四君子汤联合肠内营养对胃癌手术患者T细胞亚群及营养状况影响的随机对照研究

doi:10.3736/jcim20080108

Abstract

Objective: To observe the effect of perioperative application of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation.

Methods:In this prospective, single-blinded, controlled clinical trial, fifty-nine patients with gastric cancer were randomly divided into three groups: control group (n = 20) and two study groups (group A, n = 21; group B,n = 18). Sjunzi Decoction (100 ml) was administered via nasogastric tube to the patients in the study group B from the second postoperation day to the 9th postoperation day. Patients in the two study groups were given an isocaloric and isonitrogonous enteral diet, which was started on the second day after operation, and continued for eight days. Patients in the control group were given an isocaloric and isonitrogonous parenteral diet for 9 days. All variables of nutritional status such as serum albumin (ALB), prealbumin (PA),transferrin (TRF) and T-cell subsets were measured one day before operation,and one day and 10 days after operation.

Results:All the nutritional variables and the levels of CD3 ⁺,CD4 ⁺,CD4 ⁺/CD8 ⁺ were decreased significantly after operation. Ten days after operation, T-cell subsets and nutritional variables in the two study groups were increased as compare with the control group. The levels of ALB, TRF and T-cell subsets in the study group B were increased significantly as compared with the study group A (P<0.05).

Conclusion:Enteral nutrition assisted with Sijunzi Decoction can positively improve and optimize cellular immune function and nutritional status in the patients with gastric cancer after operation.

Key words: stomach cancer, Sijunzi Decoction, T-cell subsets, enteral nutrition, nutritional status

CLC Number:

R735.2

Jun Cai, Hua Wang, Sheng Zhou, Bin Wu, Hua-rong Song, Zheng-rong Xuan. Effect of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(1): 37-40.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20080108

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Group	n	CD3⁺ (%)	CD4⁺ (%)	CD4⁺/CD8⁺
Control group
Before operation	20	66.33±9.57*	42.50±5.53*	1.65±0.37*
1 day after operation	20	50.64±7.20	33.48±4.87	1.39±0.39
10 days after operation	20	55.17±7.20	36.04±4.26	1.41±0.38
Study group A
Before operation	21	66.46±8.33*	42.39±6.51*	1.65±0.34*
1 day after operation	21	51.77±5.20	34.38±5.23	1.35±0.39
10 days after operation	21	60.95±7.77*^△	40.07±6.07*^△	1.50±0.56
Study group B
Before operation	18	71.64±11.36*	44.81±13.06*	1.96±1.11*
1 day after operation	18	58.59±11.08^△▲	28.41±11.87^▲	1.10±0.49^△
10 days after operation	18	71.92±13.14*^△▲	48.64±8.80*^△▲	2.24±0.88*^△▲

Group	n	ALB (g/L)	PA (mg/L)	TRF (g/L)
Control group
Before operation	20	36.03±5.53*	218.80±53.56*	1.93±0.27*
1 day after operation	20	30.80±3.27	171.30±37.95	1.47±0.23
10 days after operation	20	32.61±3.15	186.70±38.80	1.66±0.24*
Study group A
Before operation	21	35.36±3.63*	211.85±43.92*	1.90±0.44*
1 day after operation	21	29.64±2.76	166.47±56.18	1.46±0.22
10 days after operation	21	34.30±1.98*^△	224.85±73.36*^△	1.88±0.34*^△
Study group B
Before operation	18	33.58±5.32*	202.86±45.20*	1.81±0.15*
1 day after operation	18	28.62±4.13	155.42±36.56	1.43±0.16
10 days after operation	18	36.23±3.45*^△▲	227.52±39.76*^△	2.09±0.19*^△▲

Effect of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation: A randomized controlled trial

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