[an error occurred while processing this directive]

Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (9): 952-955.doi: 10.3736/jcim20080915

• Original Experimental Research • Previous Articles     Next Articles

Effects of Rhodiola rosea on body weight and intake of sucrose and water in depressive rats induced by chronic mild stress

Qiao-ge Chen, Yuan-shan Zeng(), Jiu-yu Tang, Ya-jing Qin, Sui-jun Chen, Zhi-qiang Zhong   

  1. Division of Neuroscience, Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China
  • Received:2008-01-25 Online:2008-09-20 Published:2008-09-15

RichHTML

6

PDF (PC)

73

Cited

12

Like

Objective: To explore the effects of Rhodiola rosea on the body weight and the intake of sucrose and water in depressive rats induced by chronic mild stress.
Methods: A total of 70 male SD rats were divided into seven groups, including normal control group (treated with 0.5% sodium carboxymethycellulose), untreated group, negative control group (treated with 0.5% sodium carboxymethycellulose), positive control group (treated with fluoxetine), low-, medium- and high-dose Rhodiola rosea group (treated with 1.5, 3, 6 g/kg Rhodiola rosea respectively). Except for rats in normal control group, the other sixty rats endured chronic stress for 4 weeks to establish the depression model. After that, rats were administered Rhodiola rosea for 3 weeks. During the whole experiment, the body weight, and sucrose intake, tap water intake of all rats were examined once a week.
Results: After the termination of the stress regime, compared with the normal control group, the body weight and 1% sucrose intake in depressive rats were decreased. After 3-week Rhodiola rosea treatment, the body weight and 1% sucrose intake increased in rats of the low-dose Rhodiola rosea group and recovered to the level of the normal control group.
Conclusion: Low-dose Rhodiola rosea can increase the body weight and sucrose intake of depressive rats, making them recover to normal status.

Key words: chronic mild stress, depression, Rhodiola rosea, body weight, behaviors

CLC Number: 

  • R749

Table 1

Changes of the body weight of rats in seven groups after intragastric administration (x±s, g)"

Group n Body weight
4th week 5th week 6th week 7th week
Normal control 10 313±8.0 326±8.0 345±9.0 358±6.0
Untreated 10 304±13.0* 314±14.0* 333±12.0* 348±12.0*
Negative control 10 301±8.0* 309±8.0* 329±7.0* 349±6.0*
Positive control 10 303±7.0* 320±8.0 342±10.0* 362±10.0
Low-dose Rhodiola rosea 10 303±8.0* 324±7.0 339±7.0* 367±8.0△
Medium-dose Rhodiola rosea 10 305±9.0* 325±4.0 349±6.0 364±9.0△
High-dose Rhodiola rosea 10 305±7.0* 328±7.0 344±6.0 360±6.0△

Table 2

Changes of the sucrose intake of rats in seven groups after intragastric administration (x±s, g)"

Group n Sucrose intake
4th week 5th week 6th week 7th week
Normal control 10 11.8±2.2 12.5±0.9 13.8±1.0 15.5±1.6
Untreated 10 7.4±0.9* 9.1±0.9* 10.8±1.3* 12.1±0.9*
Negative control 10 8.2±1.1* 9.8±1.2* 10.8±1.0* 11.9±0.8*
Positive control 10 7.7±0.8* 11.6±0.9* 13.4±0.7 14.8±1.2
Low-dose Rhodiola rosea 10 7.4±0.7* 9.4±0.6* 12.3±1.0* 15.4±1.1△
Medium-dose Rhodiola rosea 10 7.2±0.7* 9.9±1.3* 12.3±1.0* 13.3±1.0*△▲
High-dose Rhodiola rosea 10 7.2±0.8* 8.4±1.3* 9.3±0.6* 12.3±1.1*△▲
[1] Wang Y, Chen SD . Progress of the treatment of depression[J]. Shi Jie Lin Chuang Yao Wu, 2005,26(3):164-167
王瑛, 陈生弟 . 抑郁症治疗进展[J]. 世界临床药物, 2005,26(3):164-167
[2] Bai HX, Dai CM, Liu XF , et al. Overview of traditional Chinese medicine in treating depressive disorder[J]. Shaanxi Zhong Yi Xue Yuan Xue Bao, 2005,28(2):65-66
白海侠, 戴常梅, 刘西纺 , 等. 中医治疗抑郁症的概况[J]. 陕西中医学院学报, 2005,28(2):65-66
[3] Qu ZW . Progress of the Rhodiola herb[J]. Zhonghua Shi Yong Zhong Xi Yi Za Zhi, 2005,18(7):1063-1066
曲智威 . 红景天的研究进展[J]. 中华实用中西医杂志, 2005,18(7):1063-1066
[4] Willner P . The validity of animal models of depression[J]. Psychopharmacology (Berl), 1984,83(1):1-16
doi: 10.1007/BF00427414 pmid: 6429692
[5] Willner P, Moreau JL, Nielsen CK , et al. Decreased hedonic responsiveness following chronic mild stress is not secondary to loss of body weight[J]. Physiol Behav, 1996,60(1):129-134
doi: 10.1016/0031-9384(95)02256-2
[6] Willner P, Towell A, Sampson D , et al. Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant[J]. Psychopharmacology (Berl), 1987,93(3):358-364
[7] Muscat R, Willner P . Suppression of sucrose drinking by chronic mild unpredictable stress: a methodological analysis[J]. Neurosci Biobehav Rev, 1992,16(4):507-517
doi: 10.1016/S0149-7634(05)80192-7 pmid: 1480347
[8] Perfumi M, Mattioli L . Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice[J]. Phytother Res, 2007,21(1):37-43
doi: 10.1002/(ISSN)1099-1573
[9] Panossian A, Wagner H . Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration[J]. Phytother Res, 2005,19(10):819-838
doi: 10.1002/(ISSN)1099-1573
[1] Karuna A. Talpate, Uma A. Bhosale, Mandar R. Zambare. Clitorea ternatea, a herb from Indian folklore, improves streptozotocin-induced diabetes and diabetes-induced cognitive decline in rats. Journal of Chinese Integrative Medicine, 2012, 10(8): 939-947.
[2] Sui Yue Hu, Su E Wang, Chun Hu Zhang. Relationship between symptom stratification and syndrome differentiation of traditional Chinese medicine for depressive episode. Journal of Chinese Integrative Medicine, 2011, 9(9): 933-936.
[3] Yan-bo Zhu, Qi Wang, Ke-fan Chen, Yu-e Wu, Wei-li Hong, Li Liu. Stratified analysis of the relationship between traditional Chinese medicine constitutional types and health status in the general population based on data of 8448 cases. Journal of Chinese Integrative Medicine, 2011, 9(4): 382-389.
[4] Cai Lin-lin, Li Hao, Liu Jian-gang, Liu Long-tao, Guan Jie, Liu Ming-fang, Hu Jia, Wei Yun. Effects of early intervention with Huannao Yicong formula effective components on behavior and cholinergic system of β-amyloid precursor protein transgenic mice. Journal of Chinese Integrative Medicine, 2011, 9(3): 292-298.
[5] Hui Han, Li-min Wu, Wen-ming Yang, Mei-xia Wang, Jing-jing Tang, Han Wang, Zhi-xiu Liu, Rong-zhi Liu, Ting Dong, Juan Zhang , Bo Yang, Ming-xiang Han. Characteristics of traditional Chinese medicine syndromes in post-stroke depression. Journal of Chinese Integrative Medicine, 2010, 8(5): 427-431.
[6] Li-juan Xiu, Pin-kang Wei, Hui-ming Lin, Bin Pang. Effects of Xiaotan Jieyu Recipe on behaviors of tumor-bearing rats with chronic mild stress and the mechanism. Journal of Chinese Integrative Medicine, 2010, 8(2): 138-144.
[7] Xin-jun Wang, Ling-ling Wang . A mechanism of endogenous opioid peptides for rapid onset of acupuncture effect in treatment of depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1014-1017.
[8] Tao Wang , Feng Qin. Effects of Chinese herbal medicine Xiaoyao Powder on monoamine neurotransmitters in hippocampus of rats with postpartum depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1075-1079.
[9] Yan-bo Zhu , Qi Wang, Cheng-yu Wu, Guo-ming Pang, Jian-xiong Zhao, Shi-lin Shen, Zhong-yuan Xia , Xue Yan . Logistic regression analysis on relationships between traditional Chinese medicine constitutional types and overweight or obesity. Journal of Chinese Integrative Medicine, 2010, 8(11): 1023-1035.
[10] Jin Zheng, Ji Li, Li Zhang , Guo-hua Hu, Chao-qin Yu, Zhao-fen Zhang, Shuang Ni, Mei-juan Wei. Epidemiological investigation of perimenopausal women in Shanghai. Journal of Chinese Integrative Medicine, 2009, 7(9): 827-830.
[11] Chun Zhang , Lin Li, Yun Jiang. Psychotherapy and traditional Chinese medicine for perimenopausal depression: A literature review. Journal of Chinese Integrative Medicine, 2009, 7(8): 779-783.
[12] Xiu-fang Gao, Hai-ming Shi, Tao Sun, Hong Ao. Effects of Radix et Rhizoma Rhodiolae Kirilowii on expressions of von Willebrand factor, hypoxia-inducible factor 1 and vascular endothelial growth factor in myocardium of rats with acute myocardial infarction. Journal of Chinese Integrative Medicine, 2009, 7(5): 434-440.
[13] Li Ma, Dong-lian Cai, Huai-xing Li, Ben-de Tong, Ying Wang, Su-ping Pei. Protective effects of salidroside on oxidative damage in fatigue mice. Journal of Chinese Integrative Medicine, 2009, 7(3): 237-241.
[14] Yi-qing Zou, Zhi-yang Cai, Yan-fei Mao , Jin-bao Li , Xiao-ming Deng . Effects of salidroside-pretreatment on neuroethology of rats after global cerebral ischemia-reperfusion. Journal of Chinese Integrative Medicine, 2009, 7(2): 130-134.
[15] Yun-hui Li, Chun-hu Zhang, Su-e Wang, Juan Qiu, Sui-yu Hu, Gui-lin Xiao. Effects of Chaihu Shugan San on behavior and plasma levels of corticotropin releasing hormone and adrenocorticotropic hormone of rats with chronic mild unpredicted stress depression. Journal of Chinese Integrative Medicine, 2009, 7(11): 1073-1077.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] Wei-xiong Liang. Problems-solving strategies in clinical treatment guideline for traditional Chinese medicine and integrative medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 1-4
[2] Zhao-guo Li. Discussion on English translation of commonly used sentences in traditional Chinese medicine: part one. Journal of Chinese Integrative Medicine, 2008, 6(1): 107-110
[3] Jun Hu, Jian-ping Liu. Non-invasive physical treatments for chronic/recurrent headache. Journal of Chinese Integrative Medicine, 2008, 6(1): 31
[4] Xue-mei Liu, Qi-fu Huang, Yun-ling Zhang, Jin-li Lou, Hong-sheng Liu, Hong Zheng. Effects of Tribulus terrestris L. saponion on apoptosis of cortical neurons induced by hypoxia-reoxygenation in rats. Journal of Chinese Integrative Medicine, 2008, 6(1): 45-50
[5] . Uniform requirements for manuscripts submitted to biomedical journals: Writing and editing for biomedical publication (Chinese version, part two). Journal of Chinese Integrative Medicine, 2010, 8(11): 1001-1005
[6] Daniel Weber, Janelle M Wheat, Geoffrey M Currie. Inflammation and cancer: Tumor initiation, progression and metastasis,and Chinese botanical medicines. Journal of Chinese Integrative Medicine, 2010, 8(11): 1006-1013
[7] Hong Liu , Guo-liang Zhang, Li Shen , Zhen Zeng, Bao-luo Zhou, Cheng-hai Liu, Guang Nie . Application and evaluation of a pseudotyped virus assay for screening herbs for anti-H5Nl avian influenza virus. Journal of Chinese Integrative Medicine, 2010, 8(11): 1036-1040
[8] Zhao-guo Li . A discussion of English translation of 1995 and 1997 Chinese National Standards of Traditional Chinese Medical Terminologies for Clinical Diagnosis and Treatment. Journal of Chinese Integrative Medicine, 2010, 8(11): 1090-1096
[9] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[10] Hui-min Liu, Xian-bo Wang, Yu-juan Chang, Li-li Gu. Systematic review and meta-analysis of randomized controlled trials of integrative medicine therapy for treatment of chronic severe hepatitis. Journal of Chinese Integrative Medicine, 2012, 10(11): 1211-1228
[an error occurred while processing this directive]