补肾中药对去势后大鼠雌激素受体作用的实验研究

doi:10.3736/jcim20060108

Abstract

Objective

To observe the effects of recipe for invigorating kidney on expression of estrogen receptors in ovariectomized rats.

Methods

The rats, which were given high-cholesterol diet after ovariectomy, were chosen as experimental subjects. After fed kidney-invigorating recipe for 16 weeks, the rats were killed and the levels of serum lipid and estradiol of these rats were examined. The expressions of estrogen receptor α and β mRNAs in aorta, pituitary gland and hypothalamus, and the affinity of estrogen receptor-ligand were also detected.

Results

The kidney-invigorating recipe could increase the expression levels of estrogen receptor α and β mRNAs in different parts such as aorta, pituitary gland and hypothalamus, and enhance the affinity of estrogen receptor-ligands.

Conclusion

The recipe for invigorating kidney may meliorate atherosclerosis in ovariectomized rats by regulating the estrogen receptors.

Key words: Menopause, Arteriosclerosis, Receptors, Estrogen

CLC Number:

R984

Wen-bin Yang, Wen-jian Wang, Zhen-yu Fei. Effects of recipe for invigorating kidney on expression of estrogen receptors in ovariectomized rats. Journal of Chinese Integrative Medicine, 2006, 4(1): 26-29.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20060108

http://www.jcimjournal.com/EN/Y2006/V4/I1/26

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References 9

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Group	n	Estradiol (nmol/L)	TC (mmol/L)	TG (mmol/L)	LDL (mmol/L)	HDL (mmol/L)
Normal control	15	0.053±0.014	2.53±0.14	2.16±0.31	0.54±0.13	0.62±0.12
Untreated	15	0.026±0.012**	4.26±0.22**	4.75±0.50**	1.98±0.21**	0.24±0.03**
Kidney-invigorating recipe-treated	15	0.035±0.011*	2.95±0.11*^△	3.83±0.31**^△	1.41±0.12**^△	0.394±0.08**^△

Group	n	Expression of estrogen receptor α mRNA
Group	n	Aorta	Pituitary gland	Hypothalamus
Normal control	15	1.75±0.32	1.32±0.16	1.07±0.08
Untreated	15	0.47±0.09**	0.58±0.06**	0.36±0.04**
Kidney-invigorating recipe-treated	15	1.29±0.27*^△△	0.88±0.12**^△△	0.79±0.03*^△

Group	n	Expression of estrogen receptor α mRNA
Group	n	Aorta	Pituitary gland	Hypothalamus
Normal control	15	2.23±0.17	1.17±0.18	1.24±0.04
Untreated	15	0.56±0.12**	0.67±0.12**	0.83±0.15**
Kidney-invigorating recipe-treated	15	1.34±0.23*^△	0.83±0.15**	0.87±0.11*^△△

Group	n	Bmax (nmol/mg)		Ka
Group	n	Aorta	Hypothalamus	Aorta	Hypothalamus
Normal control	4	4.92±1.16	12.08±1.80	1.38±0.74	1.99±1.14
Untreated	4	3.18±0.46*	8.40±1.23*	0.56±0.23**	0.67±0.38**
Kidney-invigorating recipe-treated	4	4.19±0.97*^△	10.94±1.62^△	0.87±0.45*^△	1.26±0.89*^△△

Effects of recipe for invigorating kidney on expression of estrogen receptors in ovariectomized rats

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