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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (1): 15-21.doi: 10.3736/jcim20080104

• Editorial • Previous Articles     Next Articles

An explanation on "guiding principles of clinical research on mild cognitive impairment (protocol)"

Jin-zhou Tian1,2(), Jing Shi1, Xin-qing Zhang3, Qi Bi4, Xin Ma5, Zhi-liang Wang6, Xiao-bin Li6, Shu-li Shen3, Lin Li3, Zhen-yun Wu7, Li-yan Fang1, Xiao-dong Zhao1, Ying-chun Miao1, Peng-wen Wang1, Ying Ren1, Jun-xiang Yin1, Yong-yan Wang8, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments   

  1. 1. Department of Care of the Elderly, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
    2. Department of Preclinical Medicine, Hubei College of Chinese Medicine, Wuhan, Hubei Province 430061, China
    3. Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China
    4. Department of Neurology, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China
    5. Department of Geriatrics, Beijing Anding Hospital, Capital University of Medical Sciences, Beijing 100088, China
    6. North China Pharmaceutical Group Formulation Company Limited, Shijiazhuang, Hebei Province 050015, China
    7. Research Centre of Elderly Psychology, Institute of Psychology, China Academy of Sciences, Beijing 100101, China
    8. Institute of Clinical Basics, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • Received:2007-09-03 Online:2008-01-20 Published:2008-01-15
  • Contact: TIAN Jin-zhou

In order to provide the "guiding principles of clinical research on mild cognitive impairment (MCI) (protocol)" edited by Beijing United Study Group on MCI of the Capital Foundation of Medical Developments (CFMD) with evidence support, clinical criteria, subtypes, inclusion and exclusion of MCI, and use of rating scales were reviewed. The authors suggested that MCI clinical criteria and new diagnosis procedure from the MCI Working Group of the European Alzheimers disease Consortium (EADC) may better reflect the heterogeneity of MCI syndrome. Diagnostic rating scales including Clinical Dementia Rating (CDR), Global Deterioration Scale (GDS), Alzheimers Disease Assessment Scale-cognitive subscale (ADAS-cog) and Instrumental Activities of Daily Living (IADL) are very useful in definition of MCI but can not replace its clinical criteria. Absence of major repercussions on daily life in patients with MCI was emphasized, but the patients may have minimal impairment in complex IADL. According to their previous research, the authors concluded that highly recommendable neuropsychological scales with cut-off scores in the screening of MCI cases should include Mini-Mental State Examination (MMSE), logistic memory test such as Delayed Story Recall (DSR), executive function test such as Clock Draw Test (CDT),language test such as Verbal Category Fluency Test (VCFT), etc. And finally, the detection of biological and neuroimaging changes, including atrophy in hippocampus or medial temporal lobe in patients with MCI, was introduced.

Key words: cognition disorders, diagnosis, reference standards, guidebooks

CLC Number: 

  • R-62


组别 MMSE评分 CDR评分 DSR评分 CDT评分
正常组 28.09±1.73 0.32±0.24 26.50±9.27 3.77±0.69
记忆型轻度认知损害组 25.92±2.61** 0.50±0.12** 15.69±11.70** 3.22±1.11**
阿尔茨海默病组 23.03±5.90△ 0.58±0.41 7.59±4.87△△ 2.97±1.46
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