 100091, China
  • Received:2004-12-13 Online:2005-11-20 Published:2005-11-20
  • Contact: Hui-Jun YIN E-mail:huijunyin@yahoo.com.cn

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Objective

To observe the effect of ginseng fruit saponins (GFS) on insulin sensitivity index in high fat-fed rats.

Methods

An animal model of insulin resistance was established by injecting low dose of streptozotocin (STZ) in high fat-fed rats. Effect of GFS on insulin sensitivity was detected with glucose infusion rate (GIR) by euglycemic hyperinsulinemic clamp technique.

Results

The level of fasting blood glucose and insulin in untreated group increased more significantly than that in normal control group (P<0.05, P<0.01), while the index of GIR decreased significantly (P<0.01). As compared with the untreated group, the parameters of GFS-treated groups were improved significantly in a dosage-dependent manner (P<0.05, P<0.01).

Conclusion

GFS can improve experimental insulin resistance in rats.

Key words: Ginseng fruit saponins, Insulin resistance, Insulin sensitivity index

CLC Number: 

  • R733.72

Tab 1

Comparison of the values of blood glucose, serum insulin and insulin sensitivity index between normal control and high fat-fed groups ($\bar{x}$±s )"

Group n Blood glucose (mmol/L) Serum insulin (mU/L) Insulin sensitivity index
Normal control 10 4.24±0.88 35.56±4.27 –2.55±0.42
High fat-fed 10 5.34±1.27* 55.21±16.32** –3.59±0.38*

Tab 2

Effects of high fat feeding and different drugs on experimental data in each group ($\bar{x}$±s )"

Group n Fasting blood-glucose (mmol/L) Serum insulin (mU/L) GIR (mg·kg–1·min–1)
Normal control 10 4.56±0.32 42.01±0.47 12.41±1.86
Untreated 10 5.53±0.85** 136.20±0.48** 5.78±1.96**
High-dose GFS-treated 10 4.95±0.68△△ 73.50±0.75△△ 9.13±2.58△△
Low-dose GFS-treated 10 5.29±0.38△△ 93.80±0.57△△ 7.53±1.79△
Rosiglitazone-treated 10 4.48±0.74△△ 48.90±0.60△△ 12.56±3.18△△
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