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Journal of Chinese Integrative Medicine ›› 2009, Vol. 7 ›› Issue (8): 736-740.doi: 10.3736/jcim20090806

• Original Clinical Research • Previous Articles     Next Articles

Effects of oxymatrine on microinflammatory state in patients undergoing continuous hemodialysis: A randomized controlled trial

 Wen-xiang Zhou,Wen-bin Zheng, Xiao-mei Huang, Ying Zhang, Xiang-zhi Nie, Hong-bing Li, Da He, Lan-qian Xie   

  1. Department of Nephrology, Wuhan No. 1 Hospital, Wuhan 430022, Hubei Province, China
  • Received:2009-02-27 Accepted:2009-06-03 Online:2009-08-20 Published:2009-08-15
  • Contact: Wen-xiang Zhou E-mail:wenxiangzhou@hotmail.com

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Background

Chronic microinflammatory state is common in the patients undergoing maintenance hemodialysis (MHD), which seriously affects the long-term survival rate of MHD patients. It is important to improve the microinflammatory state in MHD patients.
Objective

To investigate the effects of oxymatrine on microinflammatory state in patients undergoing continuous hemodialysis.Design, setting, participants and interventions: Sixty MHD patients in Blood Purification Center, Wuhan No.1 Hospital, from June to September 2008, were randomized into treatment group (30 cases) and control group (30 cases). Oxymatrine Capsule was orally administered to the patients in the treatment group 0.4 g once a day for 3 months, while the patients in the control group were not given oxymatrine. Main outcome measures: The serum concentrations of high-sensitivity C-reactive protein (hs-CRP), interleukin-1β(IL-1β), tumor necrosis factor-α (TNF-α), albumin (Alb), pre-albumin (PAB), total cholesterol (TC) and triglyceride (TG) were detected before and after 3-month treatment.
Results

Three patients in the treatment group had a stomachache on the first day of treatment, and two out of the three quitted the trial. The stomachache disappeared in one patient after stopping taking the drug, and did not recur after continuing to receive the intervention. Two patients in the treatment group had skin rash with pruritus on the second day of treatment. The rash disappeared after the patients stopped taking the drug, and did not recur after continuing to receive the intervention. A total of 58 cases accessed to the statistical analysis, while 2 cases were excluded. In the treatment group, the concentrations of hs-CRP, IL-1β and TNF-α significantly decreased (P<0.01) and the mean values of Alb, PAB, TC and TG significantly increased after the treatment as compared with those before the treatment (P<0.01), but there were no significant differences in all parameters between before and after treatment in the control group. There were significant differences in all parameters between the treatment group and the control group after treatment (P<0.01, P<0.05).
Conclusion

Oxymatrine can improve the microinflammatory state in the patients undergoing continuous hemodialysis.

Key words: Oxymatrine, Hemodialysis, Inflammation, Randomized controlled trial

Figure 1

Flow diagram of this randomized trial "

Table 1

General data in two groups"

Item Control group (n=30) Treatment group (n=28)
Age ($\bar{x}$±s, years) 44.27±16.19 48.06±12.47
Sex (male/female) 17/13 15/13
Duration of hemodialysis ($\bar{x}$±s, months) 53.4±14.9 56.7±21.8
Primary disease
Chronic glomerulonephritis 21 19
Diabetic nephropathy 4 3
Hypertension 3 4
Polycystic kidney disease 0 1
Unknown 2 1

Table 2

Changes of biochemical parameters in two groups ($\bar{x}$±s)"

Group n Alb (g/L) PAB (g/L) TC (mmol/L) TG (mmol/L)
Control
Before treatment 30 37.13±2.41 0.29±0.04 3.89±0.61 1.46±0.36
After treatment 30 37.95±1.64 0.28±0.05 3.99±0.61 1.48±0.48
Treatment
Before treatment 28 37.51±2.21 0.29±0.05 3.72±0.46 1.44±0.34
After treatment 28 41.29±1.91**△△ 0.33±0.05**△△ 4.19±0.52**△ 1.73±0.23**△△

Table 3

Changes of microinflammation indexes in two groups ($\bar{x}$±s)"

Group n hs-CRP (mg/L) IL-1β (pg/L) TNF-α (pg/L)
Control
Before treatment 30 10.56±1.49 33.41±2.83 24.37±1.96
After treatment 30 10.78±1.02 33.95±2.00 24.20±1.59
Treatment
Before treatment 28 10.27±1.55 33.97±2.30 26.16±1.90
After treatment 28 7.38±1.36**△△ 22.48±1.94**△△ 19.29±1.50**△
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