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Journal of Chinese Integrative Medicine ›› 2008, Vol. 6 ›› Issue (12): 1211-1216.doi: 10.3736/jcim20081201

Special Issue: Acupuncture & Moxibustion

• Review •     Next Articles

Acupuncture intervention combined with assisted reproductive technology: its different effects at different time points during the in vitro fertilization-embryo transfer course

Jia Guo1(), Dong Li1, Qiu-fang Zhang2   

  1. 1. Department of Traditional Chinese Medicine and Acupuncture, Peking University Third Hospital, Beijing 100191, China
    2. Medical Reproductive Center, Peking University, Beijing 100191, China
  • Received:2008-06-16 Online:2008-12-20 Published:2008-12-15

Recently the combination of acupuncture with assisted reproductive technology (ART) to increase the outcomes of ART is being widely studied. In this article, the literatures concerning random controlled clinical trials since 2002 are reviewed and the designs of the trials, especially the timing of acupuncture, are evaluated. Over the past 5 years, the related clinical trials have primarily showed that acupuncture done immediately before and after embryo transfer might increase the assisted reproduction rates, but still requiring further high quality trials with large samples; in addition, different stimulation modes could produce different result, and so far there has not been a consensus as to the optimal time-point for the acupuncture intervention during the in vitro fertilization-embryo transfer (IVF-ET) course. Since the effects of acupuncture change with women's endocrine cycles, it is important and possible to make a breakthrough in ART outcomes if acupuncture is performed at a suitable time point during the cycle of IVF/ET combined with ART.

Key words: acupuncture, acupuncture effects, reproductive techniques, assisted, fertilization in vitro, embryo transfer

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研究者 针刺时间 结果
Paulus等[1] ET前后 CPR ↑*
张明敏等[2] ET前后 CPR ↑*
Magarelli等[3] ET前后 CPR ↑*, 出生率 ↑*, 异位妊娠率↓*, 流产率 ↓*
Westergaard等[4] ET前后, ET后2 d仅针刺2组 针刺1组CPR↑*, OPR↑*; 针刺2组CPR↑, OPR↑
Dieterle等[5] ET后即刻, ET后3 d CPR↑*, OPR↑*
Khorram等[6] ET前5~7 d针刺一次, ET前后 CPR–, 流产率↓*
崔薇等[7] 月经净后2 d至取卵日, 每天针刺一次 受精率↑*, 优质胚胎率↑*, CPR↑
Benson等[8] ET前后 CPR ↑
Teshima等[9] ET前后 CPR↑
Smith等[10] HCG注射当天, ET前后 CPR ↑, OPR↑
Udoff等[11] Gn 刺激前, 取卵前, ET前后 生化怀孕率↑*, OPR↑, 活婴率↑
Lehl等[12] ET前后 OPR–, IR–
Domar等[13] ET前后 CPR–
Stener-Victorin 等[14] 取卵麻醉时 IR–, CPR–, OPR–
Wang等[15] 从月经第5天起每周针灸2次直到黄体期,移植当天除外 CPR–, OPR–
Craig等[16] ET前后 CPR↓*
[1] Paulus WE, Zhang M, Strehler E , et al. Influence of acupuncture on the pregnancy rate in patients who undergoing assisted reproduction therapy[J]. Fertil Steril, 2002,77(4):721-724
doi: 10.1016/S0015-0282(01)03273-3
[2] Zhang MM, Huang GY, Lu FE , et al. Effect of acupuncture on pregnancy rate in embryo transfer and mechanism: a randomized and control study[J]. Zhongguo Zhen Jiu, 2003,23(1):3-5
张明敏, 黄光英, 陆付耳 , 等. 针刺对胚胎移植率的影响和机理: 随机安慰对照研究[J]. 中国针灸, 2003,23(1):3-5
[3] Magarelli PC, Cridennda D, Cohen M . Acupuncture: impact on eggs & embryos of IVF patients[J]. Fertil Steril, 2005,83(5 Suppl 1):S9
[4] Westergaard LG, Mao Q, Krogslund M , et al. Acupuncture on the day of embryo transfer significantly improves the reproductive outcome in infertile women: a prospective, randomized trial[J]. Fertil Steril, 2006,85(5):1341-1346
doi: 10.1016/j.fertnstert.2005.08.070
[5] Dieterle S, Ying G, Hatzmann W , et al. Effect of acupuncture on the outcome of in vitro fertilization and intracytoplasmic sperm injection: a randomized, prospective, controlled clinical study[J]. Fertil Steril, 2006,85(5):1347-1351
doi: 10.1016/j.fertnstert.2005.09.062
[6] Khorram NM, Horton S, Sahakian V . The effect of acupuncture on the outcome of in vitro fertilization[J]. Fertil Steril, 2005,84(Suppl 1):S364
doi: 10.1016/j.fertnstert.2005.07.954
[7] Cui W, Sun W, Liu LL , et al. Study of the effect of electro-acupuncture treatment on the patients undergoing in-vitro-fertilization and embryo transfer[J]. Zhongguo Fu You Bao Jian, 2007,22(24):3403-3405
doi: 10.3969/j.issn.1001-4411.2007.24.038
崔薇, 孙伟, 刘莉莉 , 等. 电针干预对体外受精-胚胎移植患者的作用研究[J]. 中国妇幼保健, 2007,22(24):3403-3405
doi: 10.3969/j.issn.1001-4411.2007.24.038
[8] Benson MR, Elkind-Hirsch KE, Theall A , et al. Impact of acupuncture before and after embryo transfer on the outcome of in vitro fertilization cycles: A prospective single blind randomized study[J]. Fertil Steril, 2006,86(3 Suppl 1):S135
[9] Teshima DRK, Nunes C , Chedid-grieco S.The effect of acupuncture in assisted reproduction techniques[J]. Fertil Steril, 2007,88(Suppl 1):S329-S330
[10] Smith C, Coyley M, Norman RJ , et al. Influence of acupuncture stimulation on pregnancy rates for women undergoing embryo transfer[J]. Fertil Steril, 2006,85(5):1352-1358
doi: 10.1016/j.fertnstert.2005.12.015 pmid: 16600225
[11] Udoff LC, Zhang G, Patwardhan S , et al. The effect of acupuncture on outcomes in in-vitro fertilization(IVF)[J]. Fertil Steril, 2006,86(3 Suppl 1):S145
doi: 10.1016/j.fertnstert.2006.07.389
[12] Lehl K, Pitzer L, Stevens JM , et al. Elective acupuncture treatment pre and post embryo transfer: Comparison of clinical pregnancy and implantation rates within age groups and in recipients of donor oocyte[J]. Fertil Steril, 2006,86(3 Suppl 1):S340-S341
[13] Domar AD, Meshay I, Kelliher J , et al. The impact of acupuncture on in vitro fertilization outcome[J]. Fertil Steril, 2006,85(5):1359-1363
doi: 10.1016/j.fertnstert.2005.10.063 pmid: 16600220
[14] Stener-Victorin E, Waldenström U, Wikland M , et al.Electro-acupuncture as a peroperative analgesic method and its effects on implantation rate and neuropeptide Y concentrations in follicular fluid[J]. Hum Reprod, 2003,18(7):1454-1460
doi: 10.1093/humrep/deg277
[15] Wang WP, Jerome H, Jung K , et al. A matched controlled study to evaluate the efficacy of acupuncture for improving pregnancy rates following in vitro fertilization-embryo transfer[J]. Fertil Steril, 2005,83(5 Suppl 1):S24
[16] Craig LB, Criniti AR, Hansen KR , et al. Acupuncture lowers pregnancy rates when performed before and after embryo transfer[J]. Fertil Steril, 2007,88(Suppl 1):S40
doi: 10.1016/j.fertnstert.2007.07.143
[17] McDonough PG . Acupuncture and IVF controversies[J]. Fertil Steril, 2007,87(4):1000
[18] Stener-Victorin E, Waldenström U, Nilsson L , et al.A prospective randomized study of electro-acupuncture versus alfentanil as anaesthesia during oocyte aspiration in in-vitro fertilization[J]. Hum Reprod, 1999,14(10):2480-2484
doi: 10.1093/humrep/14.10.2480
[19] Magarelli PC, Cohen M, Cridennda DK . Proposed mechanism of action of acupuncture on IVF outcomes[J]. Fertil Steril, 2006,86(3 Suppl 1):S174-S175
doi: 10.1016/j.fertnstert.2006.07.464
[20] Dong JC . The clinical observation of follicular maldevelopment[J]. Zhongguo Zhong Yi Yao Xin Xi Za Zhi, 2007,14(9):68-69
doi: 10.3969/j.issn.1005-5304.2007.09.036
董纪翠 . 电针治疗卵泡发育不良临床观察[J]. 中国中医药信息杂志, 2007,14(9):68-69
doi: 10.3969/j.issn.1005-5304.2007.09.036
[21] Stener-Victorin E, Obayaski RK, Watanabe O , et al. Effects of electro-acupuncture stimulation of different frequencies and intensities on ovarian blood flow in anaesthetized rats with steroid-induced polycystic ovaries[J]. Repro Biol Endocinol, 2004,( 2):16
[22] Goswamy RK, Williamas G, Steptoe PC , et al. Decreased uterine perfusion–a cause of infertility[J]. Hum Reprod, 1988,3(8):955-959
doi: 10.1016/S0090-8258(88)80034-9 pmid: 3060479
[23] Gong X, Li Q, Zhang Q , et al. Predicting endometrium receptivity with parameters of spiral artery blood flow[J]. J Huazhong Univ Sci Technolog Med Sci, 2005,25(3):335-338
doi: 10.1007/BF02828160 pmid: 16201289
[24] Stener-Victorin E, Waldenström U, Andersson SA , et al.Reduction of blood flow impedance in the uterine arteries of infertile women with electro-acupuncture[J]. Hum Reprod, 1996,11(6):1314-1317
doi: 10.1093/oxfordjournals.humrep.a019378
[25] Zhang X, Chen CH, Cofino E , et al. Increased endometrial thickness is associated with improved treatment outcome for selected patients undergoing in-vitro fertilization-embryo transfer[J]. Fertil Steril, 2005,83(2):336-340
doi: 10.1016/j.fertnstert.2004.09.020
[26] Liu XY, Huang GY, Zhang MM . Effects of acupuncture promoting embryo implantation and development in the rat with dysfunctional embryo implantation[J]. Zhongguo Zhen Jiu, 2007,27(6):439-442
刘新玉, 黄光英, 张明敏 . 针刺对胚泡着床障碍大鼠胚泡着床及发育的影响[J]. 中国针灸, 2007,27(6):439-442
[27] Yu W, Horn B, Acacio B , et al. A pilot study evaluating the combination of acupuncture with sildenafil on endometrial thickness[J]. Fertil Steril, 2007,87(4 Suppl 2):439-442
doi: 10.1016/j.fertnstert.2006.06.053 pmid: 17094972
[28] Magarelli PC, Cridennda DK . Acupuncture & IVF poor responders: a cure?[J]. Fertil Steril, 2004,81(Suppl 3):S20
[29] Ayoubi JM, Epiney M, Brioschi PA , et al. Comparison of changes in uterine contraction frequency after ovulation in the menstrual cycle and in in vitro fertilization cycles[J]. Fertil Steril, 2003,79(5):1101-1105
doi: 10.1016/S0015-0282(03)00179-1
[30] Pak SC, Na CS, Kim JS , et al. The effect of acupuncture on uterine contraction induced by oxytocin[J]. Am J Chin Med, 2000,28(1):35-40
doi: 10.1142/S0192415X00000064 pmid: 10794115
[31] Kim JS, Shin KH, Na CS . Effect of acupuncture treatment on uterine motility and cyclooxygenase-2 expression in pregnant rats[J]. Gynecol Obstet Invest, 2000,50(4):225-230
doi: 10.1159/000010321
[32] Paulus WE, Zhang MM, Sterzik K , et al. Motility of the endometrium after acupuncture treatment[J]. Fertil Steril, 2003,80(Suppl 3):131
doi: 10.1016/S0015-0282(03)01222-6
[33] Liu JL, Chen SP, Gao YH . Effect of electroacu-puncture of different acupoints on myoelectrical activities of the uterus in rats[J]. Zhen Ci Yan Jiu, 2007,32(4):237-242
doi: 10.3969/j.issn.1000-0607.2007.04.005
刘俊岭, 陈淑萍, 高永辉 . 电针不同穴位对大鼠子宫平滑肌电活动的影响[J]. 针刺研究, 2007,32(4):237-242
doi: 10.3969/j.issn.1000-0607.2007.04.005
[34] Zhang MY, Li GG, Cai HD , et al. Sterility and reproductive endocrinology(2nd ed)[M]. Beijing: Peking University Medical Press, 2005,( 2nd ed):162-163
张明杨, 李国光, 蔡鸿德 , 等. 不孕症及生殖内分泌学(第2版)[M]. 北京: 北京大学医学出版社, 2005,( 第2版):162-163
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