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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (1): 37-40.doi: 10.3736/jcim20080108

• Original Clinical Research • Previous Articles     Next Articles

Effect of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation: A randomized controlled trial

Jun Cai(), Hua Wang, Sheng Zhou, Bin Wu, Hua-rong Song, Zheng-rong Xuan   

  1. Department of General Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
  • Received:2007-07-12 Online:2008-01-20 Published:2008-01-15
  • Contact: CAI Jun E-mail:caijun509@yahoo.com.cn

Objective: To observe the effect of perioperative application of Sijunzi Decoction and enteral nutrition on T-cell subsets and nutritional status in patients with gastric cancer after operation.

Methods:In this prospective, single-blinded, controlled clinical trial, fifty-nine patients with gastric cancer were randomly divided into three groups: control group (n = 20) and two study groups (group A, n = 21; group B,n = 18). Sjunzi Decoction (100 ml) was administered via nasogastric tube to the patients in the study group B from the second postoperation day to the 9th postoperation day. Patients in the two study groups were given an isocaloric and isonitrogonous enteral diet, which was started on the second day after operation, and continued for eight days. Patients in the control group were given an isocaloric and isonitrogonous parenteral diet for 9 days. All variables of nutritional status such as serum albumin (ALB), prealbumin (PA),transferrin (TRF) and T-cell subsets were measured one day before operation,and one day and 10 days after operation.

Results:All the nutritional variables and the levels of CD3 +,CD4 +,CD4 +/CD8 + were decreased significantly after operation. Ten days after operation, T-cell subsets and nutritional variables in the two study groups were increased as compare with the control group. The levels of ALB, TRF and T-cell subsets in the study group B were increased significantly as compared with the study group A (P<0.05). 

Conclusion:Enteral nutrition assisted with Sijunzi Decoction can positively improve and optimize cellular immune function and nutritional status in the patients with gastric cancer after operation.

Key words: stomach cancer, Sijunzi Decoction, T-cell subsets, enteral nutrition, nutritional status

CLC Number: 

  • R735.2

Table 1

Changes of T-cell subsets in three groups ($\bar{x}$±s)"

Group n CD3+ (%) CD4+ (%) CD4+/CD8+
Control group
Before operation 20 66.33±9.57* 42.50±5.53* 1.65±0.37*
1 day after operation 20 50.64±7.20 33.48±4.87 1.39±0.39
10 days after operation 20 55.17±7.20 36.04±4.26 1.41±0.38
Study group A
Before operation 21 66.46±8.33* 42.39±6.51* 1.65±0.34*
1 day after operation 21 51.77±5.20 34.38±5.23 1.35±0.39
10 days after operation 21 60.95±7.77* 40.07±6.07* 1.50±0.56
Study group B
Before operation 18 71.64±11.36* 44.81±13.06* 1.96±1.11*
1 day after operation 18 58.59±11.08△▲ 28.41±11.87 1.10±0.49
10 days after operation 18 71.92±13.14*△▲ 48.64±8.80*△▲ 2.24±0.88*△▲

Table 2

Changes of indexes of nutritional status in three groups ($\bar{x}$±s)"

Group n ALB (g/L) PA (mg/L) TRF (g/L)
Control group
Before operation 20 36.03±5.53* 218.80±53.56* 1.93±0.27*
1 day after operation 20 30.80±3.27 171.30±37.95 1.47±0.23
10 days after operation 20 32.61±3.15 186.70±38.80 1.66±0.24*
Study group A
Before operation 21 35.36±3.63* 211.85±43.92* 1.90±0.44*
1 day after operation 21 29.64±2.76 166.47±56.18 1.46±0.22
10 days after operation 21 34.30±1.98* 224.85±73.36* 1.88±0.34*
Study group B
Before operation 18 33.58±5.32* 202.86±45.20* 1.81±0.15*
1 day after operation 18 28.62±4.13 155.42±36.56 1.43±0.16
10 days after operation 18 36.23±3.45*△▲ 227.52±39.76* 2.09±0.19*△▲
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