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Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (1): 11-14.doi: 10.3736/jcim20070103

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Methods of selecting outcome variables for clinical intervention

Xia Wan1,2, Jian-ping Liu2, Hong-wei Zhang2, Yan-ke Ai2   

  1. 1. Institute of Basic Medical Science, Chinese Academy of Medical Sciences, and Department of Epidemiology, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China
    2. Evidence-Based Chinese Medicine Center for Clinical Research and Evaluation, School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China
  • Online:2007-01-31 Published:2007-01-21

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There are two stages for selecting the clinical intervention outcome variables. One is crude collection and the other is precise collection. The selection methods include brainstorming method, Delphi method, Gordon method, systematic review, systematic analysis method, mathematic model method and so on. Each method has some advantages or disadvantages. When selecting the clinical intervention outcome variables, researchers should make sure the research aim, the representative and the sensitivity of the variables, and select all kinds of recommended methods comprehensively, then decide which method should be used.

Key words: clinic studies, intervention studies, outcome assessment, methods

CLC Number: 

  • R-3
[1] 郭新峰, 朱泉, 赖世隆 . 替代指标和中间指标及其在中医药疗效评价研究中应用价值的思考[J]. 中国中西医结合杂志, 2005,25(7):585-590
Guo XF, Zhu Q, Lai SL . Thinking on surrogate outcomes, intermediary outcomes and their application in TCM clinical efficacy evaluation[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 2005,25(7):585-590
[2] 郭新峰, 赖世隆, 梁伟雄 . 中医药临床疗效评价中结局指标的选择与应用[J]. 广州中医药大学学报, 2002,19(4):251-255
Guo XF, Lai SL, Liang WX . Choice and application of the outcome indexes for clinical effectiveness assessment of traditional Chinese medicine[J]. Guangzhou Zhong Yi Yao Da Xue Xue Bao, 2002,19(4):251-255
[3] 王关义.生产管理( 第2版)[M]. 北京: 北京经济管理出版社,2002,(第2版):
Wang GY. Manufacture management(2nd ed)[M]. Beijing: Economic Management Press,2002,(2nd ed):
[4] 曾光 . 现代流行病学方法与应用(第2版)[M]. 北京: 北京医科大学中国协和医科大学联合出版社,1994,(第2版):
Zeng G. Method and application of modern epidemiology(2nd ed)[M]. Beijing: Union Publishing House of Beijing University of Medical Science and Peking Union Medical University,1994,(2nd ed):
[5] .[ 陶翔, 施雯, . 德尔菲法的基本概念. .
[ Tao X, Shi W .Basic concepts of the Delphi method. THER].Tao X, Shi W. Basic concepts of the Delphi method. . Chinese.
[6] . Gordon TJ. . The Delphi method. .
[7] 王吉耀 . 循证医学与临床实践(第2版)[M]. 上海: 上海科学技术出版社,2006,(第2版):
Wang JY . Evidence-based medicine and clinical practice(2nd ed) [M]. Shanghai: Shanghai Scientific and Technical Publishers , 2006,(2nd ed):
[8] 余松林 . 医学统计学(第1版)[M]. 北京: 人民卫生出版社,2003,(第1版):
Yu SL. Medical statistics(1st ed)[M]. Beijing: People's Medical Publishing House,2003,(1st ed):
[9] 金丕焕 . 医用统计方法(第2版)[M]. 上海: 复旦大学出版社,2003,(第2版):
Jing PH. Medical statistical methods(2nd ed)[M]. Shanghai: Fudan University Press,2003,(2nd ed):Chinese
[10] 孙振球 . 医学统计学(第1版)[M]. 北京: 人民卫生出版社,2002,(第1版):
Sun ZQ.Medical statistics( 1st ed ) [M].Beijing: People's Medical Pulblishing House, 2002,( 1st ed):
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