Search JIM Advanced Search

Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (9): 952-955.doi: 10.3736/jcim20080915

• Original Experimental Research • Previous Articles     Next Articles

Effects of Rhodiola rosea on body weight and intake of sucrose and water in depressive rats induced by chronic mild stress

Qiao-ge Chen, Yuan-shan Zeng(), Jiu-yu Tang, Ya-jing Qin, Sui-jun Chen, Zhi-qiang Zhong   

  1. Division of Neuroscience, Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province 510080, China
  • Received:2008-01-25 Online:2008-09-20 Published:2008-09-15

Objective: To explore the effects of Rhodiola rosea on the body weight and the intake of sucrose and water in depressive rats induced by chronic mild stress.
Methods: A total of 70 male SD rats were divided into seven groups, including normal control group (treated with 0.5% sodium carboxymethycellulose), untreated group, negative control group (treated with 0.5% sodium carboxymethycellulose), positive control group (treated with fluoxetine), low-, medium- and high-dose Rhodiola rosea group (treated with 1.5, 3, 6 g/kg Rhodiola rosea respectively). Except for rats in normal control group, the other sixty rats endured chronic stress for 4 weeks to establish the depression model. After that, rats were administered Rhodiola rosea for 3 weeks. During the whole experiment, the body weight, and sucrose intake, tap water intake of all rats were examined once a week.
Results: After the termination of the stress regime, compared with the normal control group, the body weight and 1% sucrose intake in depressive rats were decreased. After 3-week Rhodiola rosea treatment, the body weight and 1% sucrose intake increased in rats of the low-dose Rhodiola rosea group and recovered to the level of the normal control group.
Conclusion: Low-dose Rhodiola rosea can increase the body weight and sucrose intake of depressive rats, making them recover to normal status.

Key words: chronic mild stress, depression, Rhodiola rosea, body weight, behaviors

CLC Number: 

  • R749

Table 1

Changes of the body weight of rats in seven groups after intragastric administration (x±s, g)"

Group n Body weight
4th week 5th week 6th week 7th week
Normal control 10 313±8.0 326±8.0 345±9.0 358±6.0
Untreated 10 304±13.0* 314±14.0* 333±12.0* 348±12.0*
Negative control 10 301±8.0* 309±8.0* 329±7.0* 349±6.0*
Positive control 10 303±7.0* 320±8.0 342±10.0* 362±10.0
Low-dose Rhodiola rosea 10 303±8.0* 324±7.0 339±7.0* 367±8.0
Medium-dose Rhodiola rosea 10 305±9.0* 325±4.0 349±6.0 364±9.0
High-dose Rhodiola rosea 10 305±7.0* 328±7.0 344±6.0 360±6.0

Table 2

Changes of the sucrose intake of rats in seven groups after intragastric administration (x±s, g)"

Group n Sucrose intake
4th week 5th week 6th week 7th week
Normal control 10 11.8±2.2 12.5±0.9 13.8±1.0 15.5±1.6
Untreated 10 7.4±0.9* 9.1±0.9* 10.8±1.3* 12.1±0.9*
Negative control 10 8.2±1.1* 9.8±1.2* 10.8±1.0* 11.9±0.8*
Positive control 10 7.7±0.8* 11.6±0.9* 13.4±0.7 14.8±1.2
Low-dose Rhodiola rosea 10 7.4±0.7* 9.4±0.6* 12.3±1.0* 15.4±1.1
Medium-dose Rhodiola rosea 10 7.2±0.7* 9.9±1.3* 12.3±1.0* 13.3±1.0*△▲
High-dose Rhodiola rosea 10 7.2±0.8* 8.4±1.3* 9.3±0.6* 12.3±1.1*△▲
[1] Wang Y, Chen SD . Progress of the treatment of depression[J]. Shi Jie Lin Chuang Yao Wu, 2005,26(3):164-167
王瑛, 陈生弟 . 抑郁症治疗进展[J]. 世界临床药物, 2005,26(3):164-167
[2] Bai HX, Dai CM, Liu XF , et al. Overview of traditional Chinese medicine in treating depressive disorder[J]. Shaanxi Zhong Yi Xue Yuan Xue Bao, 2005,28(2):65-66
白海侠, 戴常梅, 刘西纺 , 等. 中医治疗抑郁症的概况[J]. 陕西中医学院学报, 2005,28(2):65-66
[3] Qu ZW . Progress of the Rhodiola herb[J]. Zhonghua Shi Yong Zhong Xi Yi Za Zhi, 2005,18(7):1063-1066
曲智威 . 红景天的研究进展[J]. 中华实用中西医杂志, 2005,18(7):1063-1066
[4] Willner P . The validity of animal models of depression[J]. Psychopharmacology (Berl), 1984,83(1):1-16
doi: 10.1007/BF00427414 pmid: 6429692
[5] Willner P, Moreau JL, Nielsen CK , et al. Decreased hedonic responsiveness following chronic mild stress is not secondary to loss of body weight[J]. Physiol Behav, 1996,60(1):129-134
doi: 10.1016/0031-9384(95)02256-2
[6] Willner P, Towell A, Sampson D , et al. Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant[J]. Psychopharmacology (Berl), 1987,93(3):358-364
[7] Muscat R, Willner P . Suppression of sucrose drinking by chronic mild unpredictable stress: a methodological analysis[J]. Neurosci Biobehav Rev, 1992,16(4):507-517
doi: 10.1016/S0149-7634(05)80192-7 pmid: 1480347
[8] Perfumi M, Mattioli L . Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice[J]. Phytother Res, 2007,21(1):37-43
doi: 10.1002/(ISSN)1099-1573
[9] Panossian A, Wagner H . Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration[J]. Phytother Res, 2005,19(10):819-838
doi: 10.1002/(ISSN)1099-1573
[1] Bosch Peggy, van den Noort Maurits, Yeo Sujung, Lim Sabina, Coenen Anton, van Luijtelaar Gilles. The effect of acupuncture on mood and working memory in patients with depression and schizophrenia. Journal of Integrative Medicine, 2015, 13(6): 380-390.
[2] Sheng Wei, Jin-liang Hou, Yu-bin Chao, Xi-yang Du, Shao-bo Zong . Analysis on content of serum monoamine neurotransmitters in macaques with anger-in-induced premenstrual syndrome and liver-qi depression syndrome. Journal of Chinese Integrative Medicine, 2012, 10(8): 925-931.
[3] Li Xiao-hong, Li Jing-jing, Liu Yue-yun, Chen Jia-xu. Central neurobiological mechanism of liver depression and spleen deficiency syndrome based on chronic stress: a review. Journal of Chinese Integrative Medicine, 2012, 10(1): 1-6.
[4] Sui Yue Hu, Su E Wang, Chun Hu Zhang. Relationship between symptom stratification and syndrome differentiation of traditional Chinese medicine for depressive episode. Journal of Chinese Integrative Medicine, 2011, 9(9): 933-936.
[5] Hui Han, Li-min Wu, Wen-ming Yang, Mei-xia Wang, Jing-jing Tang, Han Wang, Zhi-xiu Liu, Rong-zhi Liu, Ting Dong, Juan Zhang , Bo Yang, Ming-xiang Han. Characteristics of traditional Chinese medicine syndromes in post-stroke depression. Journal of Chinese Integrative Medicine, 2010, 8(5): 427-431.
[6] Li-juan Xiu, Pin-kang Wei, Hui-ming Lin, Bin Pang. Effects of Xiaotan Jieyu Recipe on behaviors of tumor-bearing rats with chronic mild stress and the mechanism. Journal of Chinese Integrative Medicine, 2010, 8(2): 138-144.
[7] Xin-jun Wang, Ling-ling Wang . A mechanism of endogenous opioid peptides for rapid onset of acupuncture effect in treatment of depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1014-1017.
[8] Tao Wang , Feng Qin. Effects of Chinese herbal medicine Xiaoyao Powder on monoamine neurotransmitters in hippocampus of rats with postpartum depression. Journal of Chinese Integrative Medicine, 2010, 8(11): 1075-1079.
[9] Xing-juan Wang, Ji Li, Qin-di Zou, Ling Jin. Wuling Capsule for climacteric patients with depression and anxiety state: A randomized, positive parallel controlled trial. Journal of Chinese Integrative Medicine, 2009, 7(11): 1042-1046.
[10] Yun-hui Li, Chun-hu Zhang, Su-e Wang, Juan Qiu, Sui-yu Hu, Gui-lin Xiao. Effects of Chaihu Shugan San on behavior and plasma levels of corticotropin releasing hormone and adrenocorticotropic hormone of rats with chronic mild unpredicted stress depression. Journal of Chinese Integrative Medicine, 2009, 7(11): 1073-1077.
[11] A-gao Zhou, Yong Zhang, Gang Kui, De-Yun Kong, Hai-liang Ge, Qiu-hua Ren, Jia-rong Dong, Sheng Hong, Xu-ming Mao, Yin Wang, Hui-zheng Zhang, Shu-jun Wang. Influence of traditional Chinese compound recipes with different efficacy on body weight, tumor weight and immune function in H22 cancer-bearing mice. Journal of Chinese Integrative Medicine, 2008, 6(1): 77-82.
[12] Mu-rong Liu, Ting Han, Yao Chen, Lu-ping Qin, Han-chen Zheng, Yao-cheng Rui. Effect of madecassoside on depression behavior of mice and activities of MAO in different brain regions of rats. Journal of Chinese Integrative Medicine, 2004, 2(6): 440-444.
[13] Bei-lei Feng, Qiao-chu Wang, Zheng-yuan Li. Influence of Jieyu Huoxue Decoction on rehabilitation of patients with depression after cerebral infarction. Journal of Chinese Integrative Medicine, 2004, 2(3): 182-184.
[14] De-po Yang, Liang-chun Gan, Hai-yan Hu. Discussion on clinical efficacy of Hypericum perforatum for depression abroad. Journal of Chinese Integrative Medicine, 2004, 2(3): 231-234.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] Jin-zhou Tian, Jing Shi, Xin-qing Zhang, Qi Bi, Xin Ma, Zhi-liang Wang, Xiao-bin Li, Shu-li Shen, Lin Li, Zhen-yun Wu, Li-yan Fang, Xiao-dong Zhao, Ying-chun Miao, Peng-wen Wang, Ying Ren, Jun-xiang Yin, Yong-yan Wang, Beijing United Study Group on MCI of the Capital Foundation of Medical Developments. An explanation on "guiding principles of clinical research on mild cognitive impairment (protocol)". Journal of Chinese Integrative Medicine, 2008, 6(1): 15-21
[2] Dong Yang, Yong-ping Du, Qing Shen, Wei Chen, Yan Yu, Guang-lei Chen. Expression of alpha-smooth muscle actin in renal tubulointerstitium in patients with kidney collateral stasis. Journal of Chinese Integrative Medicine, 2008, 6(1): 41-44
[3] Zhi-chun Jin. Problems in establishing clinical guideline for integrated traditional Chinese and Western medicine. Journal of Chinese Integrative Medicine, 2008, 6(1): 5-8
[4] SUN Ming-yu, ZUO Jian, DUAN Ji-feng, HAN Jun, FAN Shi-ming, ZHANG Wei, ZHU Li-fang, YAO Ming-hui. Antitumor activities of kushen flavonoids in vivo and in vitro. Journal of Chinese Integrative Medicine, 2008, 6(1): 51-59
[5] Min Cheng, Qiong Feng, Shu-wen Qian, Hui Gao, Cui-qing Zhu. Preliminary assay of p-amyloid binding elements in heart-beneficial recipe. Journal of Chinese Integrative Medicine, 2008, 6(1): 68-72
[6] Hai-feng Wei, Bai-liu Ya, Ling Zhao, Cui-fei Ye, Li Zhang, Lin Li. Evaluation of tongue manifestation of blood stasis syndrome and its relationship with blood rheological disorder in a rat model of transient brain ischemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 73-76
[7] Li Zhou, Hong-xing Zhang, Ling-guang Liu, Wen-jun Wan. Effect of electro-acupuncture at Fenglong (GV 16) on nitric oxide and endothelin in rats with hyperlipidemia. Journal of Chinese Integrative Medicine, 2008, 6(1): 89-92
[8] Rui Jin, Bing Zhang. A complexity analysis of Chinese herbal property theory: the multiple formations of herbal property (Part 1). Journal of Chinese Integrative Medicine, 2012, 10(11): 1198-1205
[9] Liang-ping Hu, Xiao-lei Bao. Three-factor designs unable to examine the interactions (Part 2). Journal of Chinese Integrative Medicine, 2012, 10(11): 1229-1232
[10] Pedro Saganha João, Doenitz Christoph, Greten Tobias, Efferth Thomas, J. Greten Henry. Qigong therapy for physiotherapists suffering from burnout: a preliminary study. Journal of Chinese Integrative Medicine, 2012, 10(11): 1233-1239