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Journal of Chinese Integrative Medicine ›› 2007, Vol. 5 ›› Issue (4): 378-382.doi: 10.3736/jcim20070404

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Feasibility for inhibiting tumor metastasis with Chinese herbal medicines as angiogenesis inhibitors

Huan-rong Li1,Xiu-rong Li2   

  1. 1. Chinese Journal of Integrated Traditional and Western Medicine Press, Beijing 100091, China
    2. Department of Oncology, Affiliated Hospital, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250011, China
  • Online:2007-07-31 Published:2007-05-15

Anti-angiogenesis is one of the important ways to control tumor growth and metastasis, and searching for anti-angiogenesis herbs targeting tumor angiogenesis has become a hot topic in both basic and clinical research for tumor. Utilizing the traditional Chinese medicine theory, authors of this article discussed the feasibility and research of anti-angiogenesis effect of Chinese medicine on tumor. To develop new drugs inhibiting tumor angiogenesis from the Chinese native herbal medicine has an extremely vital significance in blocking tumor invasion and metastasis, as well as improving the patients' prognosis and their survival rates.

Key words: traditional Chinese medicine, antineoplastic agents, angiogenesis inhibitors, neoplasm metastasis

CLC Number: 

  • R73-37
[1] O'Reilly MS , Holmgren L, Shing OY, et al.Angiostatin, a novel angiogenesis inhibitor that mediates the suppression of metastasis by Leweis lung cancer[J]. Cell, 1994,79(2):315-328
[2] 周俊 . 中药复方——天然组合化学库与多靶作用机理[J]. 中国中西医结合杂志, 1998,18(2):67
Zhou J . Composite recipe of Chinese medicines, the natural combination of chemicals, and mechanism of multi-target action[J]. Zhongguo Zhong Xi Yi Jie He Za Zhi, 1998,18(2):67
[3] 范跃祖, 陈春球, 赵泽明 , 等. 去甲斑蝥素对胆囊癌肿瘤血管生成的作用及机制研究[J]. 中华医学杂志, 2006,86(10):693-699
Fan YZ, Chen CQ, Zhao ZM , et al. Effects of norcantharidin on angiogenesis of human gallbladder carcinoma and its anti-angiogenic mechanisms[J]. Zhonghua Yi Xue Za Zhi, 2006,86(10):693-699
[4] 张妮娜, 卜平, 朱海杭 , 等. 半枝莲抑制肿瘤血管生成的作用及其机制研究[J]. 癌症, 2005,24(12):1459-1463
Zhang NN, Bu P, Zhu HH , et al. Inhibitory effects of Scutellaria barbatae D. Don on tumor angiogenesis and its mechanism[J]. Ai Zheng, 2005,24(12):1459-1463
[5] Wang S, Zheng Z, Weng Y , et al. Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts[J]. Life Sci, 2004,74(20):2467-2478
doi: 10.1016/j.lfs.2003.03.005 pmid: 15010258
[6] 何振辉, 何太平, 莫丽儿 , 等. 白藜芦醇与半边旗二萜类化合物5F对活体血管生成的影响[J]. 实用医技杂志, 2006,13(1):1-3
He ZH, He TP, Mo LE , et al. Effect of resveratrol and the diterperoid compound 5F isolated from Pteris semipinnata L on angiogenesis in vivo[J]. Shi Yong Yi Ji Za Zhi, 2006,13(1):1-3
[7] Brekken RA, Overholser JP, Stastny VA , et al. Selective inhibition of vascular endothelial growth factor(VEGF) receptor 2(KDR/Flk-1) activity by a monoclonal anti-VEGF antibody blocks tumor growth in mice[J]. Cancer Res, 2000,60(18):5117-5124
[8] 颜大海, 朱树林, 付宝忠 . 鸡胚法筛选具有血管生成抑制作用中药[J]. 黑龙江医药, 1998,11(2):94
Yan DH, Zu SL, Fu BZ . Screening of anti-angiogenesis Chinese medicine by chicken embryo[J]. Heilongjiang Yi Yao, 1998,11(2):94
[9] 徐中平, 李福川, 王海仁 . 昆布多糖硫酸酯的抑制血管生成和抗肿瘤作用[J]. 中草药, 1999,30(7):551-553
Xu ZP, Li FC, Wang HR . Functions of laminarin sulphate in anti-angiogenesis and anti-tumor[J]. Zhong Cao Yao, 1999,30(7):551-553
[10] 王志玲 . 饮茶抑制血管生成[J]. 国外医学卫生学分册, 2000,27(3):190
Wang ZL . Drinking tea inhibits angiogenesis[J]. Guo Wai Yi Xue Wei Sheng Xue Fen Ce, 2000,27(3):190
[11] 徐瑞成, 陈小义, 陈莉 , 等. Bufalin抗癌机制研究进展[J]. 国外医学肿瘤学分册, 2000,27(4):202-204
Xu RC, Chen XY, Chen L , et al. Mechanism research progress of bufalin in anti-cancer[J]. Guo Wai Yi Xue Zhong Liu Xue Fen Ce, 2000,27(4):202-204
[12] Shinkai K, Akedo H, Mukai M . Inhibition of in vitro tumor cell invasion by ginsenoside Rg3[J]. Jpn J Cancer Res, 1996,87(4):357-362
[13] Mochizuki M, Yung CY, Kaori M . Inhibition effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-insenoside-Rg3, of red ginseng[J]. Biol Pharm Bull, 1995,18(9):1197-1202
[14] 高勇, 王杰军, 许青 , 等. 人参皂苷Rg3抑制肿瘤新生血管形成的研究[J]. 第二军医大学学报, 2001,22(1):40
Gao Y, Wang JJ, Xu Q , et al. Inhibitory effect of ginsenoside Rg3 on tumor neoangiogenesis[J]. Di Er Jun Yi Da Xue Xue Bao, 2001,22(1):40
[15] 潘子民, 叶大风, 谢幸 , 等. 人参皂苷Rg3对荷卵巢癌的严重联合免疫缺陷鼠的抗肿瘤血管生成作用的研究[J]. 中华妇产科杂志, 2002,37(4):227-230
Pan ZM, Ye DF, Xie X , et al. Antiangiogenesis of ginsenoside Rg3 in severe combined immunodeficient mice with human ovarian carcinoma[J]. Zhonghua Fu Chan Ke Za Zhi, 2002,37(4):227-230
[16] 李大鹏 . 康莱特注射液抗癌作用机理研究进展[J]. 中药新药与临床药理, 2001,12(2):122-124
Li DP . Mechanism research progress of Kanglaite Injection in anti-cancer[J]. Zhong Yao Xin Yao Yu Lin Chuang Yao Li, 2001,12(2):122-124
[17] 姜晓玲, 张良, 徐卓玉 , 等. 薏苡仁注射液对血管生成的影响[J]. 肿瘤, 2000,20(4):313-314
Jiang XL, Zhang L, Xu ZY , et al. The influence of Semen Coicis Injection on angiogenesis[J]. Zhongliu, 2000,20(4):313-314
[18] 高勇, 王杰军, 梅长林 , 等. 红素抑制血管生长的实验研究[J]. 肿瘤, 1998,18(4):280-281
Gao Y, Wang JJ, Mei CL , et al. Experimental research of tripterine in inhibiting angiogenesis[J]. Zhong Liu, 1998,18(4):280-281
[19] 陈世壮, 计磊, 王玉萍 , 等. 红素对大鼠肝脏内皮细胞的体外杀伤作用[J]. 前卫医药杂志, 1999,16(6):337-339
Chen SZ, Ji L, Wang YP , et al. Damaging effect on rat liver endothelial cells of tripterine in vitro[J]. Qian Wei Yi Yao Za Zhi, 1999,16(6):337-339
[20] 陈达理, 张绪慧 . 鳖甲煎丸抗肿瘤血管生成的实验研究[J]. 浙江中医杂志, 2004,39(12):535-537
Chen DL, Zhang XH . Experimental study on anti-angiogenesis in tumor of Biejiajie Pills[J]. Zhejiang Zhong Yi Za Zhi, 2004,39(12):535-537
[21] 刘鲁明, 林胜友 . 参麦注射液对恶性肿瘤化学药物治疗增效减毒作用的临床和实验研究[J]. 中国肿瘤, 1993,2(9):22
Liu LM, Lin SY . Experimental and clinical study on attenuated synergies of chemical medicine by Shenmai Injection[J]. Zhongguo Zhong Liu, 1993,2(9):22
[22] 尹丽慧, 高承贤, 丁志山 , 等. 参麦注射液对牛内皮细胞增殖抑制作用的实验研究[J]. 浙江中医学院学报, 2002,26(2):48-50
Yin LH, Gao CX, Ding ZS , et al. An experimental study on the inhibiting effect of Shenmai Injection on endothelial cell proliferation[J]. Zhejiang Zhong Yi Xue Yuan Xue Bao, 2002,26(2):48-50
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