软坚消瘿汤治疗慢性淋巴细胞性甲状腺炎的临床研究

doi:10.3736/jcim20060407

Abstract

Objective

To evaluate the clinical outcome of Ruanjian Xiaoying Decoction (RJXYD) on chronic lymphocytic thyroiditis.

Methods

Eighty patients with chronic lymphocytic thyroiditis were randomly divided into RJXYD-treated group (n=40) and control group (n=40). The patients in the RJXYD-treated group received treatment of RJXYD combined with levothyroxine while the others in the control group received treatment of levothyroxine and prednisone both for 16 weeks. The serum levels of thyroid hormones and the titres of serum antithyroglobulin antibody (anti-TG Ab) and antithyroid microsomal antibody (anti-TM Ab) were all examined before and after treatment. The total response rates of the two groups were evaluated after treatment of 16 weeks.

Results

The total response rate of the RJXYD-treated group was 92.5%, while that of the control group was 60.0% (P＜0.01). The serum levels of free triiodothyronine (FT3) and free thyroxine (FT4) were obviously increased after treatment as compared with those before treatment in the two groups. The titres of serum anti-TG Ab and anti-TM Ab and the serum level of thyroid-stimulating hormone (TSH) were all obviously decreased after treatment as compared with those before treatment in the two groups.

Conclusion

The RJXYD can shrink and soften the enlarged thyroid gland and thyroid nodules, improve the immune function of human body, alleviate the response to thyroid self-antigens and promote the recovery of thyroid function.

Key words: Chronic lymphocytic thyroiditis, Ruanjian Xiaoying Decoction, Clinical research

CLC Number:

R581.4

Bang-jiang Fang, Li-hua Sun, Xi-qiu Zhou, Yun-hua Qiu. Effects of Ruanjian Xiaoying Decoction on chronic lymphocytic thyroiditis. Journal of Chinese Integrative Medicine, 2006, 4(4): 355-377.

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URL: http://www.jcimjournal.com/EN/10.3736/jcim20060407

http://www.jcimjournal.com/EN/Y2006/V4/I4/355

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References 4

[1]	方邦江, 周爽, 鲁新华.陈如泉运用活血消瘿汤治疗慢性淋巴细胞性甲状腺炎经验[J].中医杂志,2002,43(6):419 doi: 10.3321/j.issn:1001-1668.2002.06.015
[2]	王庆兆, 魏韬哲.现代甲状腺外科学(第1版)[M].郑州: 河南医科大学出版社,1997,(第1版):202
[3]	史轶蘩. 协和内分泌和代谢学(第1版)[M].北京: 科学出版社,1999,(第1版):1059-1065
[4]	高绪文, 李继莲.甲状腺疾病(第1版)[M].北京: 人民卫生出版社,1999,(第1版):137-138

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Group	n	Significant response	Partial response	Invalidity	Total response rate
RJXYD-treated	40	15 (37.5%)	22 (55.0%)	3 (7.5%)	92.5%**
Control	40	7 (17.5%)	17 (42.5%)	16 (40.0%)	60.0%

Group	n	FT3 (nmol/L)	FT4 (nmol/L)	TSH (mU/L)
RJXYD-treated
Before treatment	40	3.65±1.48	10.95±4.37	2.22±1.36
After treatment	40	5.98±1.66**^△△	15.10±1.89**^△△	1.35±1.19**
Control
Before treatment	40	3.53±1.55	11.01±4.06	2.19±1.36
After treatment	40	4.74±1.83**	13.42±2.01**	1.52±1.48*

Group	n	anti-TG Ab	anti-TM Ab
RJXYD-treated
Before treatment	40	53.13±11.65	47.65±8.07
After treatment	40	25.67±10.35**^△△	20.49±7.92**^△△
Control
Before treatment	40	52.82±10.93	47.32±7.91
After treatment	40	47.43±11.71*	39.68±9.67**

Effects of Ruanjian Xiaoying Decoction on chronic lymphocytic thyroiditis

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