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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (12): 1211-1216.doi: 10.3736/jcim20081201

Special Issue: Acupuncture & Moxibustion

• Review •     Next Articles

Acupuncture intervention combined with assisted reproductive technology: its different effects at different time points during the in vitro fertilization-embryo transfer course

Jia Guo1(), Dong Li1, Qiu-fang Zhang2   

  1. 1. Department of Traditional Chinese Medicine and Acupuncture, Peking University Third Hospital, Beijing 100191, China
    2. Medical Reproductive Center, Peking University, Beijing 100191, China
  • Received:2008-06-16 Online:2008-12-20 Published:2008-12-15

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Recently the combination of acupuncture with assisted reproductive technology (ART) to increase the outcomes of ART is being widely studied. In this article, the literatures concerning random controlled clinical trials since 2002 are reviewed and the designs of the trials, especially the timing of acupuncture, are evaluated. Over the past 5 years, the related clinical trials have primarily showed that acupuncture done immediately before and after embryo transfer might increase the assisted reproduction rates, but still requiring further high quality trials with large samples; in addition, different stimulation modes could produce different result, and so far there has not been a consensus as to the optimal time-point for the acupuncture intervention during the in vitro fertilization-embryo transfer (IVF-ET) course. Since the effects of acupuncture change with women's endocrine cycles, it is important and possible to make a breakthrough in ART outcomes if acupuncture is performed at a suitable time point during the cycle of IVF/ET combined with ART.

Key words: acupuncture, acupuncture effects, reproductive techniques, assisted, fertilization in vitro, embryo transfer

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研究者 针刺时间 结果
Paulus等[1] ET前后 CPR ↑*
张明敏等[2] ET前后 CPR ↑*
Magarelli等[3] ET前后 CPR ↑*, 出生率 ↑*, 异位妊娠率↓*, 流产率 ↓*
Westergaard等[4] ET前后, ET后2 d仅针刺2组 针刺1组CPR↑*, OPR↑*; 针刺2组CPR↑, OPR↑
Dieterle等[5] ET后即刻, ET后3 d CPR↑*, OPR↑*
Khorram等[6] ET前5~7 d针刺一次, ET前后 CPR–, 流产率↓*
崔薇等[7] 月经净后2 d至取卵日, 每天针刺一次 受精率↑*, 优质胚胎率↑*, CPR↑
Benson等[8] ET前后 CPR ↑
Teshima等[9] ET前后 CPR↑
Smith等[10] HCG注射当天, ET前后 CPR ↑, OPR↑
Udoff等[11] Gn 刺激前, 取卵前, ET前后 生化怀孕率↑*, OPR↑, 活婴率↑
Lehl等[12] ET前后 OPR–, IR–
Domar等[13] ET前后 CPR–
Stener-Victorin 等[14] 取卵麻醉时 IR–, CPR–, OPR–
Wang等[15] 从月经第5天起每周针灸2次直到黄体期,移植当天除外 CPR–, OPR–
Craig等[16] ET前后 CPR↓*
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