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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (2): 148-152.doi: 10.3736/jcim20080208

Special Issue: Traditional Chinese Medicine

• Original Clinical Research • Previous Articles     Next Articles

Characteristics of coronary arteriography and traditional Chinese medicine syndrome of 1 069 patients with coronary artery disease

Jie Wang1, Yan-wei Xing1(), Jian-xin Chen2, Qing-yong He1, Yong-hong Gao3, Zun Li1   

  1. 1. Department of Cardiology, Guang^anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China
    2. Key Laboratory of Complex System and Intelligence Science, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, China
    3. Key Laboratory of Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China
  • Received:2007-07-19 Online:2008-02-20 Published:2008-02-15
  • Contact: XING Yan-wei E-mail:xingyanwei12345@163.com

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Objective:To study the characteristics of coronary arteriography and traditional Chinese medicine syndrome of 1 069 patients with coronary artery disease (CAD).

Methods:One thousand and sixty-nine patients with CAD were investigated by epidemiological method. The patients were divided into young patients (n=82, aged 45 years or younger) and middle-aged and old patients (n=987, older than 45 years). The characteristics of the two groups were analyzed, including clinical data, coronary arteriography and traditional Chinese medicine syndrome.

Results:Compared with middle-aged and old patients, proportion of male, triglyceride, total cholesterol, smoking patients, acute myocardial infarction and family history of CAD in young patients were significantly higher (P<0.05). Patients accompanying with hypertension and diabetes in middle-aged and old patients were more than those in young patients (P<0.05). Occurrence rates of morbidity of left circumflex coronary artery, left main coronary artery and multi-branch were higher in middle-aged and old patients (P<0.05), however, the occurrence rates of morbidity of single and doublebranch were higher in young patients (P<0.05). The occurrence rates of syndromes of qi stagnation and phlegm turbidity in young patients were higher than those in middleaged and old patients (P<0.05). But the proportions of cold coagulation, yin deficiency, yang deficiency and kidney deficiency in middle-aged and old patients were obviously higher (P<0.05).

Conclusion:The traditional Chinese medicine syndrome and pathological changes of CAD in young patients are different from those in old patients.

Key words: coronary heart disease, coronary arteriography, symptom complex, youth

CLC Number: 

  • R541.4

Table 1

Clinical data of young patients and middle-aged and old patients with CAD"

Items Young patients(n=82, ≤45 years) Middle-aged and old patients
(n=987, >45 years)		 P
Male [Cases (%)] 76 (93.0) 696 (70.5) 0.00
Age($\bar{x}$±s, year) 40.52±4.38 62.98±9.52 0.00
Blood lipid
TG ($\bar{x}$±s, mmol/L) 2.41±1.54 1.46±0.68 0.00
TC($\bar{x}$±s, mmol/L) 4.73±1.17 4.04±1.02 0.04
HDL($\bar{x}$±s, mmol/L) 1.04±0.83 1.16±0.38 0.96
LDL($\bar{x}$±s, mmol/L) 2.96±1.05 2.66±0.73 0.61
Risk factor
Smoking [Cases (％)] 63 (83) 499 (51) 0.00
HBP [Cases (％)] 34 (41) 636 (64) 0.00
Diabetes [Cases (％)] 8 (10) 247 (25) 0.01
Acute myocardial infarction [Cases (％)] 11 (13) 27 (3) 0.01
Family history [Cases (％)] 28 (34) 117 (12) 0.00

Table 2

Occupation of young and middle aged and old patients with CAD [Cases (％)]"

Group n Civil servant Peasant Staff Driver
Young patients 82 14 (17) 15 (18) 10 (12) 12 (15)
Middle-aged and old patients 987 341 (35) 174 (18) 122 (12) 7 (1)
P 0.00 1 1 0.00

Table 3

Morbidity of coronary artery in young and middle-aged and old patients with CAD [Cases (％)]"

Group n LM LAD LCX RCA Single branch Double branch Multi-branch
Young patients 82 5 (6) 78 (95) 40 (49) 42 (51) 28 (34) 27 (33) 27 (33)
Middle-aged and old patients 987 152 (15) 907 (92) 702 (71) 624 (63) 131 (12) 141 (14) 715 (72)
P 0.03 0.87 0.03 0.08 0.01 0.01 0.00

Table 4

Traditional Chinese medicine syndrome distribution in young and middle-aged and old patients with CAD [Cases (％)]"

Syndrome Young patients (n=82) Middle-aged and old patients (n=987) P
Qi stagnation 18 (22) 109 (11) 0.03
Blood stasis 54 (66) 663 (67) 0.98
Phlegm turbidity 40 (49) 330 (33) 0.04
Cold coagulation 0 (0) 25 (3) 0.04
Heat accumulation 17 (21) 123 (13) 0.13
Qi deficiency 52 (63) 683 (69) 0.87
Yin deficiency 22 (27) 383 (39) 0.04
Yang deficiency 6 (7) 198 (20) 0.01
Heart deficiency 3 (4) 100 (10) 0.09
Liver deficiency 8 (10) 119 (12) 0.77
Spleen deficiency 5 (6) 71 (7) 0.98
Kidney deficiency 12 (15) 311 (32) 0.01
Lung deficiency 8 (10) 60 (6) 0.21
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