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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (8): 783-787.doi: 10.3736/jcim20080803

• Original Clinical Research • Previous Articles     Next Articles

Laws of compound traditional Chinese medicine in treatment of dysmenorrhea

Jian-li Ni1(), Pan Zhang2, Fu-yao Ren2   

  1. 1. Department of Traditional Chinese Medicine, Xinhua Hospital, Medical Collage, Shanghai Jiao tong University, Shanghai 200092, China
    2. Department of Mathematics, Fudan University, Shanghai 200433, China
  • Received:2008-03-07 Online:2008-08-20 Published:2008-08-15

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Compound traditional Chinese medicine database was established by collecting 176 compound formulas for dysmenorrhea in the last twenty years. The proportion and frequency of herbal medicine were analysed and the main herbs with mono-target or multi-target in the compound formulas were selected with simple and multiple linear regression. The linear regression equations were listed and the clinical effects of the compound formulas were evaluated. Of 173 herbs used in the compound formulas, the proportion and frequency of the herbs for activating blood and transforming stasis and regulating qi flow were high in the application. The dosage interval for 20 herbs in common use was estimated. Main herbs with mono-target or multi-target used in the compound formulas were selected with simple and multiple linear regression. The total effectiveness rate of the 176 compound formulas was tested with simple linear regression, and 167 compound formulas (94.84 % of the total) had the absolute error less than 4%. Herbs for activating blood and transforming stasis and regulating qi flow are most commonly used in treatment of dysmenorrhea. Clinical effects of the compound formulas could be forecast with stepwise regression equation.

Key words: dysmenorrhea, Chinese herbal drugs, compounds (traditional Chinese drugs), regression analysis

CLC Number: 

  • R271.113

"

药物归类 药物的使用比例（%） 药物的使用频率（%）
活血化瘀药（18种） 10.40 39.24
理气药（19种） 10.98 19.02
温经散寒药（11种） 6.36 9.92

"

序号 药对 使用次数 使用频率 (%)
1 当归和川芎* 60 34.09
2 三棱和莪术* 54 30.68
3 蒲黄和五灵脂* 49 27.84
4 乳香和没药* 32 18.18
5 桃仁和红花* 25 14.20
6 黄芪和当归 19 10.80
7 丹参和桃仁* 17 9.66
8 白芍和甘草 14 7.95
9 青皮和陈皮 2 1.14
10 羌活和独活 2 1.14
11 全蝎和蜈蚣 2 1.14
12 女贞子和旱莲草 1 0.57

"

序号 中药 最大剂量（g） 最小剂量（g） 平均剂量（g） 使用次数 使用频率 (%)
1 当归 30 6 12.46 102 57.95
2 延胡索* 30 6 11.99 94 53.41
3 莪术* 30 5 10.47 74 42.05
4 川芎* 20 5 10.44 70 39.77
5 赤芍 30 6 11.71 68 38.64
6 五灵脂* 20 3 10.44 64 36.36
7 三棱* 30 3 10.39 62 35.23
8 蒲黄* 30 6 11.13 61 34.66
9 香附△ 40 3 11.10 60 34.09
10 丹参* 40 4.5 16.01 60 34.09
11 桃仁* 20 5 10.26 46 26.14
12 没药* 15 3 9.00 44 25.00
13 甘草 10 3 6.83 43 24.43
14 红花* 15 5 9.43 40 22.73
15 白芍 30 6 14.38 37 21.02
16 乳香* 15 3 8.58 36 20.45
17 乌药△ 15 2 5.93 35 19.89
18 肉桂▲ 15 3 9.23 35 19.89
19 丹皮 15 4.5 9.92 33 18.75
20 小茴香▲ 15 3 8.95 29 16.48

"

误差 百分比（%）
最大误差 9.84
最小误差 0.000 2
平均误差 1.76
标准误差 2.24

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|Δy| (%) 中药复方数 占复方总数的比例 (%)
[0,1] 67 38.07
[1,2] 50 28.41
[2,3] 28 15.91
[3,4] 22 12.5
[4,10] 9 5.11
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