软坚消瘿汤治疗慢性淋巴细胞性甲状腺炎的临床研究

doi:10.3736/jcim20060407

Abstract

Objective

To evaluate the clinical outcome of Ruanjian Xiaoying Decoction (RJXYD) on chronic lymphocytic thyroiditis.

Methods

Eighty patients with chronic lymphocytic thyroiditis were randomly divided into RJXYD-treated group (n=40) and control group (n=40). The patients in the RJXYD-treated group received treatment of RJXYD combined with levothyroxine while the others in the control group received treatment of levothyroxine and prednisone both for 16 weeks. The serum levels of thyroid hormones and the titres of serum antithyroglobulin antibody (anti-TG Ab) and antithyroid microsomal antibody (anti-TM Ab) were all examined before and after treatment. The total response rates of the two groups were evaluated after treatment of 16 weeks.

Results

The total response rate of the RJXYD-treated group was 92.5%, while that of the control group was 60.0% (P＜0.01). The serum levels of free triiodothyronine (FT3) and free thyroxine (FT4) were obviously increased after treatment as compared with those before treatment in the two groups. The titres of serum anti-TG Ab and anti-TM Ab and the serum level of thyroid-stimulating hormone (TSH) were all obviously decreased after treatment as compared with those before treatment in the two groups.

Conclusion

The RJXYD can shrink and soften the enlarged thyroid gland and thyroid nodules, improve the immune function of human body, alleviate the response to thyroid self-antigens and promote the recovery of thyroid function.

Key words: Chronic lymphocytic thyroiditis, Ruanjian Xiaoying Decoction, Clinical research

CLC Number:

R581.4

Bang-jiang Fang, Li-hua Sun, Xi-qiu Zhou, Yun-hua Qiu. Effects of Ruanjian Xiaoying Decoction on chronic lymphocytic thyroiditis. Journal of Chinese Integrative Medicine, 2006, 4(4): 355-377.

/ / Recommend

Add to citation manager EndNote| Reference Manager|ProCite|BibTeX|RefWorks

URL: http://www.jcimjournal.com/EN/10.3736/jcim20060407

http://www.jcimjournal.com/EN/Y2006/V4/I4/355

trendmd

Figures/Tables 3

Table 1

Table 2

Table 3

References 4

[1]	方邦江, 周爽, 鲁新华.陈如泉运用活血消瘿汤治疗慢性淋巴细胞性甲状腺炎经验[J].中医杂志,2002,43(6):419 doi: 10.3321/j.issn:1001-1668.2002.06.015
[2]	王庆兆, 魏韬哲.现代甲状腺外科学(第1版)[M].郑州: 河南医科大学出版社,1997,(第1版):202
[3]	史轶蘩. 协和内分泌和代谢学(第1版)[M].北京: 科学出版社,1999,(第1版):1059-1065
[4]	高绪文, 李继莲.甲状腺疾病(第1版)[M].北京: 人民卫生出版社,1999,(第1版):137-138

Related Articles 15

[1]	Lu-ming Chen, Hui Yu, Da-rong Wu , Xun Hu , Lan Zheng. Investigation on response of the patient-reported outcome scale of the main-symptoms of chronic obstructive pulmonary disease complicated with pulmonary heart disease. Journal of Chinese Integrative Medicine, 2012, 10(9): 970-974.
[2]	Ming-xing Zhao, Zhen-hua Dong, Zhong-hai Yu, Shi-yuan Xiao, Ya-ming Li . Effects of Ginkgo biloba extract in improving episodic memory of patients with mild cognitive impairment: A randomized controlled trial. Journal of Chinese Integrative Medicine, 2012, 10(6): 628-634.
[3]	Jie-ning Wang, Sheng Ye, Dong-hai Yu, Hui Zhao, Le-yi Du. Practice and exploration on clinical evaluations of hospital-made Chinese herbal formulas in the Pudong New Area of Shanghai. Journal of Chinese Integrative Medicine, 2012, 10(10): 1084-1087.
[4]	Wan-li Gu , Zai-xiang Shi, Yun-xu Yu, Yu-wei Wu, Bao-wei Lu, Ka-kit Hui . Distribution characteristics of syndrome types in essential hypertension. Journal of Chinese Integrative Medicine, 2010, 8(9): 842-847.
[5]	Deng-hao Liu, Zheng Wang, Zhang-yan Qin. Clinical effects of Shugan Jianpi Recipe on postadolescent acne in women. Journal of Chinese Integrative Medicine, 2009, 7(7): 671-673.
[6]	Ya-jie Wang , Ha-fa Que. Clinical study of syndrome differentiation standards for chronic skin ulcer of lower limbs. Journal of Chinese Integrative Medicine, 2009, 7(12): 1139-1144.
[7]	Chung-wah Cheng, Zhao-xiang Bian, You-ping Li, David Moher, Tai-xiang Wu, Simon Dagenais, Jing Li, Ting-qian Li. Transparently reporting adverse effects of traditional Chinese medicine interventions in randomized controlled trials. Journal of Chinese Integrative Medicine, 2008, 6(9): 881-886.
[8]	Zhao-xiang Bian, David Moher, You-ping Li, Tai-xiang Wu, Simon Dangenais, Chung-wah Cheng, Jing Li, Ting-qian Li. Appropriately selecting and concisely reporting the outcome measures of randomized controlled trials of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2008, 6(8): 771-775.
[9]	Wei-rong Zhu, Shou-jie Zhang, De-hou Zheng, Xiao-heng Shen. Dishen Qufeng Decoction for treating allergic rhinitis: a randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(7): 700-703.
[10]	Fu-lun Li, Bin Li, Rong Xu, Xun Song, Yang Yu, Zheng-cheng Xu. Qinzhu Liangxue Decoction in treatment of blood-heat type psoriasis vulgaris: a randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(6): 586-589.
[11]	Yi-fei Wang, Bo-hua Li, Ming Zhang, Wen-bin Xu, Rong Zhou, Min Zhou. Stage-based treatment of gouty arthritis by combination therapy of traditional Chinese and Western medicines: a randomized controlled trial. Journal of Chinese Integrative Medicine, 2008, 6(6): 576-580.
[12]	Fan-rong Liang, Yong Tang. Acupuncture in treatment of cerebrosis: advances in clinical research over 20 years. Journal of Chinese Integrative Medicine, 2008, 6(6): 561-564.
[13]	Yi-ping Chen. Clinical study of integrative medicine in treatment of nephropathy: strategy and innovation. Journal of Chinese Integrative Medicine, 2008, 6(5): 446-448.
[14]	Chen Yue, Liang Zhu, Yi-ming Qian. Diagnostic value of assay of brain natriuretic peptide in patients with sepsis of blood-stasis syndrome. Journal of Chinese Integrative Medicine, 2008, 6(3): 266-269.
[15]	Ping Xie, Li-hui Deng, Zhao-da Zang, Qing Xia, Zong-wen Huang, Xiao-nan Yang, Jun-ming Jiang. Clinical study of Yihuo Qingxia method in treating hyperlipoidemia-related severe acute pancreatitis in early stage. Journal of Chinese Integrative Medicine, 2008, 6(3): 262-265.

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

Comments

Recommended 10

[1]	Jin-rong Fu. Establishment of multivariate diagnosis and treatment system of modern gynecology of traditional Chinese medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 22-24
[2]	Hao Li, Ming-jiang Yao, Wen-ming Zhao, Jie Guan, Lin-lin Cai, Ling Cui. A randomized, controlled, double-blind trial of Huannao Yicong capsule in senile patients with mild cognitive impairment. Journal of Chinese Integrative Medicine, 2008, 6(1): 25-31
[3]	Zhi-chun Jin. Problems in establishing clinical guideline for integrated traditional Chinese and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 5-8
[4]	SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[5]	Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[6]	Ning-qun Wang, Liang-duo Jiang, Zong-xing Li. Research progress in asthma-related quality of life. Journal of Chinese Integrative Medicine, 2008, 6(1): 93-97
[7]	Jing-yuan Mao, Chang-xiao Liu, Heng-he Wang, Guang-li Wei , Zhen-peng Zhang, Jie Xing, Wang Xian liang , Ying-fei Bi . Effects of Shenmai Injection on serum concentration and pharmacokinetics of digoxin in dogs with heart failure. Journal of Chinese Integrative Medicine, 2010, 8(11): 1070-1074
[8]	Zhi-mei Wang, Bin Zhang. A study on translation of ellipses in Huangdi Neijing from perspective of hermeneutic theory. Journal of Chinese Integrative Medicine, 2010, 8(11): 1097-1100
[9]	Gui Yu, Jie Wang. Thinking on building the network cardiovasology of Chinese medicine. Journal of Chinese Integrative Medicine, 2012, 10(11): 1206-1210
[10]	Pedro Saganha João, Doenitz Christoph, Greten Tobias, Efferth Thomas, J. Greten Henry. Qigong therapy for physiotherapists suffering from burnout: a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(11): 1233-1239

Group	n	Significant response	Partial response	Invalidity	Total response rate
RJXYD-treated	40	15 (37.5%)	22 (55.0%)	3 (7.5%)	92.5%**
Control	40	7 (17.5%)	17 (42.5%)	16 (40.0%)	60.0%

Group	n	FT3 (nmol/L)	FT4 (nmol/L)	TSH (mU/L)
RJXYD-treated
Before treatment	40	3.65±1.48	10.95±4.37	2.22±1.36
After treatment	40	5.98±1.66**^△△	15.10±1.89**^△△	1.35±1.19**
Control
Before treatment	40	3.53±1.55	11.01±4.06	2.19±1.36
After treatment	40	4.74±1.83**	13.42±2.01**	1.52±1.48*

Group	n	anti-TG Ab	anti-TM Ab
RJXYD-treated
Before treatment	40	53.13±11.65	47.65±8.07
After treatment	40	25.67±10.35**^△△	20.49±7.92**^△△
Control
Before treatment	40	52.82±10.93	47.32±7.91
After treatment	40	47.43±11.71*	39.68±9.67**

Effects of Ruanjian Xiaoying Decoction on chronic lymphocytic thyroiditis

RichHTML

PDF (PC)

Like